 | Ben Schwartz als Sonic the Hedgehog (voice) |
 | James Marsden als Tom Wachowski |
 | Tika Sumpter als Maddie Wachowski |
 | Jim Carrey als Dr. Robotnik |
 | Natasha Rothwell als Rachel |
 | Adam Pally als Wade Whipple |
 | Neal McDonough als Major Bennington |
 | Lee Majdoub als Agent Stone |
 | Tom Butler als Vice Chairman Walters |
 | Frank C. Turner als Crazy Carl |
 | Melody Nosipho Niemann als Jojo |
 | Shannon Chan-Kent als Roadhouse Waitress |
 | Brad Kelly als Roadhouse Thug |
 | Elfina Luk als Secretary of Homeland Security |
 | Garry Chalk als Navy Chief of Staff |
 | Michael Hogan als Air Force Chief of Staff |
 | Peter Bryant als Army Chief of Staff |
 | Jeremy Arnold als Businessman |
 | Jeanie Cloutier als Businesswoman |
 | Emma Oliver als Parisian Little Kid |
 | Bailey Skodje als Minivan Kid |
 | Dean Petriw als Minivan Kid |
 | Jeff Sanca als Minivan Dad |
 | Lisa Chandler als Minivan Mom |
| Chris Gailus als News Anchor |
 | Bethel Lee als Receptionist |
 | Anthony Santiago als Senior Glass Installer |
 | Jeremiah Oh als Junior Glass Installer |
| Charles Heffernan als Mime |
 | Terence Kelly als Farmer Zimmer |
 | Sean Campbell als Bartender |
 | Scott Patey als Bar Patron / On Set Sonic |
 | Sandy Robson als Bar Patron |
| Andrea Marcum als Yoga Instructor |
 | Benjamin Valic als Baby Sonic (voice) |
 | Donna Jay Fulks als Longclaw (voice) |
 | Colleen O'Shaughnessey als Miles 'Tails' Prower (voice) (uncredited) |
| Stephen F. Windon | Director of Photography |
| Pat Casey | Screenplay |
| Josh Miller | Screenplay |
| Grant Van Der Slagt | Art Direction |
| Tom Holkenborg | Original Music Composer |
| Jeff Fowler | Executive Producer |
| Tim Miller | Executive Producer |
| Toru Nakahara | Producer |
| Mie Onishi | Producer |
| Neal H. Moritz | Producer |
| Takeshi Ito | Producer |
| Kia Stuart | Stunts |
| Dean Bailey | Stunt Driver |
| Pete Antico | Stunts |
| Kory Grim | Stunts |
| Krista Bell | Stunt Driver |
| Tommy Clarke | Stunts |
| Ged Wright | Visual Effects Supervisor |
| Chris Uyede | Visual Effects Supervisor |
| Sean Haworth | Production Design |
| Jeff Fowler | Director |
| Jeanne McCarthy | Casting |
| Mariam Abdallah | Production Manager |
| Naoto Oshima | Characters |
| Haruki Satomi | Executive Producer |
| Rhonda Taylor | Unit Manager |
| Toby Ascher | Producer |
| Masanao Maeda | Executive Producer |
| Nicole Abellara Hallman | Casting |
| Nan Morales | Unit Production Manager |
| Lisa Rodgers | Post Production Supervisor |
| J. Michael Williams | Unit Production Manager |
| Chuck Williams | Associate Producer |
| Dan Jevons | Co-Producer |
| Peter Lyons Collister | Second Unit Director |
| Hirokazu Yasuhara | Characters |
| Krishnan Jay | Production Manager |
| Scott Catolico | Second Second Assistant Director |
| Jay Williams | First Assistant Director |
| Dmitri M. Johnson | Co-Producer |
| Mie Onishi | Associate Producer |
| Jordan Ballard | Post Production Assistant |
| Shamess Shute | First Assistant Director |
| Nan Morales | Executive Producer |
| Karina Rahardja | Co-Producer |
| Yuji Naka | Characters |
| Hajime Satomi | Executive Producer |
| Gurjit Chohan | Second Assistant Director |
| Haley Lauten | Assistant Director Trainee |
| Megan Schaufele | Third Assistant Director |
| Stacey Schroeder | Editor |
| Debra Neil-Fisher | Editor |
| Justin Muller | First Assistant Director |
| Tatiana Ragsdale | Assistant Director Trainee |
| Debra McGuire | Costume Designer |
| Denise Davis | Visual Effects Producer |
| Garvin Cross | Stunt Coordinator |
| Darryl Scheelar | Stunt Coordinator |
| Lars Grant | Stunts |
| Tim Cody | Stunts |
| Dave Hospes | Stunts |
| Douglas Armstrong | Stunts |
| Braden Haggerty | Stunts |
| Shiraine Haas | Stunts |
| Matt Reimer | Stunts |
| Dan Redford | Stunts |
| Brennan Walstrom | Stunts |
| Ryan Ennis | Stunts |
| Rhys Williams | Stunts |
| Colby Chartrand | Stunts |
| Tommy Europe | Stunts |
| Gerald Paetz | Stunts |
| Dexter Bell | Stunts |
| Rob 'Sluggo' Boyce | Stunts |
| David Jacox | Stunts |
| Tony Bailey | Stunts |
| Todd Scott | Stunts |
| Nilo Ghajar | Stunts |
| Curtis Braconnier | Stunts |
| Glenn Ennis | Stunts |
| Dan Payne | Stunts |
| Ron Robinson | Stunts |
| Chris Webb | Stunts |
| Leif Havdale | Stunts |
| Breanna Watkins | Stunts |
| Brian Jagersky | Stunts |
| Mike Mitchell | Stunts |
| Brynn Alexander | Stunts |
| Jean Frenette | Stunts |
| Robert Hayley | Stunts |
| Krista Bell | Stunts |
| Irma Leong | Stunts |
| Fraser Corbett | Stunts |
| Matt Kennedy | Stunts |
| Chelsea Jackson | Stunts |
| Landon Jackle | Stunts |
| Jason William Day | Stunts |
| Tamiko Brownlee | Stunts |
| Sabine Varnes | Stunts |
| Sharon Simms | Stunts |
| Daniel Cudmore | Stunts |
| Jared Payne | Stunts |
| John Stoneham Jr. | Stunts |
| Jolene Van Vugt | Stunts |
| Janene Carleton | Stunts |
| Randy Lee | Stunts |
| Laura Lee Connery | Stunts |
| Kai Hirvonen | Stunts |
| Owen Walstrom | Stunts |
| Bill Ferguson | Stunts |
| Dan Shea | Stunts |
| Chad Bellamy | Stunts |
| Byron Brisco | Stunts |
| Mike Crestejo | Stunts |
| Duane Dickinson | Stunts |
| Mike Dobbin | Stunts |
| Cameron Hilts | Stunts |
| Chris Beach | Art Direction |
| Craig Humphries | Art Direction |
| Shannon Gottlieb | Set Decoration |
| Susan Lambie | Script Supervisor |
| Vincent Stander | Loader |
| David Husby | Production Sound Mixer |
| Juniper Watters | Cableman |
| Nevin Swain | Property Master |
| Kevin Cockell | Assistant Property Master |
| Bryan Sutton | Set Designer |
| Devin Gray | Set Designer |
| Andrew Lee McConnell | Set Designer |
| Benoit Waller | Set Designer |
| Ester Bovard | Assistant Set Decoration |
| Kelly McLeod | Set Decoration Buyer |
| Joseph T. Mastrolia | Costume Supervisor |
| Paula Plachy | Assistant Costume Designer |
| Jeffrey Fayle | Set Supervisor |
| Jennifer Grossman | Costume Coordinator |
| Christopher Mark Pinhey | Makeup Department Head |
| Dorothee Deichmann | Makeup Artist |
| Tina Roesler Kerwin | Makeup Artist |
| Debra Wiebe | Hair Department Head |
| Samantha A. Smith | Hairstylist |
| Anne Morgan | Hairstylist |
| Ethan van der Ryn | Supervising Sound Editor |
| Ethan van der Ryn | Sound Designer |
| Erik Aadahl | Supervising Sound Editor |
| Erik Aadahl | Sound Editor |
| Joseph Dickerson | First Assistant Editor |
| Steve Rhee | Visual Effects Editor |
| Linda Drake | Visual Effects Editor |
| Salvatore Valone | Assistant Editor |
| Thom Kyle | Assistant Editor |
| Alex Burdett | Special Effects Coordinator |
| Abraham Fraser | Location Manager |
| Michael J. LeGresley | Assistant Location Manager |
| Leslie Woo | Casting Associate |
| Sheriz Tambanillo | Casting Assistant |
| Corinne Clark | Location Casting |
| Jennifer Page | Location Casting |
| Andrea Brown | Background Casting Director |
| Kimberly Buckham | Production Coordinator |
| Eddy Santos | Second Second Assistant Director |
| Peter Wilke | "A" Camera Operator |
| Ian R. C. Levine | "B" Camera Operator |
| Tim Walston | Sound Designer |
| Pratik Chaudhari | Visual Effects |
| Eric Mancha | VFX Artist |
| Ryan Wing | VFX Artist |
| Hamid Shahsavari | VFX Artist |
| Lahiru Jay | VFX Artist |
| Dan Morrison | First Assistant "A" Camera |
| Spencer Ennis | Second Assistant "A" Camera |
| Mitch Bax | Digital Imaging Technician |
| David Tickell | Chief Lighting Technician |
| Justin Giles | Assistant Chief Lighting Technician |
| Randy A. Jablonka | Electrician |
| Zack Cole | Electrician |
| Damian Kliman | Electrician |
| Liam Gerrie | Electrician |
| Jesse Deacon | Electrician |
| Nicholas Dent | Dolly Grip |
| Drew David | Grip |
| Mike Dodd | Grip |
| Alan McIndoe | Grip |
| Wes Grycki | Grip |
| Tony Hyland | Rigging Grip |
| Ben Ferguson | Stunts |
| Reid Scott | Thanks |
| David Arnold | Second Assistant Director |
| Trevor Jones | Stunts |
| Jeff Sanca | Stunt Driver |
