 | Patricia Arquette als Frankie Paige |
 | Gabriel Byrne als Father Andrew Kiernan |
 | Jonathan Pryce als Cardinal Daniel Houseman |
 | Nia Long als Donna Chadway |
 | Thomas Kopache als Father Durning |
 | Rade Šerbedžija als Marion Petrocelli |
 | Enrico Colantoni als Father Dario |
 | Dick Latessa als Father Gianni Delmonico |
 | Portia de Rossi als Jennifer Kelliho |
 | Patrick Muldoon als Steven |
 | Ann Cusack als Dr. Reston |
 | Shaun Toub als Doctor |
 | Tom Hodges als ER Nurse |
 | Lydia Hazan als Attending Nurse |
 | Shaun Duke als Dr. Eckworth |
 | Frankie Thorn als Donna's Customer |
| Rupert Wainwright | Director |
| Tom Lazarus | Screenplay |
| Rick Ramage | Screenplay |
| Frank Mancuso Jr. | Producer |
| Elia Cmiral | Original Music Composer |
| Billy Corgan | Original Music Composer |
| Jeffrey L. Kimball | Director of Photography |
| Michael J. Duthie | Editor |
| Michael R. Miller | Editor |
| Wendy Kurtzman | Casting |
| Louise Frogley | Costume Design |
| Waldemar Kalinowski | Production Design |
| Anthony R. Stabley | Art Direction |
| Florence Fellman | Set Decoration |
| Marco Niro | Set Decoration |
| Joyce Kogut | Costume Supervisor |
| Michael Reitz | Hairstylist |
| Barbara Lorenz | Hairstylist |
| Ron Scott | Key Hair Stylist |
| James MacKinnon | Key Makeup Artist |
| Perri Sorel | Key Makeup Artist |
| Raúl Sarmiento | Makeup Artist |
| Michelle Bühler | Makeup Artist |
| Debbie Zoller | Makeup Artist |
| Ve Neill | Makeup Department Head |
| Monica Frommholz | Art Department Coordinator |
| Gregor Habsburg | Art Department Production Assistant |
| Douglas Cumming | Assistant Art Director |
| A. Charles Carnaggio | Assistant Property Master |
| Barry Kingston | Construction Coordinator |
| Brent Rice | Leadman |
| Candi Guterres | On Set Dresser |
| David Q. Quick | Property Master |
| Helen Kozora | Set Decoration Buyer |
| Jody Weisenfeld | Set Decoration Buyer |
| Maria Baker | Set Designer |
| Peter Davidson | Set Designer |
| Barry Lehrman | Set Designer |
| Theodore Sharps | Set Designer |
| Paul Dowler | Set Dresser |
| Jeff Hay | Set Dresser |
| Scott W. Leslie | Set Dresser |
| Steven Light-Orr | Set Dresser |
| René Marquéz | Set Dresser |
| R.A. Tony Poland | Set Dresser |
| Collin Grant | Storyboard Artist |
| Stacy De La Motte | Assistant Camera |
| Michael Thomas | Camera Loader |
| Michael St. Hilaire | Camera Operator |
| Dan Delgado | Chief Lighting Technician |
| Flemming Olsen | Second Unit Director of Photography |
| David Crone | Steadicam Operator |
| Mark Meyers | Dolly Grip |
| David H. Neale | Electrician |
| Ken Nishino | First Assistant "A" Camera |
| Wally Sweeterman | First Assistant "B" Camera |
| Andy Bertelson | Grip |
| Ralph Del Castillo | Grip |
| Rick Grover | Grip |
| J. Michael Popovich | Key Grip |
| Francisco Pintore | Second Assistant Camera |
| John O'Connor | Second Assistant "A" Camera |
| Dale White | Second Assistant "B" Camera |
| Richard Foreman Jr. | Still Photographer |
| David Katz | Video Assist Operator |
| Mark DiSarro | Special Effects Coordinator |
| Al Di Sarro | Special Effects Coordinator |
| Jesus G. Duran | Special Effects Supervisor |
| Thomas Rasada | Special Effects Technician |
| Tim Walkey | Special Effects Technician |
| David Crawford | Compositor |
| Brian Adams | Compositor |
| Rory Hinnen | Compositor |
| Frank Maurer | Compositor |
| Daniel Miller | Compositor |
| David Lauer | Compositor |
| Marc Scott | Digital Compositor |
| Tony Noel | Digital Compositor |
| Blaine Kennison | Digital Effects Supervisor |
| Peter S. Elliot | Visual Effects Editor |
| Joan Collins Carey | Visual Effects Producer |
| George Merkert | Visual Effects Producer |
| David McCullough | Visual Effects Producer |
| Mark Spatny | Visual Effects Production Manager |
| Tim McGovern | Visual Effects Supervisor |
| Jesus G. Duran | Visual Effects Supervisor |
| Avram D. Gold | ADR Editor |
| Curt Schulkey | ADR Editor |
| Doc Kane | ADR Mixer |
| Thomas J. O'Connell | ADR Mixer |
| Troy Porter | ADR Mixer |
| Greg Steele | ADR Mixer |
| Robert Deschaine | ADR Mixer |
| Bryan O. Watkins | ADR Mixer |
| Charleen Richards-Steeves | ADR Mixer |
| Rick Canelli | ADR Recordist |
| David Lucarelli | ADR Recordist |
| Michael Miller | ADR Recordist |
| Jack M. Nietzsche Jr. | Boom Operator |
| Mark Steinbeck | Boom Operator |
| Matthew W. Tenggren | Cableman |
| Hilda Hodges | Foley Artist |
| Rocco Olivo | Foley Artist |
| Alyson Dee Moore | Foley Artist |
| John Roesch | Foley Artist |
| Donald Flick | Foley Editor |
| Mary Jo Lang | Foley Mixer |
| Carolyn Tapp | Foley Recordist |
| Elliott Koretz | Sound Editor |
| Richard L. Anderson | Sound Effects Editor |
| Mike Chock | Sound Effects Editor |
| George Simpson | Sound Effects Editor |
| John Rotondi | Sound Engineer |
| Ezra Dweck | Sound Re-Recording Mixer |
| Scott Millan | Sound Re-Recording Mixer |
| Dennis S. Sands | Sound Re-Recording Mixer |
| Mark A. Mangini | Supervising Sound Editor |
| Rocío Ortega | Animal Wrangler |
| Jeanne Byrd | Script Supervisor |
| Dyanne C. Deuel | Set Medic |
| Christopher James Lopez | Title Designer |
| Diane Van Ussel | Title Designer |
| David Linck | Unit Publicist |
| Charles Page | Construction Foreman |
| Kira Reed Lorsch | Stunt Double |
| Cinda-Lin James | Stunts |
| Tim Gilbert | Stunts |
| Ronnie Rondell Jr. | Stunts |
| Charlie Picerni | Stunts |
| Tom Lazarus | Story |
| Kelsee King-Devoreaux | Stunt Double |
| Masato Chikusa | Additional Photography |
| Rick Avery | Stunts |
| Charlie Brewer | Stunts |
| Joni Avery | Stunts |
| David Barrett | Stunts |
| Mickey Gilbert | Stunts |
| Jared S. Eddo | Stunts |
| Clarke Coleman | Stunts |
| Steve Holladay | Stunts |
| James M. Halty | Stunts |
| Henry Kingi | Stunts |
| Shawn Kautz | Stunts |
| Randy McKenney | Stunts |
| Manny Perry | Stunts |
| Bobby Ore | Stunts |
| Michael Rader | Stunts |
| Steve Picerni | Stunts |
| Pat Romano | Stunts |
| Troy Robinson | Stunts |
| Erik Rondell | Stunts |
| James Ryan | Utility Stunts |
| Joanna Shelmidine | Stunt Driver |
| Christopher J. Tuck | Stunts |
| Miguel Lima | First Assistant Director |
| David Barrett | Second Unit Director |
| Benjamin Rosenberg | First Assistant Director |
| Eric Fox Hays | Second Assistant Director |
| David Crone | "B" Camera Operator |
| Michael St. Hilaire | "A" Camera Operator |
| John Philpotts | Additional Photography |
