 | Tom Hanks als Michael Sullivan |
 | Tyler Hoechlin als Michael Sullivan, Jr. |
 | Paul Newman als John Rooney |
 | Jude Law als Harlen Maguire |
 | Daniel Craig als Connor Rooney |
 | Stanley Tucci als Frank Nitti |
 | Jennifer Jason Leigh als Annie Sullivan |
 | Liam Aiken als Peter Sullivan |
 | Dylan Baker als Alexander Rance |
 | Ciarán Hinds als Finn McGovern |
 | David Darlow als Jack Kelly |
 | Kevin Chamberlin als Frank the Bouncer |
 | Doug Spinuzza als Calvino |
 | Kurt Naebig als Tenement Murderer |
 | Duane Sharp als Father Callaway |
| Michael Sassone als Motel Manager |
| Roderick Peeples als Nitti's Henchman |
 | Keith Kupferer als Nitti's Henchman |
| Lara Phillips als Ruby the Waitress |
 | Mina Badie als Betty the Waitress |
| Heidi Jayne Netzley als Prostitute |
| Lance Baker als Crime Scene Policeman |
| Nicolas Cade als Boy Michael Fights |
 | John Judd als Rooney's Business Associate |
 | Kerry Rossall als Rooney's Henchman |
 | Ian Barford als Rooney's Henchman |
 | Rob Maxey als Drug Store Owner |
 | Maureen Gallagher als Michael's Teacher |
 | Diane Dorsey als Aunt Sarah |
 | Harry Groener als Mr. McDougal |
 | Peggy Roeder als Farmer Virginia |
 | James Greene als Farmer Bill |
 | Anthony LaPaglia als Al Capone (uncredited) |
 | Paul Turner als Finn McGovern's Henchman |
| Craig Spidle als Rooney's Henchman |
| Sam Mendes | Director |
| Conrad L. Hall | Director of Photography |
| Jill Bilcock | Editor |
| David Self | Screenplay |
| Thomas Newman | Original Music Composer |
| Debra Zane | Casting |
| Dennis Gassner | Production Design |
| Nancy Haigh | Set Decoration |
| Albert Wolsky | Costume Design |
| Richard L. Johnson | Art Direction |
| Frank P. Calzavara | Stunts |
| Tara B. Cook | Associate Producer |
| Joan Bradshaw | Executive Producer |
| Cherylanne Martin | Associate Producer |
| Walter F. Parkes | Executive Producer |
| Dean Zanuck | Producer |
| Richard D. Zanuck | Producer |
| Sam Mendes | Producer |
| Amanda Brand | Unit Publicist |
| Joey Box | Utility Stunts |
| Ted Haigh | Assistant Art Director |
| Jann K. Engel | Assistant Art Director |
| Paul Howarth | Visual Effects Editor |
| Michael L. Fink | Visual Effects Supervisor |
| Terri Taylor | Casting Associate |
| Marcy Grace Froehlich | Assistant Costume Designer |
| Thomas Minton | Assistant Art Director |
| Paul Clemente | Visual Effects Producer |
| Chris Cummings | Art Department Coordinator |
| Heather Pollock | Set Costumer |
| Robert Q. Mathews | Costume Supervisor |
| Kathryn Blondell | Hairstylist |
| Dan Schalk | First Assistant Editor |
| Bill Bernstein | Music Editor |
| Patrick Caulfield | Set Costumer |
| Thomas Pasatieri | Orchestrator |
| Harrison McEldowney | Choreographer |
| Mark Howard | Choreographer |
| Celia Haining | First Assistant Editor |
| Daniel C. Striepeke | Makeup Artist |
| Susan Kowarsh | Assistant Costume Designer |
| Phillip Ellman | Greensman |
| Clyde E. Bryan | First Assistant Camera |
| Brian Lunt | Projection |
| Robert Neilson | Transportation Coordinator |
| Anthony Joseph Fatigato | Painter |
| Carrie Goodman | Location Scout |
| Kerry Sanders | Set Designer |
| Michael Clossin | Stand In |
| James Hogan | Transportation Captain |
| Henry Schaub | Standby Painter |
| François Duhamel | Still Photographer |
| Jane Blank | Seamstress |
| Doug Coleman | Stunt Coordinator |
| Kathryn Madden | Craft Service |
| William Patterson | Art Department Assistant |
| James M. Davis | Construction Foreman |
| Todd Homme | Executive Music Producer |
| Erica Frauman | Post Production Supervisor |
| Joseph Paoletti | Transportation Co-Captain |
| John J. Slove Jr. | Propmaker |
| Bud Belyeu | Picture Car Coordinator |
| Daniel B. Clancy | Leadman |
| P. Scott Sakamoto | Camera Operator |
| Carla Meyer | Dialect Coach |
| George Hartmann | Driver |
| Jim Turner | Production Controller |
| Heather Sharpe | Production Office Assistant |
| Jeff Passanante | Construction Coordinator |
| Jill S. Litwin | Set Production Assistant |
| Michael J. Malone | Unit Production Manager |
| Allen Hall | Special Effects Coordinator |
| Aaron Richmond | Editorial Production Assistant |
| Scott A. Hecker | Sound Editor |
| Chris Glomp | Best Boy Electric |
| James F. Roorda | Rigging Grip |
| Bill Banyai | Sound Engineer |
| Kathryn Mindala | Production Accountant |
| Phil Hetos | Color Timer |
| Scott A. Hecker | Supervising Sound Editor |
| Stephen Andrzejewski | Location Manager |
| Thomas Vicari | Scoring Mixer |
| Cortland Boyd | Electrician |
| David M. Roberts | Boom Operator |
| John Pritchett | Production Sound Mixer |
| Rick Thomas | Gaffer |
| Vince Cordero | Rigging Gaffer |
| Dhana Gilbert | Production Coordinator |
| Jason W. Jennings | Sound Effects Editor |
| Bob Beemer | Sound Re-Recording Mixer |
| Jeffrey Edward Baksinski | 3D Supervisor |
| Matthew Haskins | Camera Loader |
| Mark Pappas | Foley Editor |
| Tom Stern | Chief Lighting Technician |
| Kelly R. Borisy | Key Grip |
| Paige Augustine | Set Dresser |
| Christopher Glasgow | Grip |
| Joe Dorn | Supervising ADR Editor |
| Benjamin Nowicki | Set Decorating Coordinator |
| Mike Schwake | Dolly Grip |
| Pamela Lynn Thomas | Casting Assistant |
| Chris Tedesco | Musician |
| Guillaume DeLouche | Assistant Property Master |
| Barbara Harris | ADR Voice Casting |
| Gabriela Ríos | Assistant Production Coordinator |
| Mickie Paskal | Casting Consultant |
| Jennifer Jobst | Key Costumer |
| K.C. Hodenfield | First Assistant Director |
| Jeff Okabayashi | Second Assistant Director |
| Gary Burritt | Negative Cutter |
| Carmen Flores De Tanis | Assistant Sound Editor |
| Conrad L. Hall | In Memory Of |
| Harry Lu | Armorer |
| Benjamin Beardwood | Dialogue Editor |
| Doug Harlocker | Property Master |
| Gary Lewis | Dialogue Editor |
| James D'Damery Jr. | Second Assistant Accountant |
| Larry McCaffrey | Technical Advisor |
| Howard London | ADR Mixer |
| Ross Dunkerley | Assistant Chief Lighting Technician |
| Judith Bouley | Additional Casting |
| George Budd | Music Consultant |
| Jamie Biehl | Extras Casting Assistant |
| Matthew Dettmann | Foley Artist |
| Martin L. Hudson | Assistant Location Manager |
| Aimee Lippert | Assistant Makeup Artist |
| Steve Battaglia | Second Second Assistant Director |
| Sven E. Fahlgren | Post Production Coordinator |
| Gerald A. King | Key Rigging Grip |
| Steven R. Molen | Production Executive |
| Kurt Greufe | First Assistant Accountant |
| Tiffany Smith | Visual Effects Production Manager |
| Kim Kahana Jr. | Stunt Double |
| Fred Folmer | Best Boy Grip |
| Renee D. Czarapata | Payroll Accountant |
| Michael Bender | Production Secretary |
| Lane Burch | Foley Mixer |
| Chris Buzek | Assistant Camera |
| Lea Morement | Assistant Editor |
| Gretchen Gain | Costumer |
| Kelly Diehl | Libra Head Technician |
| Melanie Cassidy | Location Assistant |
| Suzanne Trucks | Second Assistant Camera |
| Doug Coleman | Second Unit Director |
| Tom Gagnon | Swing |
| Thomas Kittle | Special Effects Technician |
| Dennis Hoffman | Head of Production |
| Krystine Lankenau | Rotoscoping Artist |
| Kyoko Kageyama | Travel Coordinator |
| Chris Castaldi | Production Assistant |
| Scott Millan | Sound Re-Recording Mixer |
| Richard Piers Rayner | Graphic Novel |
| Max Allan Collins | Graphic Novel |
