 | George Clooney als Chris Kelvin |
 | Natascha McElhone als Rheya |
 | Viola Davis als Gordon |
 | Jeremy Davies als Snow |
 | Ulrich Tukur als Gibarian |
 | Michael Ensign als Friend |
 | John Cho als DBA Emissary |
 | Morgan Rusler als DBA Emissary |
 | Shane Skelton als Gibarian's Son |
 | Donna Kimball als Mrs. Gibarian |
 | Elpidia Carrillo als Friend |
 | Kent Faulcon als Patient |
 | Lauren Cohn als Patient |
 | Jennie Baek als Passenger (uncredited) |
| Tony Clemons als Dinner Guest (uncredited) |
| Dale Hawes als Pedestrian (uncredited) |
| Annie Morgan als Nurse (uncredited) |
| Antonio Rochira als Party Guest (uncredited) |
 | Jude S. Walko als City Dweller (uncredited) |
| Steven Soderbergh | Director |
| Steven Soderbergh | Screenplay |
| James Cameron | Producer |
| Cliff Martinez | Original Music Composer |
| Steven Soderbergh | Director of Photography |
| Steven Soderbergh | Editor |
| Debra Zane | Casting |
| Steve Arnold | Art Direction |
| Keith P. Cunningham | Art Direction |
| Rae Sanchini | Producer |
| Jon Landau | Producer |
| Stanisław Lem | Novel |
| Philip Messina | Production Design |
| Milena Canonero | Costume Design |
| Kristen Toscano Messina | Set Decoration |
| Wylie Griffin | Art Department Coordinator |
| Sean Haworth | Assistant Art Director |
| Aaron Sowd | Conceptual Design |
| Chris Snyder | Construction Coordinator |
| John Pospisil | Sound Editor |
| Paul Urmson | Sound Editor |
| Larry Blake | Supervising Sound Editor |
| Kevin Hannigan | Special Effects Coordinator |
| Jonathan Gerber | CG Supervisor |
| Kenji Sweeney | 3D Supervisor |
| Chris Bailey | Animation Supervisor |
| John Hewitt | CG Supervisor |
| Bill Murphy | Visual Effects Coordinator |
| Steve Rhee | Visual Effects Editor |
| Melissa Brockman | Visual Effects Producer |
| Gary Nolin | Visual Effects Producer |
| Thomas J. Smith | Visual Effects Supervisor |
| Richard E. Hollander | Visual Effects Supervisor |
| Werner Hahnlein | Special Effects Supervisor |
| Vaughn Williams | Special Effects Supervisor |
| Duane Manwiller | Camera Operator |
| Bob Marshak | Still Photographer |
| James Plannette | Gaffer |
| R. Michael De Chellis | Rigging Gaffer |
| Bobby Brown | First Assistant Camera |
| Kent Baker | Rigging Grip |
| Michael L. Lewin | Rigging Grip |
| Terri Taylor | Casting Associate |
| Eduardo Castro | Assistant Costume Designer |
| Jordanna Fineberg | Assistant Costume Designer |
| Shoshana Rubin | Set Costumer |
| Corey Bronson | Set Costumer |
| David Kirchner | First Assistant Editor |
| Kathrine Gordon | Hair Department Head |
| Waldo Sanchez | Hairstylist |
| Julie Hewett | Makeup Department Head |
| Christien Tinsley | Makeup Artist |
| Kimberly R. McCord-Wilson | Dialogue Editor |
| Duane Manwiller | Second Unit Director of Photography |
| Paul Ledford | Production Sound Mixer |
| Gregory Jacobs | Executive Producer |
| Gregory Jacobs | First Assistant Director |
| Basti Van Der Woude | Second Assistant Director |
| Larry Blake | Sound Re-Recording Mixer |
| David Betancourt | Foley Mixer |
| Matt Coby | Sound Assistant |
| Dawn Fintor | Foley Artist |
| Jay Gallagher | Sound Assistant |
| Mick Gormaley | Assistant Sound Editor |
| Randall L. Johnson | Boom Operator |
| Alex Names | Utility Sound |
| Eric Potter | Sound Effects |
| Nicholas Renbeck | Sound Editor |
| Alicia Stevenson | Foley Artist |
| Derek Casari | ADR Engineer |
| Shawn Holden | Additional Sound Re-Recording Mixer |
| Julie M. Anderson | Production Supervisor |
| Monica de Armond | Post Production Supervisor |
| Michael Polaire | Unit Production Manager |
| Trey Batchelor | Second Unit First Assistant Director |
| Garnet Baril | Special Effects Technician |
| Manuel S. Epstein | Special Effects Technician |
| David Escher | Special Effects Technician |
| Lucinda Foy | Special Effects Technician |
| Manuela Hahnlein | Special Effects Coordinator |
| William D. Harrison | Special Effects Technician |
| Al Marangoni | Special Effects Technician |
| David A. Poole | Special Effects Technician |
| Ron Rosegard | Special Effects Technician |
| Anthony Simonaitis | Special Effects Technician |
| Ken Tarallo | Special Effects Technician |
| Tim Walkey | Special Effects Technician |
| Vaughn Williams | Special Effects Technician |
| Gunter Anderson | Special Effects Technician |
| Michael Roundy | Special Effects Coordinator |
| Paul Vigil | Special Effects Coordinator |
| Tim Ziegenbein | Special Effects Manager |
| Bill Cobb | Special Effects Manager |
| Mike Malone | Set Dresser |
| Benedict C. Adams | Machinist |
| Dale E. Anderson | Set Dresser |
| Dawn Brown | Set Designer |
| Kirk Corwin | Property Master |
| Andrea Dopaso | Set Designer |
| Michael Jon Duffin | Construction Foreman |
| Louie Esparza | Painter |
| Dan Engle | Sculptor |
| Steven Eustace | Carpenter |
| Mike Bomar | Paint Coordinator |
| Tim Flattery | Conceptual Illustrator |
| Hank Giardina | Paint Coordinator |
| Larry Haney | Set Dresser |
| John Harrington | Assistant Property Master |
| Steve Gindorf | Propmaker |
| Bill 'Kauhane' Hoyt | Painter |
| Blair Huizingh | Assistant Art Director |
| Helen Kozora | Set Buyer |
| Steven Ladish | Set Dresser |
| Lance Larson | Assistant Property Master |
| Victor James Martinez | Set Designer |
| Jeff Ozimek | Set Designer |
| Edward V. Pannozzo | Accountant |
| Edward J. Protiva | Set Dresser |
| Eric Ramirez | Leadman |
| Quentin Schierenberg | Set Dresser |
| Lissette Schettini | Set Decorating Coordinator |
| Easton Michael Smith | Set Designer |
| Suzan Wexler | Set Designer |
| Robert Woodruff | Assistant Art Director |
| James W. Apted | Second Assistant Camera |
| John Atkins | Electrician |
| Russell Ayer | Lighting Technician |
| Dana Baker | Best Boy Grip |
| Kent Baker | Key Rigging Grip |
| Tony Blaszczyk | Rigging Grip |
| Joseph Capshaw | Electrician |
| Will Dearborn | Loader |
| Seong Dilg | Grip |
| Craig Doobie | Grip |
| Brent Ekstrand | Playback Coordinator |
| Peter Freeman | Lighting Technician |
| Martin Garner | Playback Coordinator |
| Stanley L. Gonsales | Best Boy Electric |
| Raymond Gonzales | Lighting Technician |
| Michael Grady | Rigging Grip |
| Steve House | Rigging Grip |
| Barry Idoine | First Assistant Camera |
| David Jensen | Grip |
| Robert Lackey | Lighting Technician |
| Al LaVerde | Key Grip |
| Jonathan Leary | Rigging Grip |
| Michelle LeDoux | Lighting Technician |
| Ken Mann | Electrician |
| Damon Marcellino | Best Boy Electric |
| Larry Markart | Playback Coordinator |
| Mark Mele | Electrician |
| Ken Metz | Grip |
| Bruton Peterson | Electrician |
| Eric Sagot | Best Boy Electric |
| Paul Threlkeld | Dolly Grip |
| Paul Vakay III | Electrician |
| Joe L. Wright | Best Boy Grip |
| Bobby Brown | First Assistant "B" Camera |
| James Barrett | Electrician |
| Andrew Dumas | Second Assistant Camera |
| Chris Hults | Lighting Technician |
| Yuri Karjane | Assistant Camera |
| Michael L. Lewin | Grip |
| Erin Toner | Casting Assistant |
| Rich King | Extras Casting |
| Corey Bronson | Costumer |
| Mike Chapman | Costume Supervisor |
| Greg Curry | Colorist |
| Suzanne Debrunner | Post Production Assistant |
| Susan Littenberg | Associate Editor |
| Vincent Mourou | Assistant Editor |
| Dan Muscarella | Color Timer |
| Tim Streeto | Assistant Editor |
| Harold Lee Yen | Post Production Assistant |
| Norman R. Walker | Assistant Editor |
| Dava Whisenant | Post Production Assistant |
| Aaron Scully | Post Production Assistant |
| Alex Apple | Assistant Location Manager |
| Greg Kappy | Assistant Location Manager |
| Christian Krieger | Assistant Location Manager |
| James R. Maceo | Location Manager |
