 | Mike Myers als Shrek (voice) |
 | Eddie Murphy als Donkey (voice) |
 | Cameron Diaz als Princess Fiona (voice) |
 | Antonio Banderas als Puss in Boots (voice) |
 | Walt Dohrn als Rumpelstiltskin / Priest / Krekraw Ogre (voice) |
 | Julie Andrews als Queen Lillian (voice) |
 | John Cleese als King Harold (voice) |
 | Jon Hamm als Brogan (voice) |
 | Jane Lynch als Gretched (voice) |
 | Craig Robinson als Cookie (voice) |
 | Lake Bell als Patrol Witch / Wagon Witch #2 (voice) |
 | Kathy Griffin als Dancing Witch / Wagon Witch #1 (voice) |
 | Mary Kay Place als Guard Witch (voice) |
 | Kristen Schaal als Pumpkin Witch / Palace Witch (voice) |
 | Meredith Vieira als Broomsy Witch (voice) |
 | Ryan Seacrest als Father of Butter Pants (voice) |
 | Cody Cameron als Pinocchio / Three Pigs (voice) |
 | Larry King als Doris (voice) |
 | Regis Philbin als Mabel (voice) |
 | Christopher Knights als Blind Mice (voice) |
 | Conrad Vernon als Gingerbread Man (voice) |
 | Aron Warner als Wolf (voice) |
 | Jasper Johannes Andrews als Ogre Baby (voice) |
| Ollie Mitchell als Ogre Baby (voice) |
 | Miles Bakshi als Ogre Baby / Villager Kid (voice) |
| Nina Zoe Bakshi als Ogre Baby / Tourist Girl / Villager Girl (voice) |
 | Billie Hayes als Cackling Witch (voice) |
| Jeremy Hollingworth als Villager Fan #1 (voice) |
| Brian Hopkins als Villager Fan #3 / Ogre Gnimrach (voice) |
 | Chris Miller als Royal Messenger / Magic Mirror / Geppetto (voice) |
 | Mike Mitchell als Tour Guide / Camp Ogre / Ogre Naysayer / Baba Witch / Melty Witch / Witch Guard #2 / Butter Pants (voice) |
 | James Ryan als Villager Fan #2 (voice) |
 | Ashley Boettcher als Witch (voice) / Pedestrian (voice) (uncredited) |
| Danielle Soibelman als Witch (voice) / Pedestrian (voice) (uncredited) |
 | Frank Welker als Dragon / Animals (voice) (uncredited) |
| Josh Klausner | Writer |
| Darren Lemke | Writer |
| Mike Mitchell | Director |
| Steve Cunningham | Animation |
| Josh LaBrot | Layout |
| Teresa Cheng | Producer |
| Andrew Adamson | Executive Producer |
| Aron Warner | Executive Producer |
| Gina Shay | Producer |
| John H. Williams | Executive Producer |
| Tony Cosanella | Production Manager |
| Doug Cooper | Visual Effects Supervisor |
| Michael Hernandez | Art Direction |
| Harry Gregson-Williams | Original Music Composer |
| Nick Fletcher | Editor |
| Peter Zaslav | Production Design |
| Ethan van der Ryn | Supervising Sound Editor |
| Erik Aadahl | Supervising Sound Editor |
| Leslee Feldman | Casting |
| Max Boas | Art Direction |
| William Steig | Book |
| Patty Kaku | Associate Producer |
| Andy Nelson | Sound Mixer |
| Anna Behlmer | Sound Mixer |
| Yong Duk Jhun | Layout Supervisor |
| Walt Dohrn | Head of Story |
| David Yanover | Post Production Supervisor |
| Terry Rossio | Characters |
| Ryan Harris | Story Supervisor |
| Peter McCown | Production Supervisor |
| Ted Elliott | Characters |
| Danielle Helsaple | Production Supervisor |
| Kelly Matthews | Production Supervisor |
| Andrew Adamson | Characters |
| Andrew Birch | Post-Production Manager |
| Joe Crowley | Production Supervisor |
| Sunny Ye | Production Supervisor |
| Monica Hada | Post-Production Manager |
| David Soren | Post Production Supervisor |
| Angelique Yen | Department Administrator |
| Mary M. Quinn | Script Supervisor |
| Malia P. Russell | Production Supervisor |
| Joe Stillman | Characters |
| Tracey Dispensa | Production Supervisor |
| Roger S.H. Schulman | Characters |
| Robyn Mesher | Production Supervisor |
| Laura Hofmann | Production Supervisor |
| April Lawrence | Production Supervisor |
