 | Will Ferrell als Reggie (voice) |
 | Jamie Foxx als Bug (voice) |
 | Will Forte als Doug |
 | Isla Fisher als Maggie (voice) |
 | Randall Park als Hunter (voice) |
 | Josh Gad als Gus (voice) |
 | Harvey Guillén als Shitstain (voice) |
 | Brett Gelman als Willy |
 | Rob Riggle als Rolf (voice) |
 | Jamie Demetriou als Chester (voice) |
 | Sofía Vergara als Deliliah the Couch (voice) |
 | Greta Lee als Bella (voice) |
 | Jimmy Tatro als Finn (voice) |
 | Jack De Sanz als Munchkin (voice) |
 | Phil Morris als Bubsy (voice) |
 | David Herman als Underbite Pound Dog (voice) |
 | Jaquita Ta'le als Afghan Hound (voice) |
 | Dennis Quaid als Dennis Quaid |
 | Hedy Nasser als Carly |
 | Jade Fernandez als Ashley |
 | Charity Cervantes als Jenna |
 | Aven Lotz als Emma |
 | Hannah Alline als Emma’s Mom |
 | Garrett Hines als Emma’s Dad |
| Mikayla Rousseau als Riley |
 | Mike Dolphy als Riley's Dad |
| Keith Brooks als Steve |
| Dan Perrault als Dr. Hagen |
 | Gabriella Garcia als Teen Girl |
 | Tinashe Kajese als Cathy |
| Josh Greenbaum | Director |
| Phil Lord | Producer |
| Christopher Miller | Producer |
| Dan Perrault | Writer |
| Erik Feig | Producer |
| Louis Leterrier | Producer |
| Aditya Sood | Producer |
| Jessica Switch | Executive Producer |
| Nikki Baida | Executive Producer |
| Julia Hammer | Executive Producer |
| Dara Taylor | Original Music Composer |
| Tim Orr | Director of Photography |
| Rebecca Carfagna | Casting |
| Meagan Lewis | Casting |
| Aaron Osborne | Production Design |
| Samantha LaRoe McDonald | Set Decoration |
| Romy Itzigsohn | Costume Design |
| Katie Ballard | Hair Department Head |
| Karri Farris | Makeup Department Head |
| Bree Tomlinson | Costume Supervisor |
| Lisa Magee | Set Costumer |
| Kara Kimmer | Set Costumer |
| Brian Friedman | Set Designer |
| Britain Illingworth-Cramer | Set Designer |
| Carmen Luse | Set Decoration Buyer |
| Christopher S. Aud | Sound Re-Recording Mixer |
| Christopher S. Aud | Sound Supervisor |
| Beau Borders | Sound Re-Recording Mixer |
| Nancy Nugent | Supervising Sound Editor |
| Randy Torres | Sound Effects Editor |
| Nancy St. John | Visual Effects Producer |
| Leila Nicotera | Visual Effects Producer |
| Maxine Gervais | Colorist |
| Lisa Rodgers | Post Production Supervisor |
| Karthikswamy Sangumani | CG Supervisor |
| Daniel DiPrima | Music Editor |
| J.J. George | Music Editor |
| Yvonne Chan | Script Supervisor |
| Greg Hayden | Editor |
| Sabrina Plisco | Editor |
| David Rennie | Editor |
| Stephen E. Hagen | First Assistant Director |
| Erin Cochran | Art Direction |
| Mike Horton | Foley Artist |
| Jay Meagher | Sound Mixer |
| Jon Title | Sound Designer |
| Dean Tyrrell | Special Effects Coordinator |
| Russell Tyrrell | Special Effects Supervisor |
| Jason Billington | Visual Effects Supervisor |
| David Cvetkovski | Visual Effects Producer |
| Katerina Kalinska | Visual Effects Producer |
| Laurence Chavez | Stunt Coordinator |
| Kurt Hockenberry | Stunt Driver |
| Sean Lyle | Stunts |
| Taylor Towery | Stunts |
| Kevin Waterman | Stunt Double |
| Eric Rick Kline | Grip |
| Josh Quick | Gaffer |
