 | David Arquette als Dewey Riley |
 | Neve Campbell als Sidney Prescott |
 | Courteney Cox als Gale Weathers |
 | Patrick Dempsey als Mark Kincaid |
 | Scott Foley als Roman Bridger |
 | Lance Henriksen als John Milton |
 | Matt Keeslar als Tom Prinze |
 | Jenny McCarthy-Wahlberg als Sarah Darling |
 | Emily Mortimer als Angelina Tyler |
 | Parker Posey als Jennifer Jolie |
 | Deon Richmond als Tyson Fox |
 | Kelly Rutherford als Christine Hamilton |
 | Liev Schreiber als Cotton Weary |
 | Patrick Warburton als Steven Stone |
 | Jamie Kennedy als Randy Meeks |
 | Roger L. Jackson als Ghostface (voice) |
 | Julie Janney als Moderator |
 | Richmond Arquette als Student |
 | Nancy O'Dell als Female Reporter |
 | Ken Taylor als Male Reporter |
 | Lynn McRee als Maureen Roberts Prescott / Rina Reynolds |
 | Roger Corman als Studio Executive |
 | Josh Pais als Wallace |
| John Embry als Stage Security Guard |
 | Lawrence Hecht als Neil Prescott |
| Lisa Beach als Studio Tour Guide |
 | Kevin Smith als Silent Bob |
 | Jason Mewes als Jay |
| Erik Erath als Stan |
| Daniel K. Arredondo als Office Security Guard |
| Lisa Gordon als Waitress |
 | Heather Matarazzo als Martha Meeks |
 | Carrie Fisher als Bianca Burnette |
 | C.W. Morgan als Hank Loomis |
 | Beth Toussaint als Female Caller (voice) |
 | Wes Craven als Man with Video Camera on Studio Tour (uncredited) |
| Strawberry Fields als Tourist (uncredited) |
| Cathy Konrad | Producer |
| Lisa Beach | Casting |
| Sarah Katzman | Casting Associate |
| Bill Abbott | Music Editor |
| Bob Weinstein | Executive Producer |
| Harvey Weinstein | Executive Producer |
| Marco Beltrami | Original Music Composer |
| Daniel Lupi | Production Manager |
| Wes Craven | Director |
| Gene Serdena | Set Decoration |
| Ehren Kruger | Screenplay |
| Bruce Alan Miller | Set Designer |
| Doc Kane | ADR Mixer |
| Paul Hughen | Second Unit Director of Photography |
| Scott Andrew Ressler | First Assistant Camera |
| Michael LaViolette | Chief Lighting Technician |
| Philip Sloan | First Company Grip |
| Tim Collins | Dolly Grip |
| Paul Wilkowsky | Grip |
| Peter Deming | Director of Photography |
| Sloane U'Ren | Set Designer |
| Tim Chau | Sound Re-Recording Mixer |
| Thomas Fichter | Art Direction |
| Kevin Williamson | Producer |
| Kevin Williamson | Characters |
| Marianne Maddalena | Producer |
| Nicholas Mastandrea | First Assistant Director |
| Patrick Lussier | Editor |
| Abigail Murray | Costume Design |
| Kathrine Gordon | Hair Department Head |
| Nathan Easterling | Assistant Editor |
| Tabby Hanson | Stunts |
| Rick Avery | Stunt Coordinator |
| Rick Avery | Second Unit Director |
| G.W. Brown | Supervising ADR Editor |
| Albert Gasser | Sound Editor |
| John Kwiatkowski | Sound Editor |
| Todd Toon | Sound Designer |
| Todd Toon | Supervising Sound Editor |
| Erik Cord | Stunts |
| Jim Chesney | Transportation Co-Captain |
| Steven Lambert | Stunts |
| Laura Albert | Stunts |
| Spiro Razatos | Stunts |
| David Kern | Sound Editor |
| Kimberly Adams | Assistant Costume Designer |
| Nancy Deren | Set Designer |
| David Ghegan | Electrician |
| Jake Garber | Makeup Effects |
| Dan O'Connell | Foley Artist |
| Grant Samson | Leadman |
| Hazel Catmull | Hairstylist |
| John Kurlander | Scoring Mixer |
| Piero Mura | Sound Editor |
| John T. Cucci | Foley Mixer |
| Andy D'Addario | Sound Re-Recording Mixer |
| Derek Raser | Transportation Coordinator |
| Claudia Bestor | Art Department Coordinator |
| Leslie Huntley | Visual Effects Producer |
| Ray McIntyre Jr. | Visual Effects Supervisor |
| Robert J. Carlyle | Construction Coordinator |
| Jennifer Badger | Stunts |
| Jennifer Badger | Stunt Double |
| Lori Rowbotham | Assistant Art Director |
| Tina Anderson | Post Production Coordinator |
| Sheila Waldron | Script Supervisor |
| Rico Torres | Still Photographer |
| Howell Gibbens | ADR Editor |
| Gene Warren Jr. | Visual Effects Supervisor |
| J.P. Jones | Property Master |
| Donald J. Malouf | Sound Editor |
| Craig B. Ayers Sr. | Greensman |
| Ron Bolanowski | Special Effects Coordinator |
| Ken Glassing | Camera Operator |
| Robert W. Anderson | Set Dresser |
| Steven Samanen | Graphic Designer |
| Reid Paul | Compositing Supervisor |
| Tony Bacigalupi | First Assistant Editor |
| Carol Schwartz | Makeup Department Head |
| Patti Hawn | Unit Publicist |
| Dana Reed | Stunts |
| Sarah Mays | Makeup Artist |
| Robert Consing | Storyboard Artist |
| Daniel K. Arredondo | Second Assistant Director |
| Rosemary C. Cremona | Second Unit First Assistant Director |
| Cesar Orozco | Propmaker |
| Adam Kay | Music Editor |
| Patrick Murphy | Digital Compositor |
| Ed Gerrard | Music Supervisor |
| Jim Stuebe | Sound Mixer |
| Lesa Nielsen | Makeup Artist |
| Mark Van Loon | Steadicam Operator |
| Suzanne Cranfill | Set Costumer |
| Elisha Gruer | Casting Assistant |
| Mark Sadler | Lighting Technician |
| Lisa Hoyle | Stunt Double |
| Robert Dawson | Title Designer |
| Joni Avery | Stunts |
| F. Scott Taylor | Assistant Sound Editor |
| Donna Cicatelli-Lewis | Key Makeup Artist |
| Michelle Sebek | Stunts |
| Michelle Sebek | Stunt Double |
| Robert C. Decker | Location Manager |
| Ilt Jones | Location Manager |
| Mark A. Tracy | First Assistant Sound Editor |
| David Diamond | Boom Operator |
| Monica Castro | Assistant Property Master |
| Michael Glynn | Set Dresser |
| Anthony D. Parrillo | Set Designer |
| J.T. Thayer | Transportation Captain |
| Jane Austin | Stunts |
| Ray Rarick | Construction Foreman |
| Mary Albee | Stunts |
| George Capetanos | Set Dresser |
| Gloria O'Brien | Stunts |
| Gloria O'Brien | Stunt Double |
| Bruce Harris | Digital Compositor |
| Eric Sandlin | Assistant Chief Lighting Technician |
| Jennifer Bender | Extras Casting |
| Quinn Yarbrough | Set Dresser |
| Tammy Brady Conrad | Stunts |
| Terri Cadiente | Stunts |
| Eugene B. Kerry | Grip |
| David Dietch | Set Costumer |
| Gerald Gates Jr. | Painter |
| Edward Tamayo | Set Dresser |
| Barbara Ann Spencer | Set Designer |
