 | Chris Pine als Captain James T. Kirk |
 | Zachary Quinto als Commander Spock |
 | Zoe Saldaña als Leuitenant Nyota Uhura |
 | Karl Urban als Dr. Leonard 'Bones' McCoy |
 | Simon Pegg als Lieutenant Commander Montgomery 'Scotty' Scott |
 | John Cho als Lieutenant Hikaru Sulu |
 | Benedict Cumberbatch als John Harrison / Khan |
 | Anton Yelchin als Ensign Pavel Chekov |
 | Bruce Greenwood als Admiral Christopher Pike |
 | Peter Weller als Admiral Alexander Marcus |
 | Alice Eve als Dr. Carol Marcus |
 | Leonard Nimoy als Ambassador Spock |
 | Noel Clarke als Thomas Harewood |
 | Nazneen Contractor als Rima Harewood |
 | Amanda Foreman als Ensign Brackett |
 | Jay Scully als Lieutenant Chapin |
 | Jonathan Dixon als Ensign Froman |
 | Aisha Hinds als Navigation Officer Darwin |
 | Joseph Gatt als Science Officer 0718 |
 | Jeremy Raymond als Lead Nibiran |
 | Tony Guma als Nibiran |
 | Kimberly Arland als Madeline |
 | Sean Blakemore als Klingon |
 | Nick E. Tarabay als Klingon |
 | Beau Billingslea als Captain Abbot |
 | Deep Roy als Keenser |
 | Anjini Taneja Azhar als Lucille Harewood |
 | Jack Laufer als Doctor |
 | Katie Cockrell als Girl |
 | Kellie Cockrell als Girl |
 | Jason Matthew Smith als Cupcake |
 | Seth Ayott als U.S.S. Enterprise Shuttle Ensign |
 | Marco Sanchez als Torpedo Security |
 | Lee Reherman als Uniformed Mercenary |
 | Scott Lawrence als U.S.S. Vengeance Officer |
 | Usman Ally als U.S.S. Vengeance Officer |
 | Nolan North als U.S.S. Vengeance Bridge Officer |
 | James Hiroyuki Liao als U.S.S. Vengeance Bridge Officer |
 | Rob Moran als U.S.S. Vengeance Ensign |
 | Berit Francis als Starfleet Admiral |
 | Akiva Goldsman als Starfleet Admiral |
| Benjamin P. Binswanger als Starfleet Admiral |
 | Christopher Doohan als Transport Officer |
| Andy Demetrio als U.S.S. Enterprise Bridge Crew |
 | Gianna Simone als U.S.S. Enterprise Bridge Crew |
 | Rene Rosado als U.S.S. Enterprise Bridge Crew |
 | Jacqueline King als U.S.S. Enterprise Bridge Crew |
| Long Tran als U.S.S. Enterprise Bridge Crew |
| Ningning Deng als U.S.S. Enterprise Bridge Crew |
| Jodi Johnston als U.S.S. Enterprise Bridge Crew |
| Colleen Harris als Lady V |
 | Jeff Chase als U.S.S. Enterprise Security |
| Monisola Akiwowo als U.S.S. Enterprise Nurse |
 | Paul K. Daniel als Shuttle Pilot |
 | Ser'Darius Blain als U.S.S. Enterprise Red Shirt |
 | Heather Langenkamp als Moto |
| David C. Waite als U.S.S. Enterprise Crew |
 | Melissa Paulo als Bar Girl |
 | Cynthia Addai-Robinson als San Francisco Woman |
| Drew Grey als San Francisco Bar Patron |
| Douglas Weng als U.S.S. Vengeance Security |
| Charlie Haugk als San Francisco Resident |
| Max Chernov als San Francisco Resident |
| Marc Primiani als San Francisco Resident |
| Jesper Inglis als San Francisco Resident |
 | Jacob Rhodes als Nibiru Child |
| Kentucky Rhodes als Nibiru Child |
| Anthony Wilson als Shaku |
| Eric Greitens als Starfleet Ceremonial Guard |
| Melissa Steinman als Starfleet Ceremonial Guard |
| Adam McCann als Starfleet Ceremonial Guard |
| Jon Orvasky als Starfleet Ceremonial Guard |
 | Gerald W. Abrams als Starfleet Memorial Admiral |
| James McGrath als Starfleet Memorial Admiral |
 | Brian T. Delaney als Additional Voices (voice) |
 | Arlen Escarpeta als Additional Voices (voice) |
 | Joe Moses als Additional Voices (voice) |
 | Kevin Michael Richardson als Additional Voices (voice) |
 | David Sobolov als Additional Voices (voice) |
 | Matthew Wood als Additional Voices (voice) |
 | Fred Tatasciore als Additional Voices (voice) |
 | Kiff VandenHeuvel als Additional Voices (voice) |
 | Audrey Wasilewski als Additional Voices (voice) |
 | Bill Hader als Additional Voices (voice) |
 | Britanni Johnson als NYU Nurse (uncredited) |
 | Chris Gardner als Additional Voices (voice) |
 | Julianne Buescher als Additional Voices (voice) |
 | Joe Hanna als Additional Voices (voice) |
 | David Acord als Additional Voices (voice) |
 | Elle Newlands als Additional Voices (voice) |
 | Candice Renee als Additional Voices (voice) |
| Emily Towers als Additional Voices (voice) |
| Gina Hirsch als Additional Voices (voice) |
 | Tom Archdeacon als Ensign Spyke (uncredited) |
 | Jon Lee Brody als U.S.S. Enterprise Security (uncredited) |
 | Hiram A. Murray als Bar Patron (uncredited) |
 | Fernando Chien als Starfleet Admiral (uncredited) |
| Scott Chambliss | Production Design |
| Roberto Orci | Producer |
| J.J. Abrams | Producer |
| Alex Kurtzman | Producer |
| Damon Lindelof | Producer |
| J.J. Abrams | Director |
| Bryan Burk | Producer |
| Michael Giacchino | Original Music Composer |
| Dana Goldberg | Executive Producer |
| Maryann Brandon | Editor |
| Paul Schwake | Executive Producer |
| David Ellison | Executive Producer |
| Mary Jo Markey | Editor |
| April Webster | Casting |
| Dan Mindel | Director of Photography |
| Jeffrey Chernov | Executive Producer |
| Alyssa Weisberg | Casting |
| Andrew Murdock | Art Direction |
| Karen Manthey | Set Decoration |
| Michael Kaplan | Costume Design |
| Kasra Farahani | Art Direction |
| Harry E. Otto | Art Direction |
| Lauren E. Polizzi | Art Direction |
| Michael E. Goldman | Art Direction |
| Jenn Emberly | Animation Supervisor |
| Ramiro Belgardt | Music Editor |
| Alex Levy | Music Editor |
| Brian N. Bentley | Compositors |
| Brian Avery | Stunts |
| Ramsey Avery | Supervising Art Director |
| Dawn Gilliam | Script Supervisor |
| Philippe Carr-Forster | Camera Operator |
| Stephen Christensen | Assistant Art Director |
| Burt Dalton | Special Effects Supervisor |
| Luke O'Byrne | Visual Effects Producer |
| Andy Nelson | Sound Re-Recording Mixer |
| Daniel Pearson | CG Supervisor |
| Dale Taylor | Visual Effects Producer |
| Jason M. Moore | Set Costumer |
| Jaimie Trueblood | Still Photographer |
| Natasha Gerasimova | Assistant Art Director |
| John Skotchdopole | Camera Operator |
| Paul Kavanagh | Animation Supervisor |
| Ron Ames | Visual Effects Producer |
| Dustin Cawood | Sound Effects Editor |
| Matthew Wood | Supervising Sound Editor |
| Myron Baker | Set Costumer |
| Brandon Fayette | Animation |
| Yanick Dusseault | Visual Effects Art Director |
| Lorelei David | Visual Effects Editor |
| Chris Snyder | Construction Coordinator |
| Malcolm Fife | Sound Effects Editor |
| Mary L. Mastro | Hair Department Head |
| Enrico Damm | CG Supervisor |
| Neville Page | Creature Design |
| Robert Weaver | CG Supervisor |
| Adam Watkins | Digital Effects Supervisor |
| Kevin Baillie | Visual Effects Supervisor |
| Karen Iverson | Makeup Artist |
| Alisa Simonds | Visual Effects Editor |
| Stuart McAra | Visual Effects Producer |
| Michele Payne | Hairstylist |
| Vera Steimberg | Makeup Artist |
| Christine Youngstrom | Art Department Coordinator |
| Colin Anderson | Camera Operator |
| Dale Myrand | Camera Operator |
| Ann Foley | Assistant Costume Designer |
| Ronni Brown | Foley |
| Erin Davis | Digital Intermediate |
| Julian Smirke | First Assistant Editor |
| Andrew Rowlands | Steadicam Operator |
| Anthony Almaraz | Set Costumer |
| Brian David Miller | Visual Effects Editor |
| Richard Ivan Mann | Visual Effects Producer |
| Don Rutherford | Makeup Artist |
| Berter Orpak | Animation |
| Ben Burtt | Sound Designer |
| David LeRoy Anderson | Makeup Department Head |
| Roger Guyett | Visual Effects Supervisor |
| Bastian Wartenberg | Animation |
| Rita DaSilva | First Assistant Editor |
| Florian Friedmann | Animation |
| Lisa A. Doyle | Set Costumer |
| Ben Grossmann | Visual Effects Supervisor |
| Sean England | Foley |
| Janine Rath-Thompson | Key Hair Stylist |
| Sebastian Butenberg | Animation Supervisor |
| James Clyne | Visual Effects Art Director |
| Jeanne Van Phue | Makeup Artist |
| Andy Kaplan | Digital Intermediate |
| Andrea Carter | Art Department Coordinator |
| James W. Tyson | Costume Supervisor |
| Pascal Garneau | Sound Effects Editor |
| Sheryl Blum | Hairstylist |
| Juan Ignacio Cabrera | Digital Intermediate |
| Randall D. Wilkins | Set Designer |
| Peter J. Devlin | Sound Mixer |
| Steve Slanec | Dialogue Editor |
| Stuart McCowan | ADR Editor |
| Bruce McCleery | Second Unit Director of Photography |
| Ryan Cole | Sound Recordist |
| Andrew M. Siegel | Property Master |
| Cheryl Nardi | Dialogue Editor |
| Danielle Dupre | Sound Recordist |
| Sala Baker | Stunts |
| Patrick Tubach | Visual Effects Supervisor |
| Andrea Datzman | Music Coordinator |
| Ian Calip | Second Assistant Director |
| Sean MacKenzie | Stereoscopic Supervisor |
| Veronica Lorenz | Special Effects Makeup Artist |
| Eugene Collier | Stunt Double |
| Jennifer Caputo | Stunts |
| Caryn Mower | Stunts |
| John McGonegle | Electrician |
| Deborah Rutherford | Assistant Makeup Artist |
| Jessica Harbeck | Stunts |
| Shauna Duggins | Stunts |
| Roberto Orci | Writer |
| Alex Kurtzman | Writer |
| Damon Lindelof | Writer |
| Gene Roddenberry | Original Series Creator |
| J.J. Perry | Stunts |
| Mark De Alessandro | Stunts |
| Doug Coleman | Stunts |
| Peewee Piemonte | Utility Stunts |
| Krista Bell | Stunts |
| Marie Fink | Stunt Double |
| Dane Farwell | Stunts |
| Cassandra McCormick | Stunt Double |
| Tanoai Reed | Stunts |
| Kurt D. Lott | Stunts |
