 | Scott Innes als Scooby-Doo / Shaggy Rogers (voice) |
 | Frank Welker als Fred Jones (voice) |
 | Grey DeLisle als Daphne Blake (voice) |
 | B.J. Ward als Velma Dinkley (voice) |
 | Mikey Kelley als Bill McLemore (voice) |
 | Tom Kane als Professor Robert Kaufman (voice) |
 | Bob Bergen als Eric Staufer (voice) |
 | Joe Alaskey als Officer Wembley (voice) |
 | Gary Anthony Sturgis als Phantom Virus (voice) |
| Mark Turosz | Writer |
| Jim Stenstrum | Director |
| Louis Febre | Original Music Composer |
| Joe Gall | Editor |
| Kathryn Page | Associate Producer |
| Joseph Barbera | Characters |
| William Hanna | Characters |
| William Hanna | Executive Producer |
| Joseph Barbera | Executive Producer |
| Jean MacCurdy | Executive Producer |
| Davis Doi | Producer |
| Leslie Lamers | Casting |
| Kazuya Hoshi | Camera Operator |
