 | Robert Downey Jr. als Sherlock Holmes |
 | Jude Law als Dr. John Watson |
 | Rachel McAdams als Irene Adler |
 | Mark Strong als Lord Henry Blackwood |
 | Eddie Marsan als Inspector Lestrade |
 | Robert Maillet als Dredger |
 | Geraldine James als Mrs. Hudson |
 | Kelly Reilly als Mary Morstan |
 | William Houston als Constable Clark |
 | Hans Matheson als Lord Coward |
 | James Fox als Sir Thomas Rotheram |
 | William Hope als Ambassador Standish |
 | Clive Russell als Captain Tanner |
 | Oran Gurel als Reordan |
 | David Garrick als McMurdo |
 | Ky Discala als Maid |
 | Andrew Brooke als Guard Captain |
 | Tom Watt als Carriage Driver |
 | John Kearney als Carriage Driver |
 | Sebastian Abineri als Coach Driver |
 | Jonathan Gabriel Robbins als Guard |
 | James A. Stephens als Captain Philips |
 | Terence Taplin als Groundskeeper |
 | Bronagh Gallagher als Palm Reader |
 | Ed Tolputt als Anonymous Man |
 | Joe Egan als Big Man |
 | Jefferson Hall als Young Guard |
 | Miles Jupp als Waiter |
 | Marn Davies als Police Officer |
 | Andrew Greenough als Prison Guard |
 | Ned Dennehy als Man with Roses |
 | Martin Ewens als Removable Man |
| Amanda Grace Johnson als Young Woman Sacrifice |
 | James Greene als Governor |
 | David Emmings als Grave Policeman |
 | Ben Cartwright als Grave Policeman |
 | Chris Sunley als Grave Policeman |
 | Michael Jenn als Preacher |
 | Timothy O'Hara als Porter / Smith |
 | Guy Williams als Golden Dawn Envoy |
 | Peter Miles als Thug |
 | Rocco Ritchie als Boy in the Street (uncredited) |
| Guy Ritchie | Director |
| Anthony Peckham | Screenplay |
| Simon Kinberg | Screenplay |
| Lionel Wigram | Screenstory |
| Michael Robert Johnson | Screenstory |
| Arthur Conan Doyle | Characters |
| Bruce Berman | Executive Producer |
| Michael Tadross | Executive Producer |
| Dana Goldberg | Executive Producer |
| Susan Downey | Producer |
| Dan Lin | Producer |
| Joel Silver | Producer |
| Lionel Wigram | Producer |
| Peter Eskelsen | Producer |
| Steve Clark-Hall | Producer |
| Michael Robert Johnson | Screenplay |
| James Herbert | Editor |
| Philippe Rousselot | Director of Photography |
| Sarah Greenwood | Production Design |
| Jenny Beavan | Costume Design |
| Reg Poerscout-Edgerton | Casting |
| Alex Bailey | Still Photographer |
| Katie Spencer | Set Decoration |
| Kevin Kaska | Orchestrator |
| James Foster | Art Direction |
| Nick Gottschalk | Art Direction |
| Matthew Gray | Art Direction |
| Niall Moroney | Supervising Art Director |
| Christine Blundell | Hair Designer |
| Carol 'Ci Ci' Campbell | Hairstylist |
| Charmaine Fuller | Hairstylist |
| Chloe Meddings | Hairstylist |
| Paul Mooney | Hairstylist |
| Lesa Warrener | Hairstylist |
| Julia Wilson | Hairstylist |
| Patricia Regan | Makeup Artist |
| Lesa Warrener | Makeup Artist |
| Julia Wilson | Makeup Artist |
| Christine Blundell | Makeup Designer |
| Des Whelan | Camera Operator |
| Alan Stewart | Second Unit Director of Photography |
| Vince McGahon | Steadicam Operator |
| Neal Norton | Steadicam Operator |
| Jack English | Chief Lighting Technician |
| Collin Quinlan | Chief Lighting Technician |
| Louis Sabat | Dolly Grip |
| Julian Bucknall | First Assistant Camera |
| Olly Tellett | First Assistant Camera |
| Bobby Mancuso | First Assistant Camera |
| Chuck Finch | Gaffer |
| David Sinfield | Gaffer |
| John Flemming | Key Grip |
| George Patsos | Key Grip |
| Nick Ray | Key Grip |
| Tommy Finch | Rigging Gaffer |
| Greg Quinlan | Rigging Gaffer |
| Gus Magalios | Rigging Grip |
| Emma Callinan | Casting Assistant |
| Charlotte Law | Assistant Costume Designer |
| Melissa Meister | Assistant Costume Designer |
| Martin Mandeville | Costume Coordinator |
| Clare Spragge | Costume Supervisor |
| Valentina Aulisi | Set Costumer |
| Peter White | Set Costumer |
| Arlynn Abseck | Wardrobe Supervisor |
| Nick Jeffries | Armorer |
| Elizabeth West | Script Supervisor |
| Polly Hope | Script Supervisor |
| Dadi Einarsson | Animation Supervisor |
| Rick Leary | CG Supervisor |
| Laurent Hugueniot | CG Supervisor |
| Day Yargici | 2D Artist |
| Sarah Tulloch | Visual Effects Coordinator |
| Chloe Harrison | Visual Effects Coordinator |
| Laura Jennings | Visual Effects Editor |
| Pawl Fulker | Pre-Visualization Supervisor |
| Daniel Barrow | Visual Effects Producer |
| Claudia Dehmel | Visual Effects Producer |
| Alexandra Daunt Watney | Visual Effects Producer |
| Tim Keene | Visual Effects Producer |
| Chas Jarrett | Visual Effects Supervisor |
| David Vickery | Visual Effects Supervisor |
| Jonathan Fawkner | Visual Effects Supervisor |
| Jeff Brink | Special Effects Coordinator |
| Mark Holt | Special Effects Supervisor |
| Luke Neuman | Boom Operator |
| Andrew Schmetterling | Boom Operator |
| Paul Munro | Boom Operator |
| Steve Little | Dialogue Editor |
| Becki Ponting | Dialogue Editor |
| Derek Trigg | Foley Editor |
| Michael Fentum | Sound Designer |
| Dominic Gibbs | Sound Effects Editor |
| Andy Kennedy | Sound Effects Editor |
| Ron Bartlett | Sound Re-Recording Mixer |
| Doug Hemphill | Sound Re-Recording Mixer |
| James Mather | Supervising Sound Editor |
| Matthew Bristowe | Digital Intermediate |
| Todd Kleparski | Digital Intermediate |
| Philip Hedgecock | First Assistant Editor |
| Peter Oso Snell | Music Editor |
| Gabi Brown | Art Department Coordinator |
| Joseph K. Kepple IV | Art Department Coordinator |
| Matthew Robinson | Assistant Art Director |
| Helen Xenopoulos | Assistant Art Director |
| Michael Auszura | Assistant Art Director |
| Toni Barton | Assistant Art Director |
| Bradley Schmidt | Assistant Art Director |
| John McDonnell | Assistant Property Master |
| Robert Griffon Jr. | Property Master |
| Dennis Wiseman | Property Master |
| Steve Finn | Boom Operator |
| Richard Ryan | Stunts |
| Richard Dwyer | Stunts |
| Elliot Scott | Runner Art Department |
| Joseph S. Alfieri | Construction Coordinator |
| Michael Bloomberg | Thanks |
| Helen Steinway Bailey | Stunts |
| Jodi Michelle Pynn | Stunts |
| Heather Phillips | Stunts |
| Stephanie Lelievre | Stunts |
| Nina Armstrong | Stunts |
| Nadia Stacey | Other |
| Hans Zimmer | Original Music Composer |
| Ed Colyer | Foley Mixer |
| Peter Burgis | Foley Artist |
| Glen Gathard | Foley Mixer |
| Matt Gruber | Sound Re-Recording Mixer |
| Chris Munro | Sound Mixer |
| Nick Foley | ADR Mixer |
| Chris Lyons | Special Effects Makeup Artist |
| Nathaniel De'Lineadeus | Special Effects Makeup Artist |
| Matthew Smith | Prosthetic Makeup Artist |
| Nadia Stacey | Makeup Artist |
| Siân Miller | Makeup Artist |
| Sian Milne | Stunts |
