 | Steve Zahn als Wayne Lefessier |
 | Jack Black als J.D. McNugent |
 | Jason Biggs als Darren Silverman |
 | Amanda Peet als Judith Fessbeggler |
 | Amanda Detmer als Sandy |
 | R. Lee Ermey als Coach |
 | Neil Diamond als Self |
 | Kyle Gass als Bar Dude |
 | Andrew McIlroy als Waiter |
 | Norman Armour als Minister |
 | Colin Foo als Old Man |
 | Christopher Logan als Vageet |
| Esme Lambert als Raccoon Woman |
| Max Fomitchev als Mime |
| Tony Parsons als Newscaster |
 | Oscar Goncalves als Man |
 | Lillian Carlson als Mother Superior |
 | Mark Aaron Wagner als Luigi |
 | Stephen Chang als Thai Referee |
 | Eliza Norbury als Wayne's Mom |
 | Michael Roberds als Doctor |
 | Sean Owen Roberts als Wong |
 | Ken Camroux-Taylor als Warren |
 | Lowela Jotie als Cheerleader |
 | Odessa Munroe als Hooker |
 | Tracy Trueman als Hooker |
 | Devin Douglas Drewitz als Young Wayne |
| Carly McKillip als Cute Girl |
 | Carla Boudreau als Beautiful Woman |
 | Biski Gugushe als Cop At Darren's House |
 | Steven McMichael als Josh |
 | Dennis Dugan als Referee |
 | Larry Lam als Thai Kickboxer |
 | Brett Armstrong als Brett |
| Hank Nelken | Screenplay |
| Dennis Dugan | Director |
| Arthur Albert | Director of Photography |
| Greg DePaul | Screenplay |
| Patrick J. Don Vito | Editor |
| J.J. Makaro | Stunt Coordinator |
| Mary Vernieu | Casting |
| Anne McCarthy | Casting |
| Felicia Fasano | Casting |
| Melissa Toth | Costume Design |
| Michelle Kuznetsky Silverman | Music Supervisor |
| Mary Ramos | Music Supervisor |
| Warren Carr | Unit Production Manager |
| Daniel Silverberg | First Assistant Director |
| Kathy Houghton | Second Assistant Director |
| James Steuart | Art Direction |
| Neal H. Moritz | Producer |
| Bruce Berman | Executive Producer |
| Bernie Goldmann | Executive Producer |
| Brad Luff | Executive Producer |
| Peter Ziegler | Executive Producer |
| Michael S. Bolton | Production Design |
| Debra Neil-Fisher | Editor |
| Warren Carr | Co-Producer |
| Louise Roper | Set Decoration |
| Thom Ryan | First Assistant Camera |
| Justin Bergler | Second Assistant Camera |
| Jeff Upton | Chief Lighting Technician |
| Lisa Taylor Roberts | Key Makeup Artist |
| Andrew Mulkani | Key Grip |
| Tony Poulsen | Boom Operator |
| Tony Lazarowich | Special Effects Coordinator |
| Bill McMahon | Set Designer |
| R.D. 'Luther' Fairbairn | Property Master |
| Lee Anne Muldoon | Unit Publicist |
| Joseph Lederer | Still Photographer |
| Steve Eathorne | Third Assistant Director |
| Kevin O'Connell | Sound Re-Recording Mixer |
| Greg P. Russell | Sound Re-Recording Mixer |
| George H. Anderson | Supervising Sound Editor |
| Susan Dawes | Dialogue Editor |
| Suhail Kafity | Sound Effects Editor |
| Kelly Oxford | ADR Supervisor |
| Cindy Marty | Foley Supervisor |
| Ted Caplan | Foley Editor |
| Gary A. Hecker | Foley Artist |
| Matthew Dettmann | Foley Artist |
| Lane Burch | Foley Mixer |
| Howard London | ADR Mixer |
| Terry Hager | Color Timer |
| Mo Henry | Negative Cutter |
| Donna Bis | Key Hair Stylist |
| Michael Simpson | Music |
| Melissa R. Stubbs | Stunts |
| Ruby J. Munro | Script Supervisor |
| Marny Eng | Stunts |
| Rick Pearce | Stunts |
| Noby Arden | Stunts |
