 | William Shatner als Captain James T. Kirk |
 | Leonard Nimoy als Captain Spock |
 | DeForest Kelley als Dr. Leonard 'Bones' McCoy |
 | James Doohan als Captain Montgomery 'Scotty' Scott |
 | George Takei als Cmdr. Hikaru Sulu |
 | Walter Koenig als Cmdr. Pavel Chekov |
 | Nichelle Nichols als Cmdr. Uhura |
 | Laurence Luckinbill als Sybok |
 | David Warner als St. John Talbot |
 | Charles Cooper als Gen. Korrd |
 | Cynthia Gouw als Caithlin Dar |
 | Todd Bryant als Capt. Klaa |
 | Spice Williams-Crosby als Vixis (as Spice Williams) |
 | Rex Holman als J'onn |
 | George Murdock als God |
| Jonathan Simpson als Young Sarek |
| Beverly Hart als High Priestess |
| Steve Susskind als Pitchman |
 | Harve Bennett als Starfleet Chief of Staff |
| Cynthia Blaise als Amanda |
| Bill Quinn als McCoy's Father |
 | Melanie Shatner als Yeoman |
 | Michael Berryman als Sybok Warrior (uncredited) |
 | Carey Scott als Young Spock |
| William Shatner | Director |
| Harve Bennett | Producer |
| David Loughery | Screenplay |
| Andrew Laszlo | Director of Photography |
| John M. Dwyer | Set Decoration |
| Jerry Goldsmith | Original Music Composer |
| Herman F. Zimmerman | Production Design |
| Bill Shepard | Casting |
| Peter E. Berger | Editor |
| Michael Wood | Special Effects Supervisor |
| Dick Ziker | Stunts |
| Mel Efros | Co-Producer |
| Mel Efros | Unit Production Manager |
| Mark A. Mangini | Sound Effects |
| Harve Bennett | Story |
| William Shatner | Story |
| David Loughery | Story |
| Ralph Winter | Executive Producer |
| Gene Roddenberry | Executive Producer |
| Kenny Myers | Makeup Designer |
| Nilo Rodis-Jamero | Costume Design |
| Allan A. Apone | Makeup Designer |
| Douglas E. Wise | First Assistant Director |
| R.A. Rondell | Stunt Double |
| Gregory J. Barnett | Stunt Double |
| Frank Orsatti | Stunts |
| Freddie Hice | Stunts |
| Don Pulford | Stunt Double |
| David R. Ellis | Stunts |
| James M. Halty | Stunts |
| Glenn R. Wilder | Stunt Coordinator |
| Donna Barrett Gilbert | Hairstylist |
| Hazel Catmull | Hairstylist |
| Janice Alexander | Special Effects Makeup Artist |
| Ellis Burman Jr. | Special Effects Makeup Artist |
| Katalin Elek | Special Effects Makeup Artist |
| Jeff Dawn | Makeup Artist |
| Wes Dawn | Makeup Artist |
| Edouard F. Henriques | Special Effects Makeup Artist |
| Rolf John Keppler | Special Effects Makeup Artist |
| Tina Hoffman | Makeup Artist |
| Michael Mills | Special Effects Makeup Artist |
| Erin Koplow | Special Effects Makeup Artist |
| George Fortmuller | Second Assistant Director |
| Doug Hemphill | Sound Re-Recording Mixer |
| Gary Alexander | Sound Re-Recording Mixer |
| Alan Howarth | Sound Effects |
| Chris Jenkins | Sound Re-Recording Mixer |
| David M. Ronne | Sound Mixer |
| Michael Wood | Special Effects |
| Linda Fetters Howard | Stunts |
| David Burton | Stunts |
| Tom Morga | Stunts |
| Terry Jackson | Stunts |
| Tommy J. Huff | Stunts |
| Joyce McNeal | Stunts |
| Scott Wilder | Stunts |
| Bruce Birmelin | Still Photographer |
