 | Matthew McConaughey als Dirk Pitt |
 | Penélope Cruz als Eva Rojas |
 | Steve Zahn als Al Giordino |
 | William H. Macy als Admiral Jim Sandecker |
 | Lennie James als General Zateb Kazim |
 | Lambert Wilson als Yves Massarde |
 | Glynn Turman als Dr. Frank Hopper |
 | Rainn Wilson als Rudi Gunn |
 | Clint Dyer als Oshodi |
 | Delroy Lindo als Carl |
 | Robert Cavanah als Captain Tombs |
 | Jude Akuwudike als Imam |
 | Mark Aspinall als Lawyer |
 | Rakie Ayola als Mrs. Nwokolo |
| Christopher Bello als Train Driver |
 | Patrick Malahide als Ambassador Polidori |
 | Nicholas Beveney als Gunboat 1 Officer |
| Empotoe Bosage als Pick Up Truck Guard |
| Matthew Flynn als 1st Lieutenant, Ironclad |
| Paulin Fodouop als Modibo |
| Ouahbou Houcine als Tuareg Village Boy #1 |
 | Emmanuel Ighodaro als Kazim's Officer Asselar |
 | Maurice Lee als Zakara |
 | Daniel Njo Lobé als Tuareg Sangare |
 | Francis Magee als Fuse Cutter |
| Thierno Amath Mbaye als Pick Up Truck Driver |
 | Femi Ogunbanjo als Modibo's Tuareg #2 |
 | Eddie Osei als Train Guard |
| Nathan Osgood als Gun Captain |
| Lahcen Ouezgane als Tuareg Village Boy #2 |
 | Robert Paterson als NUMA Crew Member |
 | Abdul Salis als Oumar |
| Tosin Sanyalo als Azikiwe Nwokolo |
 | Christopher Saul als Pilot, Ironclad |
| Billy Seymour als Powder Monkey |
 | Mark Springer als Solar Plant Guard |
| Celestine Vita als Old Woman in Labbezanga |
| Mark Wells als Sailor Who Drops Gold |
| Anna Pinnock | Set Decoration |
| Seamus McGarvey | Director of Photography |
| Stephanie Austin | Producer |
| Mace Neufeld | Producer |
| William H. Brown | Co-Producer |
| Anna B. Sheppard | Costume Design |
| Clint Mansell | Original Music Composer |
| James V. Hart | Screenplay |
| Matthew McConaughey | Executive Producer |
| Allan Cameron | Production Design |
| Tony Reading | Art Direction |
| Giles Masters | Art Direction |
| Anne McCarthy | Casting |
| Adam Aldridge | Special Effects Technician |
| Henning Molfenter | Co-Producer |
| Jean Bourne | Script Supervisor |
| David Barron | Co-Producer |
| Nina Gold | Casting |
| Mark Auguste | Sound Effects Editor |
| Thierry Potok | Co-Producer |
| Leslie Shatz | Sound Designer |
| Neill Gorton | Prosthetic Designer |
| Breck Eisner | Director |
| Clive Cussler | Novel |
| Thomas Dean Donnelly | Screenplay |
| John C. Richards | Screenplay |
| Howard Baldwin | Producer |
| Karen Elise Baldwin | Producer |
| Andrew MacRitchie | Editor |
| E. J. Foerster | Second Unit Director |
| Peter Gleaves | ADR Mixer |
| Nicholas Dodd | Orchestrator |
| Nicholas Dodd | Conductor |
| Lee Sheward | Stunt Coordinator |
| William J. Immerman | Executive Producer |
| Nick Morton | Co-Producer |
| Chris Munro | Sound Mixer |
| Chris Thompson | Line Producer |
| Mike Phillips | Co-Producer |
| Mark Albela | Co-Producer |
| Denise O'Dell | Co-Producer |
| Ben Pugh | Production Assistant |
| Susan Luciani | Camera Trainee |
| Lis Kern | Associate Producer |
| Scott Thaler | Production Manager |
| Scott Thaler | Line Producer |
| Andrew Reif | Associate Producer |
| Gus Gustawes | Executive Producer |
| Dan Frye | Propmaker |
| Christopher Newman | First Assistant Director |
| Marc Homes | Assistant Art Director |
| James Seddon | Dolby Consultant |
| Steve Griffin | Stunts |
| Adam Inglis | Colorist |
| Mara Bryan | Visual Effects Supervisor |
| Carmila Gittens | Special Effects Coordinator |
| Felicity Cottrell | Foley Artist |
| John Marzano | Aerial Director of Photography |
| Paul Apted | First Assistant Sound Editor |
| Tom Harrison-Read | First Assistant Editor |
| Anna Skrein | Art Department Coordinator |
| Whitney James | Makeup Artist |
| Marcus Alexander | Digital Intermediate Producer |
| Sylvia Steinbrecht | Assistant Set Dresser |
| Sze-Wun Li | Apprentice Sound Editor |
| Tim Keene | Visual Effects Producer |
| Keith Hamshere | Still Photographer |
| Dina Eaton | Music Editor |
| Neil Miller | Matte Painter |
| John Cormican | Prosthetic Makeup Artist |
| Lee Walters | Gaffer |
| Daryl Bristow | Wardrobe Supervisor |
| Nigel Mills | Supervising Sound Editor |
| Steve Brooke Smith | Assistant Camera |
| Cristina Sopeña | Costume Supervisor |
| Charles Howell | Visual Effects Coordinator |
| Karen Dawson | Makeup Artist |
| Karen Dawson | Hairstylist |
| Martin Samuel | Hairstylist |
| Susan d'Arcy | Unit Publicist |
| Vicki Dee Rock | Executive Producer |
| Jane Clive | Assistant Costume Designer |
| David Manzanares | Location Scout |
| Kathy Ducker | Hair Assistant |
| Conor Coughlan | Pyrotechnician |
| John Nixon | Armorer |
| Guiomar Alonso | Stunt Double |
| Dominic Tuohy | Special Effects Supervisor |
| Paul Couch | Standby Painter |
| Aileen Seaton | Hair Designer |
| Marc Wolff | Aerial Coordinator |
| Brendan Gunn | Dialect Coach |
| Ben Howarth | Second Assistant Director |
| Joshua Oppenheimer | Screenplay |
| Stuart Clarke | Scenic Artist |
| Alexander Beddow | ADR Recordist |
| Vanessa Baker | ADR Voice Casting |
| Kathy Hughes | Additional Script Supervisor |
| Philip Alton | Dialogue Editor |
| Philip Alton | ADR Editor |
| Antonio Bloch | Sound Recordist |
| Lindsay Fellows | Music Supervisor |
| Sophie Drouin | Production Accountant |
| Matt Curtis | Title Designer |
| Temple Clark | Storyboard Artist |
| Usha Chaman | Assistant Production Coordinator |
| David Raines | Additional Sound Re-Recording Mixer |
| Stephen Challenor | Supervising Carpenter |
| Gary Hutchings | Key Grip |
| Gavin Buckley | Visual Effects Editor |
| Saskia Green | Art Department Assistant |
| Bradley Woodbridge | Painter |
| Bruce Gordon | Sculptor |
| Nigel Permane | First Assistant Camera |
| David Holliday | Grip |
| Charif Lemhemdi | Cableman |
| Stephen McGregor | Carpenter |
| David Adamthwaite | Driver |
| Stephen Evans | Clapper Loader |
| Jan Meade | Projection |
| Karim Khakahni | Set Production Assistant |
| Gary Webber | Stand In |
| David Hyde | Technical Supervisor |
| Hafid Balafrej | Unit Production Manager |
| Peter Chester | Best Boy Electric |
| Andy Bell | Electrician |
| Gavin Walters | Rigging Gaffer |
| Bill Barringer | Location Manager |
| Katryna Samut-Tagliaferro | Production Coordinator |
| Paul Munro | Boom Operator |
| James Benson | 3D Artist |
| Richard Briscoe | Digital Compositors |
| Tarik Ait Ben Ali | Additional Second Assistant Director |
| Diane Conn | Executive Assistant |
| Mark Wright | Negative Cutter |
| Silvana Sacco | Costume Illustrator |
| Tim Battersby | Focus Puller |
| Rodrigo López | Second Assistant Camera |
| Lahcen Abbana | Costume Assistant |
| Mustapha Adidou | Assistant Location Manager |
| Luis Casacuberta | Second Second Assistant Director |
| Kristine Bochum | Second Assistant Accountant |
| Jack Dyer | Construction Buyer |
| Marta Ortega Gonzalez | Costume Mistress |
| Patricia Aguirre | Dresser |
| Tom Glaisyer | Third Assistant Director |
| Stephen Conway | Dressing Prop |
| Toby Glover | Graphic Designer |
| Scott MacIntyre | Special Props |
| Tony Gil | Best Boy Grip |
| Bacha | Casting Assistant |
| Gary Lane | Wardrobe Assistant |
| Peter Hornbuckle | Wardrobe Master |
| Jack James | Online Editor |
| Christopher Russell | Post Production Coordinator |
| Elabdi Abdelhadi | Location Assistant |
| Naima Alaoui | Location Coordinator |
| Ahmed Achouba | Assistant Accountant |
| Larry Knox | Generator Operator |
| Michael Conran | Health and Safety |
| John McHale | Pilot |
| Jan Hogevold | Production Executive |
| Ahmed Hajji | Production Runner |
| Mercedes Barbod | Production Secretary |
