 | Tom Holland als Peter Parker / Spider-Man |
 | Samuel L. Jackson als Nick Fury |
 | Jake Gyllenhaal als Quentin Beck / Mysterio |
 | Marisa Tomei als May Parker |
 | Jon Favreau als Harold 'Happy' Hogan |
 | Zendaya als Michelle 'MJ' Jones |
 | Jacob Batalon als Ned Leeds |
 | Tony Revolori als Eugene 'Flash' Thompson |
 | Angourie Rice als Betty Brant |
 | Remy Hii als Brad Davis |
 | Martin Starr als Mr. Harrington |
 | J.B. Smoove als Mr. Dell |
 | Jorge Lendeborg Jr. als Jason Ionello |
 | Cobie Smulders als Maria Hill |
 | Numan Acar als Dimitri |
 | Zach Barack als Zach |
 | Zoha Rahman als Zoha |
 | Yasmin Mwanza als Yasmin |
 | Joshua Sinclair-Evans als Josh Spinelli |
 | Tyler Luke Cunningham als Tyler |
 | Sebastián Viveros als Sebastian |
 | Toni Garrn als The Seamstress |
 | Peter Billingsley als William Ginter Riva |
 | Clare Dunne als Victoria |
 | Nicholas Gleaves als Guterman |
 | Claire Rushbrook als Janice |
 | J.K. Simmons als J. Jonah Jameson |
 | Dawn Michelle King als E.D.I.T.H. (voice) |
 | Jeroen van Koningsbrugge als Dutch Soccer Hooligan 1 |
 | Michael de Roos als Dutch Soccer Hooligan 2 |
 | Jan-Paul Buijs als Dutch Soccer Hooligan 3 |
 | Sergio Pierattini als Venetian Glassblower |
 | Anjana Vasan als Queens Reporter |
 | Brian Law als Queens Reporter |
 | Evelyn Mok als Queens Reporter |
 | Tatiana Lunardon als Italian TV Newsreader |
 | Giada Benedetti als Italian Customs Office |
 | Lukáš Bech als Helpful Dutch Man |
 | Alessandro Giuggioli als Italian Street Vendor |
| Petr Opava als Opera Singer |
| Giuseppe Andriolo als Caricaturist |
 | Pat Kiernan als Pat Kiernan |
 | Shari Abdul als High School Reporter (uncredited) |
 | Mari Alexandrova als Tourist in Venice (uncredited) |
 | Kristen Alminta als Police Officer (uncredited) |
 | Vincent Angel als Midtown High Student (uncredited) |
 | Peter Arpesella als Airplane Pilot (uncredited) |
 | Lasco Atkins als Salvation Army guest (uncredited) |
 | Sitara Attaie als Dutch Lady (uncredited) |
 | Peter Bankolé als Mob Boss (uncredited) |
 | Blair Barnette als Queens Reporter (uncredited) |
 | Tuwaine Barrett als Officer Bristow (extended cut) |
 | Anna Benamati als Shop Owner in Venice (uncredited) |
 | Avondre E.D. Beverley als High School Student (uncredited) |
 | Bruno Bilotta als Mob Boss (uncredited) |
 | Sharon Blynn als Soren (uncredited) |
| Luigi Boccanfuso als Italian Builder in Venice (uncredited) |
| Paolo Braghetto als Poliziotto (uncredited) |
 | Dante Brattelli als High School Student (uncredited) |
 | Jeff Bridges als Obadiah Stane (archive footage) (uncredited) |
| Graham Burton als London Passerby (uncredited) |
| Ken Byrd als Post Office Customer (uncredited) |
 | Sokol Cahani als Mob Boss (uncredited) |
 | Darren Lee Campbell als Victoria's Crew (uncredited) |
 | Hélène Cardona als Austrian Backpacker (uncredited) |
 | Dian Cathal als American Reporter (uncredited) |
 | Jake Cerny als Airport Traveler (uncredited) |
 | Daphne Cheung als Passport Clerk (uncredited) |
| Sam Chuck als High School Student (uncredited) |
| Victoria Coburn als Passerby (uncredited) |
 | Kimberly Collison als Charity Event Mom (uncredited) |
| Tiziana Coste als Local Venetian (uncredited) |
 | Jaylen Davis als Tourist (uncredited) |
| Kristianne-Kaith Domingo als Passerby (uncredited) |
| Andrew Dunkelberger als Courier (uncredited) |
 | Charlie Esquér als Mexican Survivor (uncredited) |
 | Ria Fend als Tourist in Venice (uncredited) |
| Ferroz Fernandez als Tourist in Venice (uncredited) |
 | Vincent Frattini als Venice Local (uncredited) |
 | Massi Furlan als Flight Attendant (uncredited) |
| Cynthia Garbutt als Charity Dinner Guest (uncredited) |
| Thomas Goodridge als Tourist in Venice (uncredited) |
 | Sonia Goswami als Tourist (uncredited) |
| Nicholle Hembra als Saved Londoner (uncredited) |
 | Michael Hennessy als Hotel Guest (uncredited) |
 | Meagan Holder als Pretty Tourist (uncredited) |
 | Patrick Doran als Partygoer (uncredited) |
 | Ruth Clarson als Tourist (uncredited) |
| Chris Hyacinthe als Sneezy Tour Guide (uncredited) |
 | Michael Iacono als Airport Kid Traveler (uncredited) |
| Roman Ibragimov als Bar Customer (uncredited) |
 | Theo Ip als Tourist (uncredited) |
| Timothy Christian Jansen als High School Student (uncredited) |
| Keon Kendrick als Flight Attendant (uncredited) |
| Camille Kinloch als Midtown High School Student (uncredited) |
 | Michal Kubal als Czech TV News Anchor (uncredited) |
 | Hannah Kurczeski als Student (uncredited) |
 | Géraldine Lamarre als Traffic Warden (uncredited) |
 | Jimena Larraguivel als Mexican Villager (uncredited) |
 | Rich Lawton als Journalist (uncredited) |
 | Kat Leroy als Czech Traditional Dancer (uncredited) |
 | Gavin Lee Lewis als Londoner (uncredited) |
 | Patrick Loh als Airport Passenger (uncredited) |
 | Joseph Long als Mob Boss (uncredited) |
 | Marian Lorencik als New Czech Reveler (uncredited) |
 | Ketan Majmudar als Berlin Commuter (uncredited) |
 | Tony Mardon als Londoner (uncredited) |
 | Antonín Mašek als Bellboy (uncredited) |
 | Ben Mendelsohn als Talos (uncredited) |
 | Bradley Wj Miller als Passerby (uncredited) |
 | Melissa Beth Miller als Tourist (uncredited) |
 | Anthony Molinari als Mob Guy (uncredited) |
 | Adrian Mozzi als Venice Local (uncredited) |
 | Brendan Murphy als Police Officer (uncredited) |
| Amanda Musso als Carnival Hot Girl (uncredited) |
 | Emily Ng als Italian Tourist (uncredited) |
 | Daniel Olson als Czech Guy (uncredited) |
 | Hiten Patel als British Station Staff (uncredited) |
 | Luigi Petrazzuolo als Gondolier (uncredited) |
 | Aleksandrs Petukhovs als London Passerby (uncredited) |
 | Annie Pisapia als Traveler (uncredited) |
 | Jivan Xander Ramesh als Pedestrian (uncredited) |
| Mike Ray als Passerby (uncredited) |
 | Sofia Renee als High School Student (uncredited) |
 | Cailan Robinson als Victoria's Crew (uncredited) |
 | Emmanuel Rodriguez als Airport Traveler (uncredited) |
 | Ray Rosario als TSA Agent (uncredited) |
 | Daniel Ryves als Dad Collecting Kids (uncredited) |
 | Maurice Sardison als Party Goer (uncredited) |
| Karen-J Sear als American Tourist (uncredited) |
 | Ilya Tank Shilov als Venice Tourist (uncredited) |
 | Davina Sitaram als London Tourist (uncredited) |
 | Joakim Skarli als London Tourist (uncredited) |
| Lucas Antoine Starrets als Tourist (uncredited) |
 | Faith Tarby als Perfumed Lady (uncredited) |
 | Emily Tebbutt als Venice Tourist (uncredited) |
| Lesdy Vanessa als Tourist (uncredited) |
 | Jessica VanOss als Student (uncredited) |
 | Joe David Walters als Pawn Shop Owner (uncredited) |
| Jo Wheatley als Armed Security Officer (uncredited) |
 | Rocco Wu als Peter's Art Classmate (uncredited) |
| Samantha Mishinski als Student (uncredited) |
 | Aristou Meehan als Italian Boy (uncredited) |
 | Eric Patrick Cameron als Midtown High Student (uncredited) |
| Stan Lee | Comic Book |
| Jon Watts | Director |
| Steve Ditko | Comic Book |
| Chris McKenna | Writer |
| Erik Sommers | Screenplay |
| Leigh Folsom Boyd | Editor |
| Dan Lebental | Editor |
| Kevin Feige | Producer |
| Amy Pascal | Producer |
| Eric Hauserman Carroll | Executive Producer |
| David Minkowski | Co-Producer |
| Avi Arad | Executive Producer |
| Thomas M. Hammel | Executive Producer |
| Matthew Stillman | Co-Producer |
| Stan Lee | Executive Producer |
| Matt Tolmach | Executive Producer |
| Louis D'Esposito | Executive Producer |
| Victoria Alonso | Executive Producer |
| Adrian Rigby | Makeup Artist |
| Madlen Mierzwiak | Makeup & Hair |
| Rachael Speke | Makeup Artist |
| Daniel McGraw | Makeup Artist |
| Rachel Lennon | Makeup Artist |
| Livia Borgognoni | Art Direction |
| Gary Jopling | Art Direction |
| Grant Armstrong | Supervising Art Director |
| Tamsin Dorling | Makeup & Hair |
| Nigel Evans | Art Direction |
| Nicola Pope | Makeup Artist |
| Donald Mowat | Makeup Artist |
| Claude Paré | Production Design |
| Matthew Kerly | Art Direction |
| Tina Jones | Set Decoration |
| Jiri Matura | Art Direction |
| Roseanna Larner | Makeup & Hair |
| Jake Garber | Makeup Artist |
| Renate Nicolaisen | Art Direction |
| Anna B. Sheppard | Costume Design |
| James Lewis | Art Direction |
| Jann K. Engel | Supervising Art Director |
| Charley Beal | Art Direction |
| Vasilios Tanis | Makeup Artist |
| Joe Howard | Art Direction |
| Mike Lutz | Set Costumer |
| Jörn Großhans | Visual Effects Supervisor |
| Janek Sirrs | Visual Effects Supervisor |
| Theodore Bialek | Visual Effects Supervisor |
| Oliver Benson | Assistant Art Director |
| Iain Mackay | Camera Operator |
| Gary Nagle | Lighting Technician |
| Brian McCafferty | Rigging Grip |
| Blair Aycock | Key Makeup Artist |
| Eddie Flores | Key Grip |
| Stefano Marino | Gaffer |
| JoJo Whilden | Still Photographer |
| Janine Rath-Thompson | Hair Department Head |
| Xavier Guillen | Drone Cinematographer |
| Dani Rose | Drone Pilot |
| Jonathan Spencer | Gaffer |
| Ricky Loncaric | Key Grip |
| Rodrigo Gutierrez | Camera Operator |
| Michael Gallart | Rigging Gaffer |
| Tommaso Mele | Key Grip |
| Jeremy Braben | Aerial Director of Photography |
| Quinn McMillan | Camera Operator |
| Alan Perrin | Drone Pilot |
| Joshua Dempsey | Lighting Technician |
| James Nesbitt | Lighting Technician |
| Heba Thorisdottir | Makeup Department Head |
| Alfonso Lujan Jr. | Key Grip |
| Kevin Baker | Still Photographer |
| Matthew J. Lloyd | Director of Photography |
| Matiki Anoff | Makeup Department Head |
| Annabelle Nutt | Gaffer |
| Simon Muir | Key Grip |
| Norina Mackey | Script Supervisor |
| Deirdre Horgan | Script Supervisor |
| Hanoi De La Paz | Rigging Gaffer |
| Andy Thomson | Russian Arm Operator |
| Jo Beckett | Script Supervisor |
| Paula Price | Key Hair Stylist |
| Seana Gorlick | Key Makeup Artist |
| Shaun Cobley | Steadicam Operator |
| Pete Cavaciuti | Steadicam Operator |
| Holly Johnson | Script Supervisor |
| Michelle Johnson | Hair Department Head |
| Layna Roberts | Key Hair Stylist |
| Gabriela Poláková | Key Makeup Artist |
| Robert Stile | Key Grip |
| Robert B. Dechellis | Rigging Gaffer |
| Daniel Aranyó | Second Unit Director of Photography |
| Jonathan Beattie | Steadicam Operator |
| Petr Stuna | Still Photographer |
| Linda Eisenhamerová | Key Hair Stylist |
| Mark Mitchell | Camera Operator |
| James McMillan | Second Unit Cinematographer |
| Adam Sculthorp | Aerial Camera |
| Andrea Arnone | Camera Operator |
| Sean Ricigliano | Epk Camera Operator |
| Alan Martin | Gaffer |
| Jason Martin | Rigging Gaffer |
| Richard Philpott | Camera Operator |
| Brad Goss | Key Grip |
| Peter Paul | Assistant Costume Designer |
| Nicola Belton | Textile Artist |
| Anna Maria Genuise | Wardrobe Supervisor |
| Olivia Brittain | Casting Associate |
| Jane Gooday | Assistant Costume Designer |
| Nina Jagersbacher | Assistant Costume Designer |
| Dagmar Pomajbikova | Costume Supervisor |
| Stacey Clare Richards | Key Costumer |
| Eilish Zebrasky | Assistant Costume Designer |
| Birgitta Fredlund | Costume Coordinator |
| Shannon Avalos | Extras Casting |
| Moira Shaughnessy | Wardrobe Supervisor |
| Georgia Fleury Reynolds | Casting Assistant |
| Jason B. Stamey | Casting Associate |
| Eliza Heslop | Casting Assistant |
| Molly Doyle | Casting Assistant |
| Jonathan Richards | Set Costumer |
| Meghan Corea | Assistant Costume Designer |
| Daryl Bristow | Costume Supervisor |
| Jacqueline Mulligan | Seamstress |
| Brad Bittner | Extras Casting |
| Jirí Hrstka | Extras Casting |
| Sarah Halley Finn | Casting |
| Darrell Warner | Costume Illustrator |
| Lisa D. Quercioli | Costumer |
| Anthony Drewett | Costumer |
| Askia Won-Ling Jacob | Costumer |
| Max Brennan | Key Costumer |
| Marina Ray | Assistant Costume Designer |
| Helen Felstead | Key Costumer |
| Barbara Sweryda | Key Costumer |
| Michaela Dejmalova | Costumer |
| Kaniez Braganza | Textile Artist |
| Steven Ticknor | Sound Designer |
| Paul E. Miller | Boom Operator |
| Alec Rubay | Foley Supervisor |
| Chris Munro | Production Sound Mixer |
| Ken McGill | Sound Effects Editor |
| Colin H. Fraser | Construction Manager |
| Michael Miller | ADR Mixer |
| Chris Diebold | Sound Designer |
| Casey Genton | Sound Effects Editor |
| Tony Lamberti | Supervising Sound Editor |
| Xuria Cristobal | Art Department Coordinator |
| James Eubank | Property Master |
| Robert Broadfoot | Set Designer |
| James Morioka | Dialogue Editor |
| Rick Owens | Foley Artist |
| Kevin O'Connell | Sound Re-Recording Mixer |
| Cindy M. Ichikawa | Art Department Coordinator |
| Anthony Carlino | Leadman |
| Steven Ticknor | Supervising Sound Editor |
| Karl J. Martin | Set Designer |
| Gabriel Sanders | Boom Operator |
| Kyle Rochlin | Foley Mixer |
| Lee Orloff | Sound Mixer |
| Petr Mazura | Leadman |
| Bárbara Pérez-Solero | Art Direction |
| Hunter Berk | ADR Mixer |
| Katherine Pearl | Art Department Coordinator |
| Katerina van Gemundova | Art Department Coordinator |
| Martin Švojger | Boom Operator |
| Sean Byrnes | Production Sound Mixer |
| Lisa Williams | Graphic Designer |
| Karen Vassar Triest | Sound Editor |
| Andrew Sissons | Sound Mixer |
| Nick Roberts | ADR Mixer |
| Julian Townsend | Production Sound Mixer |
| Daniel Boxer | Property Master |
| Graeme Purdy | Property Master |
| Dan Kenyon | Sound Effects Editor |
| Mimi Violette | Graphic Designer |
| Jim Hewitt | Set Designer |
| Dicken Berglund | ADR Mixer |
| Milos Stojanovic | ADR Mixer |
| Petr Čechák | Production Sound Mixer |
| Rodrigo Busto | Property Master |
| Tony Lamberti | Sound Re-Recording Mixer |
| Mario De Socio | ADR Recordist |
| Andy Sisul | Sound Designer |
| Lloyd Dudley | Sound Mixer |
| Mirko von Berner | Swing |
| Harrison Osterfield | Actor's Assistant |
| Larkin Seiple | Additional Photography |
| Jerad Marantz | Concept Artist |
| Rachel O'Connor | Executive Producer |
| Anna Sweeney | Assistant Editor |
| Jared Hasselbach | VFX Artist |
| Florian Boury | VFX Artist |
| Mark LeDoux | Visual Effects Supervisor |
| Brad Lucas | Digital Compositor |
| Andy Martinez Calzadilla | Visual Effects |
| Aldo Martinez Calzadilla | Animation |
| Andrea Maxwell | Visual Effects Editor |
| Paul Song | Digital Compositor |
| Christian Wood | Digital Compositor |
| Ndosi Anyabwile | Digital Compositor |
| Jasper M. Baltzersen | Digital Compositor |
| John Brubaker | Compositing Supervisor |
| Daniel Dupre | Digital Compositor |
| Richard Fox | Digital Compositor |
| Daniel J. Pastor | Digital Compositor |
| Eric Timm | Compositing Artist |
| Douglas James Smith | Lighting Artist |
| Timothy Eulich | Stunt Double |
| Amy Johnston | Stunts |
| Michael Giacchino | Original Music Composer |
| Joe Watts | Stunts |
| Luci Romberg | Stunts |
| Kiante Elam | Stunt Double |
| Paola Altobelli | Stunts |
| Hayley Ainsley | Stunts |
| Nina Armstrong | Stunts |
| Georgina Armstrong | Stunts |
| Jan Brichcín | Stunts |
| Marek Brichcin | Stunts |
| Petr Bozdech | Stunts |
| Liam Carey | Stunts |
| Kevin Cassidy | Stunts |
| Matous Brichcin | Stunts |
| Brona Chaloupkova | Stunts |
| Massimiliano Catasta | Stunts |
| Jonathan Cohen | Stunts |
| George Cottle | Stunt Coordinator |
| Liam Coote | Stunts |
| Giampiero Comanducci | Stunts |
| James Cox | Stunt Double |
| Brycen Counts | Stunts |
| Jason Curle | Stunts |
| Lucky Davis | Stunts |
| Andrius Davidenas | Stunts |
| Jim Dowdall | Stunts |
| Federica Della Martira | Stunts |
| Zuzana Drdacka | Stunts |
| Hana Dvorská | Stunts |
| Michaela Dvorska | Stunts |
| Martin Engel | Stunts |
| Danny Euston | Stunts |
| James Embree | Stunts |
| Josie Forman | Stunts |
| Bradley Farmer | Stunts |
| Rocco Maria Franco | Stunts |
| Sarah Franzl | Stunts |
| Martin Gordon | Stunts |
| Maria Gnecchi | Stunts |
| Dan Griffiths | Stunts |
| David R. Grant | Stunts |
| Madeleine Hance | Stunt Coordinator |
| Romana Hájková | Stunts |
| Gabriella Harman | Stunts |
| James Harris | Stunts |
| Nadia Hansell | Stunts |
| Maria Hippolyte | Stunts |
| Paul Heasman | Stunts |
| Jacob Hugghins | Stunts |
| Rachel Holifield | Stunts |
| Jiří Horký | Stunts |
| Gary Kane | Stunts |
| Marek Jelinek | Stunts |
| Ellie Keighley | Stunts |
| Akouala Cristel Julien | Stunts |
| Jiří Kraus | Stunts |
| Keone Kim | Stunts |
| Pavel Krátký | Stunts |
| Maurice Lee | Stunts |
| Petr Kučera | Stunts |
| Sarah Lochlan | Stunts |
| Carly Michaels | Stunts |
| David Matoušek | Stunts |
| Chelsea Mather | Stunts |
| Theo Morton | Stunts |
| William Morts | Stunts |
| Riccardo Mioni | Stunt Coordinator |
| David Newton | Stunts |
| Daniele Nguyen | Stunts |
| James Mitchell-Clyde | Stunts |
| Jake Osborn | Stunts |
| Vaclav Pacal | Stunts |
| Wilson Peres | Stunts |
| Catherine Peck | Stunts |
| Jaroslav Peterka | Stunts |
| Monika Podzimkova | Stunts |
| Marta Pinna | Stunts |
| Tomáš Peteráč | Stunts |
| Douglas Robson | Stunts |
| Chris Pollard | Stunts |
| Emanuele Romano | Stunts |
| Valentina Rossi Stuart | Stunts |
| Federico Regazzo | Stunts |
| Tomas Rydval | Stunts |
| Luke Scott | Stunt Double |
| Petr Sekanina | Stunts |
| Marek Simbersky | Stunts |
| Michaela Salamounova | Stunts |
| Venice Smith | Stunts |
| Martin Spur | Stunts |
| Adam Smith | Stunts |
| Frantisek Stupka | Stunts |
| Mark Stanton-Kelly | Stunts |
| Laura Swift | Stunts |
| Tamara Tassi | Stunts |
| Marie Švecová | Stunts |
| Karen Teoh | Stunts |
| Greg Townley | Stunt Double |
| Rocky Taylor | Stunts |
| Vittorio Verdirosi | Stunts |
| Miroslav Valka | Stunts |
| Jan Vosmik | Stunts |
| Aaron Vexler | Stunts |
| Marlow Warrington-Mattei | Fight Choreographer |
| Jiří Vostrovský | Stunts |
| Eddie Yansick | Stunts |
| Annabel Wood | Stunts |
| Chris Barnes | Stunts |
| Gavin Barnes | Stunts |
| Elizabeth Donker Curtius | Stunts |
| Stephanie Carey | Stunt Driver |
| Aja Frary | Stunt Double |
| Luke Gomes | Stunt Double |
| Ingrid Kleinig | Stunts |
| Jess King | Stunts |
| Jade Quon | Stunts |
| Tilly Powell | Stunts |
| Tony Lazzara | Stunts |
| Tracey Ruggiero | Utility Stunts |
| Riley Flanagan | Second Assistant Director |
| Hiroshi Mori | Visual Effects |
| Jack Kirby | Comic Book |
| Joe Simon | Comic Book |
| Todd Harris | Storyboard Artist |
