 | Radha Mitchell als Rose Da Silva |
 | Sean Bean als Christopher Da Silva |
 | Jodelle Ferland als Sharon / Alessa |
 | Laurie Holden als Cybil Bennett |
 | Deborah Kara Unger als Dahlia Gillespie |
 | Kim Coates als Officer Thomas Gucci |
 | Tanya Allen als Anna |
 | Alice Krige als Christabella |
 | Nicky Guadagni als Distressed Woman |
 | Maxine Dumont als Christabella's Aide |
 | Chris Britton als Adam |
| Colleen Williams als Archivist |
 | Ron Gabriel als Old Mechanic |
 | Derek Ritschel als Young Police Officer |
 | Eve Crawford als Sister Margaret |
 | Amanda Hiebert als Gas Attendant |
 | Roberto Campanella als Red Pyramid / Janitor / Colin |
 | Stephen R. Hart als Elder |
 | Janet Land als Congregation |
 | Elizabeth Harpur als Congregation |
 | Hannah Fleming als School Girl |
 | Lorry Ayers als Scarred Older Alessa |
 | Melissa Panton als Dark Nurse |
 | Rhoslynne Bugay als Dark Nurse |
 | Chantelle Leonardo als Dark Nurse |
 | Carrie Eklund als Dark Nurse |
| Florence MacGregor als Congregation |
| Lynn Woodman als Congregation |
| Holly Makarchuk als School Girl |
| Tatiana Haas als School Girl |
| Michael Cota als Armless Man |
| Yvonne Ng als Grey Child |
| Emily Lineham als Red Nurse / Dark Nurse |
| Donna Milburn als Slashing Dark Nurse |
| Nadia Barosso als Dark Nurse |
| Noelle Boggio als Dark Nurse |
| Victoria Boland als Dark Nurse |
| Alicia Bundy als Dark Nurse |
| Rachel Crowther als Dark Nurse |
| Zsuzsanna Cseh als Dark Nurse |
| Judit Kovacs als Dark Nurse |
| Stephanie Lauder als Dark Nurse |
| Onika Ndukwe als Dark Nurse |
| Kat Olsen als Dark Nurse |
| Sylwia Pluta als Dark Nurse |
| Lisa Shaw als Dark Nurse |
| Tamara Smeaton als Dark Nurse |
| Nicole Ann St. Hill als Dark Nurse |
| Samantha Hayes als School Girl (uncredited) |
| Victor Sutton als Undead man (uncredited) |
| Dana Jones | Stunts |
| Patrick Tatopoulos | Creature Design |
| Steve Lucescu | Creature Design |
| Ciara Jones | Stunts |
| Lesley Krueger | Creature Design |
| Samuel Hadida | Producer |
| Carol Spier | Production Design |
| Christophe Gans | Director |
| Simon Board | Second Unit |
| Maxine Dumont | Stunts |
| Deb LeFaive | Line Producer |
| Dan Laustsen | Director of Photography |
| Daniele Massaccesi | Camera Operator |
| Andrew Mason | Executive Producer |
| Roger Avary | Writer |
| Don Carmody | Producer |
| Roberto Campanella | Creature Design |
| Kym Kristalie | Stunts |
| Wendy Partridge | Costume Design |
| Dean Copkov | Stunts |
| Pierre Henry | First Assistant Editor |
| Thierry Segur | Creature Design |
| Sébastien Prangère | Editor |
| Deirdre Bowen | Casting |
| Deb LeFaive | Production Manager |
| Akira Yamaoka | Executive Producer |
| Nicolas Boukhrief | Creature Design |
| Shane Cardwell | Stunts |
| Plato Fountidakis | Stunts |
| Brian Jagersky | Stunts |
| Brian Kaulback | Stunts |
| Martin Hume | Camera Operator |
| Ben Gervais | Creature Design |
| Marco Bianco | Stunts |
| Michael Blatchford | Camera Loader |
| Akira Yamaoka | Music |
| Chris Bridges | Makeup Effects |
| Sean Sansom | Makeup Effects |
| Melissa Girotti | Production Coordinator |
| James McAteer | Art Direction |
| John Bannister | Scenic Artist |
| Paul Germann | Sound Effects Editor |
| Monty Montgomerie | Key Grip |
| Annie Wilkinson | Studio Teachers |
| Rocco Larizza | Special Effects |
| Akiko Wilson | Makeup Artist |
| Todd Beckett | Sound Re-Recording Mixer |
| Robert Warchol | Sound Effects Editor |
| Jean-Xavier Hasson | Visual Effects Editor |
| Dave Bouskill | Rigging Gaffer |
| Samantha Timmerman | Script Supervisor |
| Rose-Mary Gubala | Makeup Artist |
| Paul Jones | Makeup Effects Designer |
| Patrick Tatopoulos | Makeup Effects Designer |
| Jill Purdy | ADR Editor |
| Holly Radcliffe | Visual Effects Producer |
| Dusty Reeves | Art Department Coordinator |
| David McCallum | ADR & Dubbing |
| Natasha North | Visual Effects Coordinator |
| Kevin Banks | Music Editor |
| Dawn E. Rivard | Wigmaker |
| Lou Solakofski | Sound Re-Recording Mixer |
| Steve Lucescu | Stunt Coordinator |
| Rafy | Still Photographer |
| Nicolas Becker | Sound Designer |
| Garrett Kerr | ADR Editor |
| Mishann Lau | Sound Editor |
| Mark Shnuriwsky | Sound Editor |
| Thomas Care | Dolly Grip |
| Al Vrkljan | Armorer |
| Michael Madden | Set Designer |
| Mark Zsifkovits | Sound Re-Recording Mixer |
| Charles Taylor | Armorer |
| Lara Voloshin | Production Coordinator |
| Bruce Shapiro | Dialect Coach |
| Kevin Haeberlin | Leadman |
| Grant Van Der Slagt | Set Designer |
| Jason McFarling | Boom Operator |
| Tony Mederos | Sound Effects Editor |
| Denis Bedlow | First Assistant Editor |
| Sarah Craig McEathron | Makeup Effects |
| Denis Bellingham | Boom Operator |
| Ken Yasumoto | Sound Designer |
| Jonathan Matthews | Location Manager |
| Karola Dirnberger | Key Hair Stylist |
| C.J. Goldman | Makeup Effects |
| Pierre Henry | First Assistant Director |
| Christopher Geggie | Property Master |
| Rod Crombie | Steadicam Operator |
| François Daignault | Camera Operator |
| Paul Pattison | Key Makeup Artist |
| Roderick Deogrades | Sound Effects Editor |
| Jane Tattersall | Supervising Sound Effects Editor |
| David Gauthier | Special Effects Supervisor |
| Bryan Forde | Gaffer |
| Elinor Rose Galbraith | Art Direction |
| Peter Nicolakakos | Set Decoration |
| Dave Olivares | Modeling |
| Tig Fong | Stunts |
| Simon Board | Second Assistant Director |
| Miguel Ortega | 3D Modeller |
| Jeff Danna | Original Music Composer |
| Jennifer Vey | Stunt Double |
| Keiichiro Toyama | Original Concept |
| Keiichiro Toyama | Original Story |
| Victor Hadida | Executive Producer |
| Kathy Choi | Sound Editor |
| Brent Pickett | Sound Editor |
| David Caporale | Sound Editor |
| Steve Medeiros | Sound Editor |
| Andy Malcolm | Foley Artist |
| Goro Koyama | Foley Artist |
| Don White | Foley Mixer |
| Stephane Ceretti | VFX Supervisor |
| Bret Culp | VFX Supervisor |
| Kyle Menzies | VFX Supervisor |
| Lon Molnar | VFX Supervisor |
| Noel Hooper | VFX Supervisor |
| Mike Shand | VFX Supervisor |
