 | Jeff Daniels als Charles Driggs |
 | Melanie Griffith als Audrey Hankel |
 | Ray Liotta als Ray Sinclair |
 | George 'Red' Schwartz als Counter Man |
 | Margaret Colin als Irene |
| Leib Lensky als Frenchy |
 | Tracey Walter als The Country Squire |
| Maggie T. als Country Squire Bulldog |
| Patricia Falkenhain als Charlie's Secretary |
 | Sandy McLeod als Graves' Secretary |
 | Robert Ridgely als Richard Graves |
| Buzz Kilman als TV Newscaster |
 | Kenneth Utt als Dad |
| Adelle Lutz als Rose |
 | Charles Napier als Irate Chef |
| Jim Roche als Motel Philosopher |
 | John Sayles als Motorcycle Cop |
 | John Waters als Used Car Guy |
| The Texas Kid als Hitchhiking Cowboy |
| Byron D. Hutcherson als Hitchhiking Kid |
| Eleana Hutcherson als Hitchhiking Kid |
| Thomas Cavano als Guitar Player |
| Dorothy Demme als Junk Store Gal |
| Emma Byrne als Junk Store Gal |
 | Dana Preu als Peaches |
| Mary Ardella Drew als Donna Penski |
| Joseph Lee Davis als James Williams |
 | Edward Saxon als Kevin Stroup |
| James Hurd als Stylish Reunion Couple |
| Joanna Kitchen-Hurd als Stylish Reunion Couple |
 | Jack Gilpin als Larry Dillman |
| Su Tissue als Peggy Dillman |
 | Gary Goetzman als Guido Paonessa |
| Chloe Amateau als Chloe |
| Dung Chau als Robbery Victim |
| Steven Scales als Nelson |
| John Montgomery als Harmonica Slim |
| Kristin Olsen als Tracy |
| Heather Shaw als Choir Girl |
| Vic Blair als Cowboy Maitre d' |
| D. Stanton Miranda als Darlene |
| Ding-a-Ling als Motorcycle Dog |
| Johnny Marrs als Motorcycle Driver |
| George Henry Wyche Jr. als Police Officer |
| Marilee K. Smith als Police Officer |
| Jeffrey R. Rioux als Police Officer |
| Jeff Herig als Police Officer |
| Gil Lazier als Homicide Detective |
 | Anna Thomson als The Girl in 3F |
 | 'Sister' Carol East als Dottie |
| Jonathan Demme | Director |
| Jonathan Demme | Producer |
| Edward Saxon | Executive Producer |
| Kenneth Utt | Producer |
| Laurie Anderson | Original Music Composer |
| John Cale | Original Music Composer |
| Tak Fujimoto | Director of Photography |
| Craig McKay | Editor |
| Norma Moriceau | Production Design |
| E. Max Frye | Writer |
| Bill Miller | Associate Producer |
| Ronald M. Bozman | Associate Producer |
| Stephen J. Lineweaver | Art Direction |
| William F. Reynolds | Set Decoration |
| Norma Moriceau | Costume Design |
| Risa Bramon Garcia | Casting |
| Billy Hopkins | Casting |
| Sandy McLeod | Script Supervisor |
| Kenneth Utt | Production Manager |
| Kyle McCarthy | Second Assistant Director |
| Ronald M. Bozman | First Assistant Director |
| Chip Taylor | Thanks |
| Kevin Oates | Set Dresser |
| Richard Adee | Set Dresser |
| Clay A. Griffith | Art Department Assistant |
| Kathy Bird | Art Department Assistant |
| Linda Murphy | Boom Operator |
| Les Lazarowitz | Sound Mixer |
| Frank Graziadei | Sound Recordist |
| Camilla Toniolo | Associate Producer |
| Tom Fleischman | Sound Re-Recording Mixer |
| Grace Blake | Production Office Coordinator |
| Tony C. Jannelli | Camera Operator |
| Billy Gerardo | Assistant Camera |
| Vinnie Gerardo | Assistant Camera |
| Don Smetzer | Still Photographer |
| S. Karin Epstein | Still Photographer |
| Ann Miller | Property Master |
| Kathleen Dolan | Assistant Property Master |
| Lewis 'Jiggs' Walker | Assistant Property Master |
| Winston 'Ford' Lawless | Assistant Property Master |
| Charles Meere III | Gaffer |
| John Smith | Best Boy Electric |
| Gene Engels | Electrician |
| Kurt Illinger | Electrician |
| Ken Beattie | Electrician |
| Bob Brennan | Best Boy Grip |
| James Finnerty | Dolly Grip |
| Jim Meade | Grip |
| Brian Marshall | Grip |
| Andrea 'Maude' Graham | Grip |
| John Donahue | Key Grip |
| Jerry Holt | Other |
| Peter Demme | Carpenter |
| Chuck Esty | Carpenter |
| Susan Wood | Scenic Artist |
| Jim Finguerra | Scenic Artist |
| Eugenie Bafaloukos | Costume Supervisor |
| Maria Rita Barbera | Wardrobe Supervisor |
| Michael Forcade | Wardrobe Supervisor |
| Julie Parker | Wardrobe Supervisor |
| Jacqueline Pinon | Wardrobe Supervisor |
| Gary Goetzman | Music Consultant |
| Sharon Boyle | Music Supervisor |
| Dan Sable | Supervising Sound Editor |
| Diane Schaub | First Assistant Editor |
| Rudy Gaskins | Assistant Editor |
| Alisa Lepselter | Other |
| Michael Moyse | Sound Editor |
| Paul Trejo | Sound Editor |
| Louis Bertini | Sound Assistant |
| Lynn Sable | Sound Assistant |
| Jill Searchinger | Sound Assistant |
| Harriet Winn | ADR Editor |
| Ann Stein | ADR Editor |
| Yvette Nabel | Other |
| Reilly Steele | ADR Recordist |
| Jacek Laskus | Creative Consultant |
| John Leonidas | Transportation Coordinator |
| Dennis Radesky | Transportation Captain |
| John Robotham | Stunt Coordinator |
| Tom Schurke | Other |
| Heidi Levitt | Casting Assistant |
| Lisa Peterson | Casting Assistant |
| Beth Cavano | Extras Casting |
| Reid Burns | Color Timer |
| David Byrne | Main Title Theme Composer |
