 | Ralph Fiennes als Spider |
 | Miranda Richardson als Yvonne / Mrs. Cleg |
 | Gabriel Byrne als Bill Cleg |
 | Lynn Redgrave als Mrs. Wilkinson |
 | John Neville als Terrence |
 | Philip Craig als John |
 | Bradley Hall als Spider Boy |
 | Gary Reineke als Freddy |
 | Sara Stockbridge als Gladys |
 | Cliff Saunders als Bob |
 | Tara Ellis als Nora |
 | Arthur Whybrow als Ernie |
 | Nicola Duffett als Barmaid |
 | Jake Nightingale als Large Man |
| Donald Ewer als Toothless Jack |
 | Joan Heney als Cook |
| Peter Elliott als Resident |
| Alec Stockwell als Resident |
 | Scott McCord als Resident |
| Rachel Taggart als Young Woman |
| Catherine Bailey | Producer |
| Simon Franks | Executive Producer |
| Jane Barclay | Executive Producer |
| Charles Finch | Executive Producer |
| Samuel Hadida | Producer |
| Howard Shore | Original Music Composer |
| David Cronenberg | Producer |
| David Cronenberg | Director |
| Peter Suschitzky | Director of Photography |
| Ronald Sanders | Editor |
| Patrick McGrath | Writer |
| Sharon Harel-Cohen | Executive Producer |
| Victor Hadida | Executive Producer |
| Sanjay Burman | Associate Producer |
| Clive Thomasson | Set Decoration |
| Maria Aitken | Associate Producer |
| Patrick McGrath | Novel |
| Andrew Sanders | Production Design |
| Guy Tannahill | Line Producer |
| Arvinder Greywal | Art Direction |
| Marina Morris | Set Decoration |
| Sara Giles | Associate Producer |
| Zygi Kamasa | Executive Producer |
| Martin Katz | Executive Producer |
| Hannah Leader | Executive Producer |
| Luc Roeg | Executive Producer |
| Denise Cronenberg | Costume Design |
| Lucy Richardson | Art Direction |
| Suzanne Smith | Casting |
| Paul Jefferson | Carpenter |
| Bryce Johnston | Carpenter |
| Joe Curtin | Construction Coordinator |
| Blanche McDermaid | Script Supervisor |
| Mary-Lou Green-Benvenuti | Hair Designer |
| Daniel White | Special Effects Coordinator |
| Stephan Dupuis | Makeup Artist |
| Brenda Gilles | Costume Supervisor |
| Hugh McKenzie | Carpenter |
| Vanessa Woolgar | Set Costumer |
| Nigel Egerton | Assistant Costume Designer |
| Sara Desmond | Second Assistant Director |
| Christine Allsopp | Makeup Artist |
| Inge Klaudi | Makeup Artist |
| Andrea Finch | Makeup Artist |
| Andrea Finch | Hairstylist |
| Tony Lilley | Hairstylist |
| Carol Marinoff | Assistant Hairstylist |
| Kelly Howard-Garde | Production Manager |
| Christian T. Cooke | Sound Re-Recording Mixer |
| Tony Currie | Sound Editor |
| David Evans | Supervising Sound Editor |
| Glen Gauthier | Production Sound Mixer |
| Robert Farr | ADR Mixer |
| Robert Farr | ADR Recordist |
| Wayne Griffin | Supervising Sound Editor |
| John Midgley | Sound Mixer |
| Orest Sushko | Sound Re-Recording Mixer |
| Goro Koyama | Foley Artist |
| Andy Malcolm | Foley Artist |
| Ron Mellegers | Foley Mixer |
| Cornelia Mariana Gavrilescu | Foley Recordist |
| Steve Switzer | Boom Operator |
| Don White | Foley Recordist |
| Alan Senior | Special Effects Supervisor |
| Stanley Monahan | Visual Effects |
