 | Anna Faris als Cindy |
 | Regina Hall als Brenda |
 | Craig Bierko als Tom Ryan |
 | Bill Pullman als Henry Hale |
 | Anthony Anderson als Mahalik |
 | Leslie Nielsen als President Baxter Harris |
 | Molly Shannon als Marilyn |
 | Michael Madsen als Oliver |
 | Chris Elliott als Ezekiel |
 | Carmen Electra als Holly |
 | Shaquille O'Neal als Shaq |
 | Phil McGraw als Himself |
 | Cloris Leachman als Mrs. Norris |
 | Conchita Campbell als Rachel |
 | Beau Mirchoff als Robbie Ryan |
 | Kevin Hart als CJ |
 | DeRay Davis als Marvin |
 | Simon Rex als George |
 | YoungBloodZ als YoungBloodZ |
 | Bryan Callen als Harper |
 | Alonzo Bodden als Jamison |
 | Dave Attell als Knifeman |
 | Holly Madison als Blonde #1 |
 | Bridget Marquardt als Blonde #2 |
 | Kendra Wilkinson als Blonde #3 |
 | Drew Mikuska als Cody |
 | Chingy als Chingy |
| Fabolous als Gunman |
 | Lil' Jon als Gloating Driver |
 | Henry Mah als Mr. Koji |
| Garrett Masuda als Japanese Ghost Boy |
 | John Reardon als Jeremiah |
 | Campbell Lane als Amos |
| Catherine Barroll als Female Elder #1 |
 | Anna Ferguson als Female Elder #2 |
| Sean Allan als Male Elder #2 |
 | Ralph Alderman als Male Elder #3 |
| Brad Sihvon als 'His Brother, The Sheriff!' |
| Dave Leach als Mordecai |
 | Andrew McNee als Hoss |
| Tomoko Sato als Japanese Ghost Woman |
 | Edward Moss als Michael Jackson |
| Dru Williams als Cindy's Husband |
 | Debra Wilson als Oprah |
 | Laura Dash als Saw Villain - Alien |
| David Mylrea als Zoltar / 'I'll Pay You' |
 | Craig Mazin als Saw Villain (voice) |
 | David Zucker als Zoltar (voice) |
| Michael McDonald als Tiffany Stone |
| Champagne Powell als Don King |
| Steve Archer als Secret Service Agent |
 | Tim Henry als Dock Foreman |
 | Alex Bruhanski als Tiffany's Trainer |
 | Doug Abrahams als Fight Referee |
 | Blaine Anderson als Vendor at Fight |
 | Dale Wolfe als Hang Gliding Man |
| Ann Warn Pegg als 'Were You Naked?' |
 | Jess McLeod als Little Girl |
 | David MacKay als 'Alien Attack!' |
 | Tony Ali als Terrorist |
 | Jana Mitsoula als Running Woman #1 |
| Sharon Simms als Running Woman #2 |
| Mark Burgess als 'My Bowels Have Stopped Moving!' |
| Wes Taylor als Marilyn's New Husband |
 | Gwenda Lorenzetti als Mr. Koji's Assistant |
 | Brenda McDonald als Old Lady Henderson |
| Tim O'Halloran als Pigface Joe |
 | Darren Rizzolo als Spit Take Kid #1 |
| Adam Cannel als Spit Take Kid #2 |
| Sadie Decoste als Spit Take Kid #3 |
| Michelle Grigor als Spit Take Kid #4 |
| Leandro Iddrisu als Spit Take Kid #5 |
| Justin Callan als Spit Take Kid #6 |
 | Yan-Kay Crystal Lowe als Chingy's Girl #1 |
 | Christie Laing als Chingy's Girl #2 |
 | Angelique Naude als Chingy's Really Hot Waitress |
 | Dexter Bell als Chingy's Hype Man |
 | Beverley Breuer als Blonde Woman in Alien Basket |
| Scott Barratt als Fight Announcer |
 | Barry W. Levy als National Spokesman |
 | Darryl Scheelar als Shotgun Man |
 | Rorelee Tio als Yoko |
| Steve Kiziak als Tom's Neighbor #1 |
 | Link Baker als Tom's Neighbor #2 |
| Kimberley Buchanan als Tom's Neighbor #3 |
 | Kathryn Dobbs als School Teacher |
 | Tony Morelli als Ball Scratcher |
| Tina Hosford als Wet T-Shirt Girl #1 |
 | Elisa King als Wet T-Shirt Girl #2 |
| Andrea Morrow als Wet T-Shirt Girl #3 |
| Monica Dillon als Mahalik's Grandmother |
 | Sarah Edmondson als Bar Waitress |
 | Kwesi Ameyaw als Soldier |
 | Ted Friend als Reporter |
| Daniel Bruce als Belgian Minister |
| Chic Gibson als UN Diplomat #1 |
 | Robbie Segulam als UN Diplomat #2 |
 | Nimet Kanji als UN Diplomat #3 |
| Gabriela Cerecero als UN Diplomat #4 |
| Michael Ikeda als UN Diplomat #5 |
 | Mina E. Mina als UN Diplomat #6 |
| Ahmad Sharmrou als UN Diplomat #7 |
| Steadwick D'Penha als UN Diplomat #8 |
| Gregory Bennett als Russian Diplomat |
| Uget Ebony als UN Diplomat #10 |
| George Grove als Doctor |
 | Charlie Sheen als Tom Logan (uncredited) |
 | James Earl Jones als Narrator (uncredited) |
 | Patrice O'Neal als Rasheed (uncredited) |
 | Chris Williams als Marcus (uncredited) |
| Mashiah Vaughn-Hulbert als Principal (uncredited) |
 | Kimani Ray Smith als Cut Man (uncredited) |
 | Yaroslav Poverlo als Belgian Representative in UN (uncredited) |
 | Amber Borycki als Dancer (uncredited) |
| Thomas E. Ackerman | Director of Photography |
| David Zucker | Director |
| Jim Abrahams | Screenplay |
| Pat Proft | Screenplay |
| James L. Venable | Original Music Composer |
| Tom Lewis | Editor |
| Craig Mazin | Screenplay |
| Craig Herring | Editor |
| Craig Mazin | Producer |
| James Bamford | Stunts |
| Harvey Weinstein | Executive Producer |
| Shannon Gottlieb | Set Decoration |
| Carol Ramsey | Costume Design |
| Robert K. Weiss | Producer |
| Bob Weinstein | Executive Producer |
| Phil Dornfeld | Associate Producer |
| Nikolette Orlandou | Associate Producer |
| Grace Gilroy | Co-Producer |
| Holger Gross | Production Design |
| Roger Mussenden | Casting |
| William Heslup | Art Direction |
| Keith Christiansen | Sculptor |
| Rob Fournier | Armorer |
| Robert Milicevic | Security |
| Brenda Ilic | Visual Effects Coordinator |
| Sean M. Harding | First Assistant Camera |
| Jeffrey J. Dashnaw | Stunt Coordinator |
| Leah Graham | Production Coordinator |
| Steven Ticknor | Sound Designer |
| Joe Aleck | Grip |
| Angelina P. Cameron | Hairstylist |
| Graham Coutts | Property Master |
| Kim Olsen | Key Grip |
| Jeff Harvey | Best Boy Electric |
| Roderick Matte | Boom Operator |
| Maggie Rodford | Music Supervisor |
| Mat Beck | Visual Effects Supervisor |
| Adam Catt | Set Dressing Artist |
| Ryan Bailey | Gaffer |
| Geoff Teoli | Location Manager |
| Hamilton Sterling | Supervising Sound Editor |
| Rick Kramer | Greensman |
| Suzette Barnett | Compositor |
| Brigitte Prochaska | Unit Publicist |
| Toby Gorman | Lighting Technician |
| Grace Gilroy | Production Manager |
| Mark Jacyszyn | Production Supervisor |
| Gail Irvine | Props |
| Ellen Falguiere | Assistant Costume Designer |
| Nikki Amoriasino | Special Effects Coordinator |
| Gian Ganziano | Visual Effects Editor |
| Kevin Clark | Leadman |
| Liz Farrell | Key Hair Stylist |
| James Morioka | Sound Effects Editor |
| Paal Anand | 3D Artist |
| Andrew Emde | Assistant Art Director |
| Mike McLeod | Construction Foreman |
| Chris Beach | Set Designer |
| Stan Edmonds | Makeup Artist |
| David Crone | Camera Operator |
| Rebeccah Delchambre | Key Makeup Artist |
| Luisa Dalmagro | Set Costumer |
| Dave Bozman | Driver |
| Joshua Levinson | Post Production Supervisor |
| Mary Jo Macvey | Studio Teacher |
| Danny Torres | Systems Administrators & Support |
| Brian Dixon | Scoring Mixer |
| Michael Magill | Dialogue Editor |
| Steve Eathorne | First Assistant Director |
| Jeff Maynard | Digital Intermediate |
| Trevor Addie | Stunts |
| Christian P. Minkler | Sound Re-Recording Mixer |
| Aura Pithart | Stand In |
| Vicki Galloway Weimer | Executive Visual Effects Producer |
| Martine Bilodeau | Scenic Artist |
| Sean Oxenbury | Rigging Gaffer |
| Mark Berrow | Musician |
| Alison O'Brien | Visual Effects Producer |
| Danielle de Smit | Script Supervisor |
| Steve Ellis | Transportation Captain |
| Matthew Stein | Executive In Charge Of Production |
| Shawn Sykora | Foley Editor |
| Jim Schultz | Music Editor |
| Doug Hardwick | Construction Coordinator |
| Darren Michaels | Still Photographer |
| Samuel R. Harrison III | Video Assist Operator |
| Murray Brown | Sound Mixer |
| Angela Schneider | Art Department Assistant |
| Anneke Van Oort | Art Department Coordinator |
| Jennifer Grossman | Costume Supervisor |
| Martin Astles | Makeup Effects |
| Jordan Acomba | First Assistant Editor |
| Robert Althoff | Sound Recordist |
| Don Anderson | Assistant Property Master |
| Jan Holmsten | Construction Buyer |
| Nelson Dewey | Storyboard Artist |
| James Moriana | Foley Artist |
| Mo Henry | Negative Cutter |
| Harvey Lowry | Director of Operations |
| Ellie Fox | Payroll Accountant |
| Tami Treadwell | ADR Recordist |
| John Cluff | Special Effects Assistant |
| Tyler Woeste | Second Assistant Camera |
| Peter Kwong | Assistant Editor |
| Ray Scalice | General Manager |
| Ellen Anderson | Costumer |
| Alex Gibson | Supervising Music Editor |
| Dean Collins | Key Rigging Grip |
| Dawn Climie | Costume Set Supervisor |
| Daniel Mansfield | Third Assistant Director |
| Ryan Monro | Dolly Grip |
| Nick Ingman | Conductor |
| Zack Fox | Assistant Production Coordinator |
| Reid Paul | Digital Effects Producer |
| Steve Hutchins | Rotoscoping Artist |
| Dan Keeler | Special Effects Best Boy |
| Denise Horta | ADR Editor |
| Susie McIlwaine | Location Production Assistant |
| Jason Dunn | Matte Painter |
| Sam Restivo | Post Production Coordinator |
| Jeff Barnes | Production Executive |
| Rita Ciccozzi | First Assistant Makeup Artist |
| Daniel Abramson | Production Assistant |
| Mark DeSimone | ADR Mixer |
| Phil Dornfeld | Second Unit Director |
| Carmen Lavender | Sound Assistant |
| Ryan Bozajian | VFX Artist |
| Rik Panero | I/O Manager |
| Lori C. Miller | Title Designer |
| Kirk Chiswell | Assistant Camera |
| Devin Sterling | Digital Intermediate Producer |
| Darcy Woodley | Animal Wrangler |
| Jill McQueen | First Assistant Production Coordinator |
| Anne-Marie Leidl | Graphic Designer |
| Chris Hampton | Special Effects Technician |
| Dan Gorval | Best Boy Grip |
| Everette Webber | Digital Intermediate Editor |
| Jane Pearson | Assistant Accountant |
| Jeremy Peirson | Additional Sound Re-Recording Mixer |
| Andrew Bock | First Assistant Sound Editor |
| Avram D. Gold | Supervising ADR Editor |
| Melissa Kostenbauder | Casting Assistant |
| Andrew S. Eisen | Associate Editor |
| Sandra Couldwell | Extras Casting |
| Norm Li | Camera Trainee |
| Corey Robson | Digital Imaging Technician |
| Robert Blye | CG Animator |
| Renee Bella | Assistant Location Manager |
| Beverly Bernacki | Digital Compositor |
| Ali Dunn | Stunt Double |
| Tony Morelli | Stunt Coordinator |
| Doug Chapman | Stunts |
| Crystal Dalman | Stunts |
| Janene Carleton | Stunts |
| Andrea Kinsky | Stunts |
| Krista Bell | Stunts |
| Larissa Stadnichuk | Stunts |
| Eli Zagoudakis | Stunt Double |
| Chris Webb | Stunts |
| Mathew Yanagiya | Stunts |
| Dan Shea | Stunts |
| Darren E. Scott | Stunts |
| Sharon Simms | Stunts |
| Rick Pearce | Stunts |
| Jovan Nenadic | Stunts |
| Brad Kelly | Stunts |
| Terrance Leigh | Stunt Double |
| Beverly Knight | Stunts |
| Kathy Hubble | Stunts |
| Michelle Jeanpierre | Stunts |
| Nicholas Harrison | Stunt Double |
| Leif Havdale | Stunts |
| Duane Dickinson | Stunts |
| Tommy Europe | Stunts |
| Ashlea Earl | Stunts |
| Bruce Crawford | Stunts |
| Janina Dall | Stunts |
| Laura Lee Connery | Stunt Double |
| Alex Chiang | Stunts |
| Colby Chartrand | Stunts |
| Kimberly Chiang | Stunts |
| Nesta Chapman | Stunts |
| Brett Chan | Stunts |
| Raymond Chan | Stunts |
| Celia Bond | Stunts |
| Rene Bishop | Stunts |
| Byron Brisco | Stunts |
| Chad Bellamy | Stunts |
| Tanya Allen | Stunts |
| Tanya Allen | Stunt Double |
| Rikki Gagne | Stunts |
| Rorelee Tio | Stunts |
| Jeff Sanca | Stunt Double |
