 | Adrien Brody als Clive |
 | Sarah Polley als Elsa |
 | Delphine Chanéac als Dren |
 | David Hewlett als Barlow |
 | Abigail Chu als Young Dren |
 | Stephanie Baird als Elsa / PD |
 | Brandon McGibbon als Gavin |
 | Amanda Brugel als Melinda Finch |
| Simona Măicănescu als Joan Chorot |
| Guillermo del Toro | Producer |
| Steven Hoban | Producer |
| Antoinette Terry Bryant | Screenplay |
| Vincenzo Natali | Screenplay |
| John Buchan | Casting |
| Todd Cherniawsky | Production Design |
| Constance Demontoy | Casting |
| Joshu de Cartier | Art Direction |
| Doug Taylor | Screenplay |
| Jason Knight | Casting |
| Alex Kavanagh | Costume Design |
| Marie Nardella | Makeup Department Head |
| Vincenzo Natali | Director |
| David McCallum | Supervising Sound Editor |
| Roderick Deogrades | Sound Effects Editor |
| Rossana DeCampo | Scenic Artist |
| Garrett Kerr | Sound Effects Editor |
| Stefan Fraticelli | Foley |
| Lisa Burling | Script Supervisor |
| Sam Hudecki | Assistant Art Director |
| Alain Lalanne | Visual Effects Producer |
| David Sanger | Visual Effects Producer |
| Bob Munroe | Visual Effects Supervisor |
| Fabrice Lagayette | Visual Effects Supervisor |
| Chris Howard | Gaffer |
| Jason Lunn | Leadman |
| Laurent Kossayan | Supervising Sound Editor |
| Daniel White | Special Effects Coordinator |
| Jean-François Bourrel | Visual Effects Producer |
| Dale Gagne | Visual Effects Producer |
| David Rose | Sound Designer |
| Jacques Bled | Visual Effects Producer |
| Pierre Buffin | Visual Effects Supervisor |
| Angelo Colavecchia | Camera Operator |
| Chris Howard | Thanks |
| Aidan Stanford | Color Timer |
| Steve Wilkie | Still Photographer |
| Shie Rozow | Music Editor |
| David R. Beecroft | Hairstylist |
| John Sievert | Foley |
| Michael Griffith | Visual Effects Editor |
| Christopher M. Meagher | Digital Intermediate |
| François-Xavier Aubague | Visual Effects Producer |
| Arnauld Boulard | Visual Effects Producer |
| Steve Pederson | Sound Re-Recording Mixer |
| Ian Hunter | Visual Effects Supervisor |
| Plato Fountidakis | Stunt Coordinator |
| Dino Laurenza | Camera Operator |
| William Cheng | Set Designer |
| Brad Sherman | Sound Re-Recording Mixer |
| Marty Dejczak | Location Manager |
| Joseph Boccia | Production Manager |
| Mark Shnuriwsky | Sound Effects Editor |
| Paul Rapovski | Stunt Coordinator |
| Leslie Kavanagh | Costume Supervisor |
| Sue Len Quon | Visual Effects Editor |
| Dana Howes | Transportation Coordinator |
| Christina Butterfield | VFX Artist |
| Cyrille Aufort | Original Music Composer |
| Vincenzo Natali | Story |
| Michele Conroy | Editor |
| Jill Purdy | Dialogue Editor |
| Tetsuo Nagata | Director of Photography |
| Janice Ierulli | Dialogue Editor |
| Lou Thomas | Dialogue Editor |
| Antoinette Terry Bryant | Story |
| James R. Murray | Property Master |
| Jean-Alexandre Villemer | Sound Recordist |
| Cynthia Amsden | Unit Publicist |
| Franck Chorot | Producer |
| Mark Manchester | Key Grip |
| Sarah Campbell | Second Assistant Director |
| John Colavecchia | First Assistant "B" Camera |
| David Herrington | Second Unit Director of Photography |
| Hubert Boorder | Stunt Double |
| Jeff DaSilva | Second Assistant Camera |
| Amanda Wojtaszek | Camera Loader |
| Desiree Lidon | Electrician |
| Mario Moreira | Assistant Property Master |
| Mark Cyre | First Assistant "A" Camera |
| Christopher Cordell | Stunt Double |
| Bob Munroe | Second Unit Director |
| Andrew Shea | First Assistant Director |
| Marc Kuitenbrouwer | Construction Coordinator |
| Julia Valente | Assistant Makeup Artist |
| Lydia Pensa | Assistant Hairstylist |
| Jane Conway | Animal Wrangler |
| Steve Copley | Foley Recordist |
| Michel Monier | Dolby Consultant |
| Brandon Prodger | ADR Recordist |
| Chris Wallace | Digital Intermediate Colorist |
| Peter Armstrong | Digital Intermediate Producer |
