 | Will Smith als Ben |
 | Rosario Dawson als Emily |
 | Woody Harrelson als Ezra Turner |
 | Michael Ealy als Ben's Brother |
 | Barry Pepper als Dan |
 | Elpidia Carrillo als Connie |
 | Robinne Lee als Sarah |
 | Bill Smitrovich als George Ristuccia |
 | Joe Nuñez als Larry |
 | Sarah Jane Morris als Susan |
 | Connor Cruise als Young Ben |
 | Tim Kelleher als Stewart Goodman |
 | Gina Hecht als Dr. Briar |
 | Andy Milder als George's Doctor |
 | Judyann Elder als Holly |
 | Madison Pettis als Connie's Daughter |
 | Octavia Spencer als Kate the Home Health Care Nurse |
 | Robert Ochoa als Choirboy (uncredited) |
 | Bojana Novaković als Julie |
| Todd Black | Producer |
| Jason Blumenthal | Producer |
| Philippe Le Sourd | Director of Photography |
| Angelo Milli | Original Music Composer |
| Gabriele Muccino | Director |
| Will Smith | Producer |
| Grant Nieporte | Screenplay |
| Hughes Winborne | Editor |
| Martha Callender | Makeup Artist |
| Angela Demo | Casting |
| David F. Klassen | Art Direction |
| Sharen Davis | Costume Design |
| Leonard Drake | Hairstylist |
| J. Michael Riva | Production Design |
| Leslie A. Pope | Set Decoration |
| Carol DePasquale | Script Supervisor |
| Alicia M. Tripi | Hairstylist |
| Renee J. Vaca | Hairstylist |
| Denise Chamian | Casting |
| Judy Murdock | Makeup Department Head |
| Steve Hart | Stunt Double |
| James Lassiter | Producer |
| Steve Tisch | Producer |
| David Crockett | Executive Producer |
| David Bloomfield | Executive Producer |
| Ken Stovitz | Executive Producer |
| Domenico Procacci | Executive Producer |
| Molly Allen | Co-Producer |
| Chrissy Blumenthal | Co-Producer |
| Eddie Braun | Stunt Coordinator |
| David Crockett | Unit Production Manager |
| Jeffrey Wetzel | First Assistant Director |
| Paul Schneider | Second Assistant Director |
| Randolph LeRoi | Stunts |
| Jeff Valeri | Production Supervisor |
| Tracey Nyberg | Associate Producer |
| Hope M. Parrish | Property Master |
| Kirk R. Gardner | "A" Camera Operator |
| Kirk R. Gardner | Steadicam Operator |
| Bob Hall | First Assistant "A" Camera |
| Daniel C. McFadden | Second Assistant "A" Camera |
| Patrick McArdle | First Assistant "B" Camera |
| Tim Guffin | Second Assistant "B" Camera |
| Aaron Schuh | Camera Loader |
| Elaine Ramires | Costume Supervisor |
| Jodie Stern | Key Costumer |
| Valerie Zielonka | Key Costumer |
| Yvonne Bastidos | Costumer |
| Mitzi Haralson | Costumer |
| Iva Marques | Costumer |
| Robert Mata | Costumer |
| Pierce Austin | Hair Department Head |
| David Jarrell | Chief Lighting Technician |
| Andy Dorowsky | Rigging Gaffer |
| Tasso Bravos | Key Rigging Grip |
| Jim Stuebe | Production Sound Mixer |
| Kevin Hyde | Boom Operator |
| John Frazier | Special Effects Coordinator |
| Kei Rowan-Young | Location Manager |
| Tom Carson | Production Coordinator |
| Monica Muehlhause-Horn | Production Accountant |
| Walt Hadfield | Construction Coordinator |
| Chris Samp | Standby Painter |
| Dawn Ascher-Trevino | Art Department Coordinator |
| Russell R. Anderson | Leadman |
| Paul Rylander | Assistant Property Master |
| Cid Swank | Unit Publicist |
| Merrick Morton | Still Photographer |
| Sabrina Hyman | Casting Assistant |
| Raymond Bulinski | Craft Service |
| Jim Chesney | Transportation Captain |
| Joe Feeney | Transportation Co-Captain |
| Conrad E. Palmisano | Second Unit Director |
| Josh Bleibtreu | Second Unit Director of Photography |
| John Breinholt | First Assistant Editor |
| Heather Mullen | Assistant Editor |
| Dennis Drummond | Supervising Sound Editor |
| Tim Tuchrello | Assistant Sound Editor |
| Kim Drummond | Supervising ADR Editor |
| Mark Yardas | Dialogue Editor |
| D. Chris Smith | Sound Designer |
| Dan Yale | Foley Editor |
| Brian Armstrong | Foley Editor |
| Gary A. Hecker | Foley Artist |
| Pamela Kahn | Foley Artist |
| Mike Marino | Foley Mixer |
| Kyle Rochlin | Foley Mixer |
| Howard London | ADR Mixer |
| Brian Smith | ADR Mixer |
| Tateum Kohut | Sound Re-Recording Mixer |
| Greg Orloff | Sound Re-Recording Mixer |
| Rick Kline | Sound Re-Recording Mixer |
| Carlton Kaller | Music Editor |
| Jim Schultz | Music Editor |
| Mo Henry | Negative Cutter |
| Jill Bogdanowicz | Digital Colorist |
| Danny Braet | Visual Effects Supervisor |
| Henry Kingi | Stunts |
