 | Frank Welker als Scooby-Doo / Fred Jones / Dynomutt (voice) |
 | Mindy Cohn als Velma Dinkley (voice) |
 | Grey DeLisle als Daphne Blake (voice) |
 | Matthew Lillard als Shaggy Rogers (voice) |
 | Diedrich Bader als Brad Adams (voice) |
 | Dee Bradley Baker als Hideous Hyde Hound / Horten / Minotaur (voice) |
 | Jeff Bennett als Owen Garrison (voice) |
 | Gregg Berger als Hank Prince / Zorak (voice) |
 | John DiMaggio als Mr. Hyde (voice) |
 | Nika Futterman als Jennifer Severin (voice) |
 | Kevin Michael Richardson als Mayor Ron Starlin (voice) |
 | Mindy Sterling als Caterer (voice) |
 | Tara Strong als Austin / Princess Garogflotach (voice) |
 | Fred Tatasciore als Jack Rabble / Cruel Dynomutt (voice) |
 | Billy West als Becker (voice) |
| Michael Goguen | Director |
| Tristin Cole | Background Designer |
| James Tucker | Producer |
| Kristopher Carter | Original Music Composer |
| Michael McCuistion | Original Music Composer |
| Lolita Ritmanis | Original Music Composer |
| Dawn Hershey | Casting |
| Kyle Stafford | Editor |
| Ted Blackman | Art Direction |
| Eric Semones | Art Direction |
| Marly Halpern-Graser | Story |
| Michael Ryan | Teleplay |
| Alan Burnett | Co-Producer |
| Jason Wyatt | Line Producer |
| Sam Register | Executive Producer |
| Dan Haskett | Character Designer |
| James Stenstrum | Character Designer |
| James Tucker | Character Designer |
| Ben Maloney | Production Manager |
| Scott Shinick | Post-Production Manager |
| Mark A. Keatts | Supervising Dialogue Editor |
| Mark A. Keatts | ADR Editor |
| Kelly Ann Foley | Dialogue Editor |
| Kelly Ann Foley | ADR Editor |
| Patrick J. Foley | Dialogue Editor |
| Patrick J. Foley | ADR Editor |
| Michael Garcia | Dialogue Editor |
| Michael Garcia | ADR Editor |
| Mark Mattson | Music Arranger |
| Mako Sujishi | Music Arranger |
| Steven White | Online Editor |
| Niki Sherrod | Other |
| Nicole Martin | Administration |
| Liz Carroll | Administration |
| Bobbie Page | Production Supervisor |
| Ed Adams | Production Manager |
| Jay Bastian | Executive In Charge Of Production |
| Jeff Prezenkowski | Executive In Charge Of Production |
| Joe Ruby | Thanks |
| Ken Spears | Thanks |
