 | Will Ferrell als Brennan Huff |
 | John C. Reilly als Dale Doback |
 | Mary Steenburgen als Nancy Huff |
 | Richard Jenkins als Dr. Robert Doback |
 | Adam Scott als Derek |
 | Kathryn Hahn als Alice |
 | Andrea Savage als Denise |
 | Lurie Poston als Tommy |
| Elizabeth Yozamp als Tiffany |
| Logan Manus als Chris Gardoki |
 | Travis T. Flory als Redheaded Kid |
| Lili Rose McKay als 7-Year-Old Girl |
| Shira Piven als Nurse |
 | Seth Morris als Doctor |
 | Wayne Federman als Blind Man |
| Maria Quiban als TV Anchor |
 | Danielle Schneider als Receptionist |
 | Gillian Vigman als Pam Gringe |
 | Brian Huskey als Interviewer |
 | Adam McKay als Man without Glasses |
 | Seth Rogen als Sporting Goods Manager |
 | Chris Henchy als First Homebuyer |
| Mary Catherine Hamelin als First Homebuyer |
 | Ian Roberts als Male Therapist |
 | Erica Vittina Phillips als Second Homebuyer |
 | Phil LaMarr als Second Homebuyer |
 | Rob Riggle als Randy |
 | Jason Davis als TJ |
| Paula Killen als Rental Agent |
 | Ken Jeong als Employment Agent |
 | Horatio Sanz als Lead Singer |
| Kyle Felts als Wine Mixer Heckler |
 | Jake Szymanski als Caterer |
 | Matt Walsh als Drunk Corporate Guy |
 | Dmitri Schuyler-Linch als 6-Year-Old Derek |
 | Bryce Hurless als 9-Year-Old Brennan |
 | Brent White als Therapy Patient |
 | Denise Austin als Herself |
| Clayton Hartley | Production Design |
| Judd Apatow | Producer |
| Adam McKay | Executive Producer |
| Oliver Wood | Director of Photography |
| Adam McKay | Screenplay |
| Will Ferrell | Executive Producer |
| Jimmy Miller | Producer |
| Brent White | Editor |
| Adam McKay | Director |
| Susan Matheson | Costume Design |
| Will Ferrell | Screenplay |
| David B. Householter | Executive Producer |
| Cate Hardman | Script Supervisor |
| Casey Hallenbeck | Set Decoration |
| Adam McKay | Story |
| Jon Brion | Original Music Composer |
| Virginia Randolph-Weaver | Art Direction |
| Will Ferrell | Story |
| Art Rochester | Production Sound Mixer |
| Charlene Amateau | Costume Supervisor |
| John C. Reilly | Story |
| Gemma La Mana | Still Photographer |
| Kevin Kaska | Orchestrator |
| Sonia Izzolena | Stunts |
| Joni Avery | Stunts |
| Hal Willner | Music Supervisor |
| Allison Jones | Casting |
| Basil Grillo | Unit Production Manager |
| Matt Rebenkoff | First Assistant Director |
| Courtenay Miles | Second Assistant Director |
| Josh Church | Co-Producer |
| Andrew Epstein | Associate Producer |
| Jessica Elbaum | Associate Producer |
| Scott Maginnis | Property Master |
| Joe Chess | "A" Camera Operator |
| Michael St. Hilaire | "B" Camera Operator |
| Maricella Ramirez | First Assistant "A" Camera |
| Timothy James Kane | First Assistant "B" Camera |
| Terry Wolcott | Second Assistant "A" Camera |
| Michael D. Alvarez | Second Assistant "B" Camera |
| Annika Iltis | Camera Loader |
| Steve Artmont | Makeup Department Head |
| Bridget Cook | Hair Department Head |
| Simone Almekias-Siegl | Key Makeup Artist |
| Nanci Cascio | Key Hair Stylist |
| James B. Crawford | Chief Lighting Technician |
| Michael A. Russell | Key Costumer |
| Yvonne Bastidos | Costumer |
| Susan Strubel | Costumer |
| Les T. Tomita | Key Grip |
| Michael T. Travers | Best Boy Grip |
| Randall L. Johnson | Boom Operator |
| Paul Murphey | Video Assist Operator |
| Bruce Minkus | Special Effects Coordinator |
| Gerard Averill | Location Manager |
| Kathryn Mindala | Production Accountant |
| Butch West | Construction Coordinator |
| Brook Mansbridge | Construction Foreman |
| James E. Tocci | Set Designer |
| Mark Sakamoto | Leadman |
| Glenn Forbes | Assistant Property Master |
| Will Casey | Unit Publicist |
| Michael Menapace | Transportation Captain |
| James D. D'Amico | Transportation Co-Captain |
| Melissa Bretherton | Additional Editor |
| Michael Hofacre | Assistant Editor |
| George H. Anderson | Supervising Sound Editor |
| Mo Henry | Negative Cutter |
| John Persichetti | Digital Colorist |
| James Matheny | Dialogue Editor |
| Larry Kemp | Dialogue Editor |
| Cindy Marty | Sound Effects Editor |
| Joe Schiff | Sound Effects Editor |
| Tammy Fearing | Supervising ADR Editor |
| Kyle Rochlin | Foley Mixer |
| Howard London | ADR Mixer |
| Pamela Kahn | Foley Artist |
| Vincent Guisetti | Foley Artist |
| Eddie Braun | Stunts |
| Rosine 'Ace' Hatem | Stunts |
| Karine Mauffrey | Utility Stunts |
| Marguerite Pomerhn Derricks | Choreographer |
