 | William Shatner als Admiral James T. Kirk |
 | DeForest Kelley als Dr. Leonard 'Bones' McCoy |
 | James Doohan als Captain Montgomery 'Scotty' Scott |
 | George Takei als Cmdr. Hikaru Sulu |
 | Walter Koenig als Cmdr. Pavel Chekov |
 | Nichelle Nichols als Cmdr. Uhura |
 | Christopher Lloyd als Cmdr. Kruge |
 | Robin Curtis als Lt. Saavik |
 | Mark Lenard als Ambassador Sarek |
 | Merritt Butrick als Dr. David Marcus |
 | Judith Anderson als Vulcan High Priestess |
 | James B. Sikking als Captain Styles |
 | Phillip R. Allen als Capt. Esteban |
 | Robert Hooks als Admiral Morrow |
 | John Larroquette als Maltz |
 | Carl Steven als Spock...Age 9 |
 | Vadia Potenza als Spock...Age 13 |
 | Stephen Manley als Spock...Age 17 |
| Joe W. Davis als Spock at age 25 |
 | Leonard Nimoy als Captain Spock / Elevator Voice |
 | Miguel Ferrer als First Officer |
 | Branscombe Richmond als Klingon Gunner #2 |
 | Frank Welker als Spock's Screams |
 | Scott McGinnis als Starfleet Cadet "Mr. Adventure" |
 | Phil Morris als Trainee Foster |
 | Jeanne Mori als Helm Officer |
 | Grace Lee Whitney als Commander Janice Rand (Woman in Cafeteria) |
| Nanci Rogers als Bar Waitress (uncredited) |
| Paul Sorensen als Captain |
| Tom Pedigo | Set Decoration |
| Leonard Nimoy | Director |
| Elza Bergeron | Casting |
| James Horner | Original Music Composer |
| Mary Ann Barton | Casting |
| Stuart Jensen | Casting |
| John E. Chilberg II | Art Direction |
| Harve Bennett | Producer |
| Charles Correll | Director of Photography |
| Robert Fletcher | Costume Design |
| Robert F. Shugrue | Editor |
| Ken Ralston | Visual Effects Supervisor |
| Harve Bennett | Writer |
| Gary Nardino | Executive Producer |
| Ralph Winter | Associate Producer |
| Wes Dawn | Makeup Artist |
| Silvia Abascal | Hairstylist |
| Jim Kail | Makeup Artist |
| James Lee McCoy | Makeup Artist |
| Steve LaPorte | Special Effects Makeup Artist |
| Tom Woodruff Jr. | Special Effects Makeup Artist |
| Rick Stratton | Makeup Artist |
| John Hockridge | First Assistant Director |
| Cecelia Hall | Supervising Sound Editor |
| Robert W. Glass Jr. | Sound Re-Recording Mixer |
| Alan Howarth | Sound Effects |
| David J. Hudson | Sound Re-Recording Mixer |
| Ray West | Sound Re-Recording Mixer |
| Bob Dawson | Special Effects |
| R.A. Rondell | Stunt Coordinator |
| Al Jones | Stunt Double |
| John C. Meier | Stunt Double |
| Steve Blalock | Stunts |
| Phil Chong | Stunts |
| Eddy Donno | Stunts |
| David Burton | Stunts |
| Kenny Endoso | Stunts |
| Chuck Hicks | Stunts |
| James M. Halty | Stunts |
| Jeff Jensen | Stunts |
| Tom Morga | Stunts |
| Don Charles McGovern | Stunts |
| Alan Oliney | Stunts |
| Danny Rogers | Stunts |
| Chuck Picerni Jr. | Stunts |
| Ron Stein | Stunt Coordinator |
| Frank James Sparks | Stunts |
| Ernest Robinson | Stunts |
| Jean Coulter | Stunts |
