 | Leonardo DiCaprio als Edward Teddy Daniels |
 | Mark Ruffalo als Chuck Aule |
 | Ben Kingsley als Dr. John Cawley |
 | Max von Sydow als Dr. Naehring |
 | Michelle Williams als Dolores |
 | Emily Mortimer als Rachel Solando (1) |
 | Patricia Clarkson als Rachel 2 |
 | Jackie Earle Haley als George Noyce |
 | Ted Levine als Warden |
 | John Carroll Lynch als Deputy Warden McPherson |
 | Elias Koteas als Andrew Laeddis |
 | Robin Bartlett als Bridget Kearns |
 | Christopher Denham als Peter Breene |
 | Nellie Sciutto als Nurse Marino |
 | Joseph Sikora als Glen Miga |
 | Curtiss Cook als Trey Washington |
 | Raymond Anthony Thomas als Orderly Ganton |
 | Joseph McKenna als Inmate Billings |
 | Ruby Jerins als Little Girl |
 | Tom Kemp als Ward C Guard |
 | Bates Wilder als Ward C Guard |
 | Lars Gerhard als Dying Commandant |
 | Matthew Cowles als Ferry Captain |
 | Jill Larson als Manacled Woman |
 | Ziad Akl als Tattoo'd Man |
 | Dennis Lynch als Red-Haired Man |
| John Porell als Wild-Eyed Man |
| Aidan Cole Mitchell als Younger Boy |
| Drew Beasley als Younger Boy |
 | Joseph P. Reidy als Operator |
 | Bree Elrod als Female Patient |
| Thomas B. Duffy als Guard |
 | Ken Cheeseman als Doctor |
 | Steve Witting als Doctor |
| Michael E. Chapman als Patient |
 | Keith Fluker als Orderly |
| Darryl Wooten als Orderly |
 | Michael Byron als McPherson's Driver |
 | Gary Galone als Gate Guard |
 | Gabriel Hansen als Young Guard |
 | Dan Marshall als U.S. G.I. at Dachau Liberation / German S.S. Officer Killed (uncredited) |
 | Harrison Young als Psychiatric Patient (uncredited) |
 | John Franchi als Criminally Insane Inmate (uncredited) |
| Dennis Lehane | Novel |
| Laeta Kalogridis | Screenplay |
| Sandy Powell | Costume Design |
| Martin Scorsese | Director |
| Mike Medavoy | Producer |
| Martin Scorsese | Producer |
| Dante Ferretti | Production Design |
| Arnold Messer | Producer |
| Robert Richardson | Director of Photography |
| Manlio Rocchetti | Makeup Department Head |
| Ellen Lewis | Casting |
| Louis Phillips | Executive Producer |
| Francesca Lo Schiavo | Set Decoration |
| Christina Ann Wilson | Art Direction |
| Jerry Popolis | Hair Department Head |
| Thelma Schoonmaker | Editor |
| Larry McConkey | Steadicam Operator |
| Tom Fleischman | Sound Re-Recording Mixer |
| Jennifer Dunnington | Music Editor |
| Philip Stockton | Supervising Sound Editor |
| Max Biscoe | Art Direction |
| Robbie Robertson | Music Supervisor |
| Eugene Gearty | Supervising Sound Editor |
| Andrew Cooper | Still Photographer |
| Meghan Rafferty | Casting Associate |
| Robert Guerra | Supervising Art Director |
| Robin Citrin | Location Manager |
| Jamie Baker | Foley Editor |
| Scott Getzinger | Property Master |
| Kam Chan | Foley Editor |
| Fred Rosenberg | Dialogue Editor |
| Barbra Matis | Assistant Art Director |
| Robert Legato | Second Unit Director of Photography |
| Matthew H. O'Connor | Marine Coordinator |
| Shannon Blake Gans | Visual Effects Producer |
| David Sanger | Visual Effects Producer |
| Martha Pinson | Script Supervisor |
| Marissa Littlefield | Supervising ADR Editor |
| Kathryn Blondell | Hairstylist |
| Patricia Woodbridge | Assistant Art Director |
| Ian Kincaid | Chief Lighting Technician |
| Curtis Lindersmith | Digital Intermediate |
| Al Cerullo | Pilot |
| Llyr Tobias Johansen | Visual Effects Coordinator |
| Jonathan Stone | Visual Effects Producer |
| Matthew Gratzner | Visual Effects Supervisor |
| Robert Cuddy | Electrician |
| Marianne Bower | Researcher |
| Michael S. Roberts | Rigging Grip |
| Yvan Lucas | Digital Intermediate |
| Randall Balsmeyer | Title Designer |
| Guillaume DeLouche | Armorer |
| Hinju Kim | Assistant Art Director |
| Adam Watkins | CG Supervisor |
| Ariane Rosier | Visual Effects Coordinator |
| Dave Provenzano | Electrician |
| R. Bruce Steinheimer | Special Effects Coordinator |
| Wenden K. Baldwin | Visual Effects Editor |
| John Cowell | Ager/Dyer |
| Dianna Reardon | Ager/Dyer |
| Petur Hliddal | Sound Mixer |
| Duke Scoppa | Assistant Property Master |
| Alan D'Angerio | Hairstylist |
| Michael Jortner | Assistant Property Master |
| Thomas A. Morris Jr. | Construction Coordinator |
| Ben Grossmann | Visual Effects Supervisor |
| Kim Kono | Electrician |
| Jack McPhee | Electrician |
| Patricia Regan | Key Makeup Artist |
| Marion Kolsby | Assistant Art Director |
| Robert Legato | Visual Effects Supervisor |
| Jose 'Flecha' Hernandez | Electrician |
| Lisa Padovani | Assistant Costume Designer |
| Tobias Haller | Rigging Grip |
| Bettina Hastie | Tailor |
| Magdalena Wolf | Visual Effects Producer |
| Daniel Pershing | Dolly Grip |
| Denise Andres | Costume Supervisor |
| Chris Taft | Digital Intermediate |
| Sian Grigg | Makeup Artist |
| Luke McDonald | CG Supervisor |
| Paula Diane Lopez | Visual Effects Coordinator |
| Ron Ames | Visual Effects Producer |
| Andrew Bell | Rigging Grip |
| David Davenport | Costume Supervisor |
| Scott Brock | First Assistant Editor |
| James P. Meehan | Armorer |
| Cathy Scorsese | Assistant Property Master |
| Paul Graff | Visual Effects Supervisor |
| Simone Perusse | Electrician |
| R. Scott Forster | Rigging Grip |
| Debbie Holbrook | Key Costumer |
| Ann Powderly | Tailor |
| Tom Reiser | Digital Intermediate |
| David Fencl | Armorer |
| Christine Fennell | Key Hair Stylist |
| Christina Graff | Visual Effects Producer |
| Joni M. Huth | Tailor |
| Stephen Mann | Stunt Double |
| Robert Chapin | Digital Effects Supervisor |
| Amy Herman | First Assistant Director |
| Amy Lauritsen | Second Assistant Director |
| Robert Legato | Second Unit Director |
| Freida Orange | Second Second Assistant Director |
| Joseph P. Reidy | First Assistant Director |
| John Silvestri | Second Assistant Director |
| G. A. Aguilar | Stunt Coordinator |
| Chris Barnes | Stunts |
| George B. Colucci Jr. | Stunt Double |
| Blaise Corrigan | Stunt Coordinator |
| Matthew C Dumond | Stunt Double |
| Mark Fichera | Stunt Double |
| Jeffrey Lee Gibson | Stunts |
| Stephen Leavins | Stunt Double |
| Paul Marini | Stunt Double |
| Ian Mclaughlin | Stunts |
| Michael Duarte | Grip |
| William L. Flanagan | Grip |
| Sean Hadley | Grip |
| Hugh McCallum | Grip |
| David C. Romano | Grip |
| Ed Searles | Grip |
| Wilfredo Usuga | Grip |
| Wayne Brackett | Set Dresser |
| Joseph DeLuca | Set Dresser |
| Paul Alexander Larkin | Set Dresser |
| Gabor Medveczky | Set Dresser |
| Julio Daniel Rodriguez | Set Dresser |
| Susan Garfield | Stand In |
| Brad Fischer | Producer |
