 | Tobin Bell als John Kramer / Jigsaw |
 | Shawnee Smith als Amanda Young |
 | Angus Macfadyen als Jeff Reinhart |
 | Bahar Soomekh als Lynn Denlon |
 | Donnie Wahlberg als Eric Matthews |
 | Dina Meyer als Kerry |
 | Leigh Whannell als Adam Stanheight |
 | Mpho Koaho als Tim |
 | Barry Flatman als Judge Halden |
 | Lyriq Bent als Rigg |
 | J. LaRose als Troy |
 | Debra McCabe als Danica |
 | Costas Mandylor als Mark Hoffman |
 | Betsy Russell als Jill Tuck |
 | Jane Luk als Nurse - Emergency Room |
 | Stefan Georgiou als Dylan |
 | Niamh Wilson als Corbett Denlon |
 | Alan van Sprang als Chris |
 | Kim Roberts als Deborah |
 | Brian Paul als Doctor #1 |
| Zoe Heath als Female Forensic |
 | Billy Parrott als Male Nurse |
 | Dylan Trowbridge als Paramedic |
 | Franky G als Xavier - Dead |
 | Kelly Jones als SWAT Member Pete |
 | Vincent Rother als SWAT Member Joe |
| Nicholas Kaegi als Young Boy |
| Mark Poyser als Gun Shot Victim |
 | Timothy Burd als Obi |
| Dan Sudek als Aftermath Cop |
| Bill Vibert als Cop |
| Sandy Kellerman als Additional Voice Talent (voice) |
| Shauna Black als Additional Voice Talent (voice) |
 | Sean Sullivan als Additional Voice Talent (voice) |
| Larry Yachimec als Additional Voice Talent (voice) |
 | Darrell Dennis als Additional Voice Talent (voice) |
 | Christopher Marren als Additional Voice Talent (voice) |
 | Mike Butters als Paul (archive footage) (uncredited) |
| Paul Gutrecht als Mark (archive footage) (uncredited) |
| Darren Lynn Bousman | Director |
| Leigh Whannell | Screenplay |
| Mark Burg | Producer |
| Oren Koules | Producer |
| Charlie Clouser | Original Music Composer |
| David A. Armstrong | Director of Photography |
| Kevin Greutert | Editor |
| Stephanie Gorin | Casting |
| David Hackl | Production Design |
| Alex Kavanagh | Costume Design |
| Anthony Ianni | Art Direction |
| Liesl Deslauriers | Set Decoration |
| Stephanie Ingram | Key Hair Stylist |
| Sarah Fairbairn | Key Makeup Artist |
| François Dagenais | Prosthetic Makeup Artist |
| Elizabeth Scherberger | First Assistant Director |
| Yolanda Graci | First Assistant Director |
| Ron Lightfoot | Construction Coordinator |
| John Couto | Best Boy Electrician |
| Brian Gedge | Camera Operator |
| David Perkins | Camera Operator |
| Craig Stewart | Dolly Grip |
| Paul Dias | Electrician |
| Robert Dias | Electrician |
| Ramesh Yogendran | Gaffer |
| Ira Cohen | Gaffer |
| Christopher J. Toudy | Key Grip |
| Yuri Sandler | Key Grip |
| Steve Wilkie | Still Photographer |
| Stephanie Lees | Assistant Costume Designer |
| Les Handrahan | Costume Coordinator |
| Nick Iannelli | Digital Intermediate |
| Chris Wallace | Digital Intermediate |
| John Stubbings | Techno Crane Operator |
| Motassem Younes | Digital Intermediate |
| Diane Brunjes | First Assistant Editor |
| Paul Intson | Music Editor |
| Jonathan McHugh | Music Supervisor |
| Jonathan Scott Miller | Music Supervisor |
| Jonathan Platt | Music Supervisor |
| Lisa Burling | Script Supervisor |
| Tim Good | Special Effects Coordinator |
| Peter Denomme | Visual Effects Producer |
| Jon Campfens | Visual Effects Supervisor |
| Jason Hopfner | Boom Operator |
| Allan Fung | Dialogue Editor |
| John Laing | Dialogue Editor |
| Steve Baine | Foley |
| Tom Bjelic | Sound Effects Editor |
| Keith Elliott | Sound Re-Recording Mixer |
| Andrew Tay | Sound Re-Recording Mixer |
| Mark Zsifkovits | Sound Re-Recording Mixer |
| Mark Gingras | Supervising Sound Editor |
| John Douglas Smith | Supervising Sound Editor |
| Greg Copeland | Co-Producer |
| Greg Copeland | Production Manager |
| Peter Block | Executive Producer |
| James Wan | Story |
| Leigh Whannell | Story |
| Gregg Hoffman | Producer |
| Daniel J. Heffner | Executive Producer |
| James Wan | Executive Producer |
| Stacey Testro | Executive Producer |
| Leigh Whannell | Executive Producer |
| Troy Begnaud | Associate Producer |
| Jason Constantine | Executive Producer |
| Leigh Whannell | Original Film Writer |
| James Wan | Original Film Writer |
| Alison Reid | Stunt Coordinator |
| David Hackl | Second Unit Director |
| C.J. Lusby | Stunt Double |
| Bryan Renfro | Stunt Double |
| Cotton Mather | Stunt Double |
| Alison Reid | Stunt Double |
