 | Ben Schwartz als Leo / Janitor Man (voice) |
 | Omar Benson Miller als Raph / Office Man 1 (voice) |
 | Brandon Mychal Smith als Mikey / Foot Soldier 1 (voice) |
 | Josh Brener als Donnie / Security AI / Tank AI / Dragged Man (voice) |
 | Haley Joel Osment als Casey Jones / Foot Soldier 3 (voice) |
 | Eric Bauza als Splinter / Additional Characters (voice) |
 | Kat Graham als April O'Neil / Café Woman 3 (voice) |
 | Jim Pirri als Krang One / Military Soldier 1 (voice) |
 | Toks Olagundoye als Krang Two / Military Woman (voice) |
 | Rhys Darby als Hypno-Potamus (voice) |
 | Rob Paulsen als Various Characters (voice) |
 | John Michael Higgins als Warren Stone (voice) |
 | Eugene Byrd als Security Guard / Police / Office Man 2 / Café Man (voice) |
 | Meghan Falcone als Office Woman 1 / Office Woman 2 (voice) |
 | Nika Futterman als Various Characters (voice) |
 | Oliver Vaquer als Various Characters (voice) |
| Andy Suriano | Director |
| Matthew Feinman | Editor |
| Brent Crowe | Production Manager |
| Hunter Hill | Production Assistant |
| David Feiss | Storyboard Artist |
| Matthew Humphreys | Storyboard Artist |
| Lyndon Ruddy | Storyboard Artist |
| India Swift | Storyboard Artist |
| Joshua Hoskison | Script Coordinator |
| Terri Douglas | ADR Voice Casting |
| Greg Crawford | ADR Mixer |
| Jessey Drake | Sound Effects Editor |
| Michael Wessner | Dialogue Editor |
| Babak Arjmand | Animation |
| Cal Luo | Special Effects |
| Thomas Barkel | Animation Director |
| Hayden Browne | Animation |
| Charlie Cai | Animation |
| Clarita Cailan | Animation |
| Darryl Chen | Animation |
| Adriana Duran | Animation |
| Aline Garcia | Animation |
| Rose Hammer | Key Animation |
| Juvensia | Key Animation |
| Craig Kellman | Character Designer |
| Jeremy Le | Animation |
| Jazmine Lee | Background Designer |
| Joanne Lee-Jung | Animation |
| Linden Li | Background Designer |
| Nikita Chan | Background Designer |
| Hardik Manktala | Animation |
| Victoria Mazzei | Character Designer |
| Paige McIntosh | Character Designer |
| Chris Palamara | Character Designer |
| Tomasz Pilarski | Animation |
| Samuel Read | Character Designer |
| Cheeks Chico Requieron | Key Animation |
| Therese Reyes | Animation |
| Julia Schoel | Animation |
| Isabella Spagnolo | Key Animation |
| Christoper Tan | Character Designer |
| Eric Terlato | Animation |
| Chelsea Thompson | Animation |
| Anastasia Turaeva | Animation |
| Susanna Wang | Key Animation |
| Ant Ward | Executive Producer |
| Vladimir Radev | Line Producer |
| Andy Suriano | Story |
| Ant Ward | Story |
| Billy Weber | Editor |
| Ant Ward | Director |
| Andy Suriano | Executive Producer |
| Tony Gama-Lobo | Screenplay |
| Rebecca May | Screenplay |
| Matt Mahaffey | Original Music Composer |
| JJ Conway | Head of Story |
| Kevin Molina-Ortiz | Head of Story |
| Andy Suriano | Production Design |
| Carl Beu | Art Direction |
| Andrea Hennen | Casting |
| Gene Vassilaros | Original Casting |
| Shiondre Austin | Original Casting |
| Gladyfaith Abcede | Story Artist |
| Madeleine Flores | Story Artist |
| Laura Gille | Story Artist |
| Peter Laird | Characters |
| Kevin Eastman | Characters |
| Tanya Melendez | Associate Producer |
