 | Tobey Maguire als Red Pollard |
 | David McCullough als Narrator |
 | Jeff Bridges als Charles Howard |
 | Chris Cooper als Tom Smith |
 | Elizabeth Banks als Marcela Howard |
 | Gary L. Stevens als George Woolf |
 | Eddie Jones als Samuel D. Riddle |
 | William H. Macy als Tick Tock McGlaughlin |
 | Royce D. Applegate als Dutch Doogan |
| Chris McCarron als Charley Kurtsinger |
 | Michael Ensign als Steamer Owner |
 | Jesse Hernandez als Male Mariachi Band |
 | Paul Vincent O'Connor als Bicycle Supervisor |
 | Ed Lauter als Charles Strub |
 | Michael O'Neill als Mr. Pollard |
 | Annie Corley als Mrs. Pollard |
 | Valerie Mahaffey als Annie Howard |
 | Michael Angarano als Young Red Pollard |
 | Dyllan Christopher als Frankie Howard |
 | Matt Miller als Pimlico Starter |
 | Gary Ross als Pimlico Track Announcer |
 | Michael B. Silver als Baltimore Doctor |
 | Jay Cohen als Bugle Player |
 | Cameron Bowen als Pollard Child |
| Carl M. Craig als Sam |
| David Doty als Land Broker |
 | James Keane als Car Customer |
| Mariah Bess als Pollard Child |
 | Noah Luke als Pollard Child |
| Hans Howes als White Horse Trainer |
 | Finder's Key als Seabiscuit |
| Jane Sindell | Producer |
| Roger Birnbaum | Executive Producer |
| Judianna Makovsky | Costume Design |
| Tobey Maguire | Executive Producer |
| Gary Ross | Screenplay |
| Gary Ross | Director |
| John Schwartzman | Director of Photography |
| Leslie A. Pope | Set Decoration |
| Frank Marshall | Producer |
| Andrew Neskoromny | Art Direction |
| Gary Ross | Producer |
| Gary Barber | Executive Producer |
| Allison Thomas | Executive Producer |
| Randy Newman | Original Music Composer |
| Laura Hillenbrand | Novel |
| Robin Bissell | Executive Producer |
| William Goldenberg | Editor |
| Jeannine Oppewall | Production Design |
| Debra Zane | Casting |
| Michael Lantieri | Special Effects Coordinator |
| Tom Pahk | Special Effects Supervisor |
| Marcia Patten | Costume Supervisor |
| David R. Christensen | Gaffer |
| Eric Withee | Visual Effects Coordinator |
| Rick Harris | Rigging Grip |
| Carolyn Elias | Hair Department Head |
| Scott Lampert | Camera Operator |
| Kurt E. Soderling | Helicopter Camera |
| Frank Dorowsky | Rigging Gaffer |
| Donald Elliott | Special Effects Supervisor |
| Lydia Milars | Makeup Artist |
| Cari Thomas | Visual Effects Producer |
| Kim Lee | Visual Effects Producer |
| Julie Pitkanen | Script Supervisor |
| Susan Germaine | Hairstylist |
| Lisa Tomczeszyn | Assistant Costume Designer |
| Thomas Nellen | Makeup Department Head |
| Sian Grigg | Makeup Artist |
| June Bracken | Makeup Artist |
| Terri Taylor | Casting |
| Richard R. Hoover | Visual Effects Supervisor |
| Francine Byrne | Art Department Coordinator |
| Circe Mirano | Art Department Coordinator |
| Joani Yarbrough | Hairstylist |
| Andrea Maxwell | Visual Effects Editor |
| Shane Brott | Rigging Grip |
| Colleen Kelsall | Assistant Costume Designer |
| Michael Scheffe | Visual Effects Art Director |
| Andrew Rowlands | Steadicam Operator |
| Justin Holdsworth | Gaffer |
| Ian Fox | Camera Operator |
| François Duhamel | Still Photographer |
| Margo Baxley | Costume Supervisor |
| Michael Stone | Camera Operator |
| Randall D. Wilkins | Set Designer |
| Tod A. Maitland | Production Sound Mixer |
| Peter Staubli | Sound Effects Editor |
| Anna Behlmer | Sound Mixer |
| Scott Sanders | Sound Effects Editor |
| Per Hallberg | Supervising Sound Editor |
| Silvio Wolf Busch | Stunt Coordinator |
| Ezra Dweck | Sound Effects Editor |
| Bruce Tanis | Sound Effects Editor |
| Mitchell Amundsen | Second Unit Director of Photography |
| Jonathan Chibnall | First Assistant Editor |
| Dan Hegeman | Sound Effects Editor |
| Christopher Assells | Sound Effects Editor |
| Andy Nelson | Sound Mixer |
| Karen Baker Landers | Supervising Sound Editor |
| Dan Bradley | Stunt Coordinator |
| Adam Somner | First Assistant Director |
| Robert Renga | Sound Recordist |
| Steven Melton | Property Master |
| Chris Jargo | ADR Supervisor |
| David A. Cohen | ADR Editor |
| Anna MacKenzie | ADR Editor |
| Craig Heath | Sound Recordist |
| Bill Roe | Second Unit Director of Photography |
| Chris Hogan | Dialogue Editor |
| Constance A. Kazmer | Dialogue Editor |
| Kimaree Long | Dialogue Editor |
| Dino DiMuro | Sound Effects Editor |
| Kathleen Kennedy | Producer |
| Mark W. Jones | Driver |
| Gary Archer | Prosthetics |
| Jay Cohen | Musician |
| Basti Van Der Woude | Second Assistant Director |
| Heather Burton | Stunts |
| David Leitch | Stunts |
| Tad Griffith | Stunts |
| Dan Bradley | Second Unit Director |
