 | Brandon Routh als Clark Kent / Superman |
 | Kevin Spacey als Lex Luthor |
 | Kate Bosworth als Lois Lane |
 | James Marsden als Richard White |
 | Parker Posey als Kitty Kowalski |
 | Frank Langella als Perry White |
 | Sam Huntington als Jimmy Olsen |
 | Eva Marie Saint als Martha Kent |
 | Marlon Brando als Jor-El |
 | Kal Penn als Stanford |
 | Tristan Lake Leabu als Jason White |
 | David Fabrizio als Brutus |
 | Ian Roberts als Riley |
 | Vincent Stone als Grant |
 | Jack Larson als Bo the Bartender |
 | Noel Neill als Gertrude Vanderworth |
 | Keegan Joyce als Boy with Camera |
 | Jordana Beatty als Little Girl |
 | Rob Flanagan als Bank Gunner |
 | Stephan Bender als 15 Year Old Clark |
 | Peta Wilson als Bobbie-Faye |
 | Jeff Truman als Gil |
 | Barbara Angell als Polly |
 | Ian Bliss als Shuttle Commander |
 | Ansuya Nathan als Shuttle Pilot |
 | Richard Branson als Shuttle Engineer |
 | Warwick Young als 777 Co-Pilot |
 | Bradd Buckley als 777 Navigator |
| Bill Young als Mission Control Flight Director |
 | Karina Bracken als Hospital Ward Nurse |
 | Raelee Hill als Hospital Nurse |
 | Frederique Fouche als French News Anchor (as Frederique Fouché) |
 | Rebecca Barratt als German Reporter |
 | Karen Pang als Hospital Reporter #8 |
 | Jennifer Sciole als EMT (uncredited) |
| Donald MacDonald als British Scientist |
| Lawrence A. Hubbs | Art Direction |
| Roger Mussenden | Casting |
| Jon Peters | Producer |
| Neil Corbould | Special Effects Supervisor |
| Bob Beher | Foley Editor |
| Diane Macke | Project Manager |
| Gilbert Adler | Producer |
| Dan Bradley | Second Unit Director |
| Hugh Bateup | Supervising Art Director |
| Brian Dusting | Set Decoration |
| Catherine Mansill | Art Direction |
| Charlie Revai | Art Direction |
| Bryan Singer | Director |
| Bryan Singer | Producer |
| Bryan Singer | Story |
| John Ottman | Editor |
| John Ottman | Original Music Composer |
| Newton Thomas Sigel | Director of Photography |
| Louise Mingenbach | Costume Design |
| Tora Chung | Assistant Production Coordinator |
| Tami Treadwell | ADR Recordist |
| Ron Bartlett | Additional Sound Re-Recording Mixer |
| R. A. Rondell | Stunt Coordinator |
| Brian Smrz | Second Unit Director |
| Michael Dougherty | Screenplay |
| Michael Dougherty | Story |
| Jerry Siegel | Characters |
| Joe Shuster | Characters |
| Chris Lee | Executive Producer |
| Debbie Denise | Production Supervisor |
| Serkan Zelzele | Visual Effects Compositor |
| Thomas Tull | Executive Producer |
| William Fay | Executive Producer |
| Elliot Graham | Editor |
| Ted Haigh | Graphic Designer |
| Lindsey Hayes Kroeger | Casting Associate |
| Warren Hendriks | First Assistant Sound Editor |
| Andrew R. Jones | Animation Supervisor |
| Maxine Dennett | Set Decoration |
| Andrew G. La Marca | Production Manager |
| Scott Mednick | Executive Producer |
| Ann Robinson | Casting |
| Dan Harris | Screenplay |
| Dan Harris | Story |
| Damon Intrabartolo | Conductor |
| Damon Intrabartolo | Music Arranger |
| David Orr | Color Timer |
| Barbara Harris | ADR Voice Casting |
| Terry Notary | Choreographer |
| Greg Funk | Key Makeup Artist |
| Cameron Ambridge | Stunts |
| Anthony Harris | Digital Color Timer |
| Damien Drew | Art Direction |
| Mark Stetson | Visual Effects Supervisor |
| Roger Fenton | Assistant Editor |
| Neville Page | Costume Illustrator |
| Stephen Jones | Co-Producer |
| Jon Thum | Visual Effects Supervisor |
| Damian Bradford | Stunt Double |
| Guy Hendrix Dyas | Production Design |
| Debbie Evans | Stunt Driver |
| Dan Bronson | Costume Supervisor |
| Chris Kelly | Production Runner |
| David Brighton | Special Effects Assistant |
| Eric Bradley | Musician |
| David E. Campbell | Sound Re-Recording Mixer |
| Craig 'Bart' Bartlett-Sweiger | Grip |
| Richard K. Buoen | Production Illustrator |
| Jeff Julian | Conceptual Design |
| Bruce Lomet | Digital Intermediate Producer |
| Erik Aadahl | Sound Designer |
| Amanda Goodpaster | Music Editor |
| David James | Still Photographer |
| Christopher S. Aud | Sound Effects Editor |
| Stephen Lawes | Digital Colorist |
| Thierry Latremoille | 3D Modeller |
| Hans Bjerno | Aerial Director of Photography |
| Shaun Conway | Gaffer |
| Mary Barltrop | Assistant Location Manager |
| Calum McFarlane | First Assistant "A" Camera |
| Andrea D'Amico | Executive Visual Effects Producer |
| Chris Harvey | Digital Effects Supervisor |
| Ryan Murphy | Sound Mix Technician |
| Kim Santantonio | Key Hair Stylist |
| Pamela Kahn | Foley Artist |
| Howell Gibbens | ADR Editor |
| Gus Duron | Additional Visual Effects |
| Lawrence Karman | Camera Operator |
| Jennifer Cornwell | Unit Production Manager |
| Conrad Dueck | CGI Supervisor |
| Marky Lee Campbell | Utility Stunts |
| Joe Everett | Unit Publicist |
| Andy Wright | ADR Mixer |
| Steven Sallybanks | Scenic Artist |
| Chris Alderton | Sound Recordist |
| Eddie Tang | Chaperone |
| Simeon Bryan | Assistant Camera |
| Nikki Gooley | Hair Designer |
| Simon Harding | Steadicam Operator |
| John Kay | CG Animator |
| Collin Grant | Storyboard Artist |
| Mary E. Manning | 3D Artist |
| Frank Macchia | Orchestrator |
| Melina Burns | Assistant Script |
| Amanda Enders | Set Costumer |
| Hannah Knowlton | Property Master |
| Elizabeth Kenton | Supervising ADR Editor |
| Andrew Chan | Set Designer |
| Richard R. Hoover | Visual Effects Supervisor |
| Carole Cowley | Visual Effects Producer |
| Todd Kolker | Post Production Coordinator |
| Kristin Voumard | Script Supervisor |
| Bill Draper | Executive In Charge Of Production |
| Liza D. Espinas | First Assistant Editor |
| Helen Luttrell | Dialogue Editor |
| Michael J. Malone | Unit Manager |
| Shawn Wallbridge | Systems Administrators & Support |
| Melissa Kostenbauder | Casting Assistant |
| Paula Bonhomme | Digital Producer |
| Jamie Crooks | First Assistant Director |
| Trish Cahill | Colorist |
| Rod Conder | Boom Operator |
| Chris Centrella | Key Grip |
| Tami Lane | Makeup Artist |
| Chris Bond | Visual Effects Supervisor |
| Anthony Mabin | Compositing Supervisor |
| Jason Bayever | CG Supervisor |
| Drew Bailey | Second Second Assistant Director |
| Steven Kaminsky | Post Production Supervisor |
| Matt Broeska | 3D Supervisor |
| Alp Altiner | Matte Painter |
| Kenneth Bailey | Visual Effects |
| Miguel Ortega | 3D Modeller |
| Trish Foreman | Art Department Coordinator |
| John Pickering | Construction Manager |
| Blair Miller | Editorial Production Assistant |
| Dan Owen | Costumer |
| Melissa Binder | Textile Artist |
| David Chornow | Sound Mixer |
| Frank Flick | Additional Camera |
| Bill Neil | VFX Director of Photography |
| Nick McKinnon | Third Assistant Director |
| Kevin Flynn | Transportation Captain |
| Tristian Haddon | Pyrotechnician |
| Stuart Bell | Best Boy Grip |
| Andrea Hood | Key Costumer |
| Nicholas Copping | Production Coordinator |
| Deborah Alleck | Visual Effects Production Manager |
| Maura Gannett | Studio Teacher |
| Christopher Abeyta | Production Accountant |
| Michael Vivian | Dolly Grip |
| Terry Garcia | Assistant Sound Editor |
| Gustavo Balboa | Sculptor |
| Jim Beard | Transportation Coordinator |
| Mark Bills | Lighting Technician |
| Lizi Bedford | Visual Effects Coordinator |
| Ashleigh Carter | Focus Puller |
| Keith W. Smith | Senior Animator |
| Jane Dawkins | Extras Casting |
| Adam Wheatley | Animatronics Designer |
| Rick Newsome | Storyboard Designer |
| Matt Hatton | Conceptual Illustrator |
| Ergin Kuke | VFX Artist |
| Mary Funsten | First Assistant Camera |
| Cristina Patterson | Contact Lens Painter |
| Glenn Finnan | Sound Assistant |
| Christian Luxton | Second Assistant Camera |
| Tony Watt | Carpenter |
| Elizabeth Rice | Wardrobe Assistant |
| Renee D. Czarapata | First Assistant Accountant |
| Ben Aickin | Compositor |
| Toby Barron | Set Dresser |
| Cameron Morley | Additional Second Assistant Camera |
| John Pryce-Jones | Art Direction |
| Jack Mckenzie | Set Decoration |
| Dalia Fernandez | Hairstylist |
| Cindi Knapton | Assistant Art Director |
| Mary-Liz Andrews | Construction Coordinator |
| Loretta Cosgrove | Greensman |
| Kenneth Sayers | Leadman |
| Katherine Geaney | Props |
| Arran Gordon | Special Effects |
| Juliana D'Costa | 3D Animator |
| Michael Comly | Lighting Artist |
| Shih Chiang Kenny Huang | Modeling |
| Walt Jones | Sequence Supervisor |
| David Scott | Visual Effects Art Director |
| Robert Auten | Visual Effects Editor |
| Daniel Carlisle | Electrician |
| Thomas Vanasse | Video Assist Operator |
| Carin Richardson | Assistant Costume Designer |
| Peter Woods | Post Production Assistant |
| Jean Chien | Location Manager |
| James Lin | Location Scout |
| George A. Miki | Driver |
| Tere Alexeeff | Armorer |
| John Higgins | Dialect Coach |
| Carl Blacklidge | Marine Coordinator |
| Jon Ko | Set Medic |
| Rama Dunayevich | Public Relations |
| Alex Betuel | Set Production Assistant |
| Sanjit Patel | Software Engineer |
| Jamie Vergan | Stand In |
| Simon Clowes | Storyboard Artist |
| Tim Dobbert | Matchmove Supervisor |
| Cynthia Aragon | Rotoscoping Artist |
| Gene A. Lewis Jr. | Visual Effects Production Assistant |
| Jim Sheedy | Additional Grip |
| Malcolm Eager | Data Wrangler |
| Phillip Cappe | Title Designer |
| Brian Adams | Digital Compositor |
| Peter Sidell | Art Department Assistant |
| Abbie Mawhinney | Costume Assistant |
| Patricia Barker | Tailor |
| Renae Begent | Additional Third Assistant Director |
| James Nicholas | Assistant Director |
| Naomi Enfield | Second Assistant Director |
| Nick Tory | Draughtsman |
| Phillip Beadsmoore | Special Effects Technician |
| Christos Obretenov | Visual Effects Technical Director |
| Andrea Berchtold | Stunt Driver |
| Tim Cousins | Libra Head Technician |
| Catherine Elvidge | Lead Animator |
| Michael Schiavone | Additional Casting |
| Belinda Cahill | Assistant Accountant |
| Kim Gladman | Assistant Unit Manager |
| Andrea Yelle | Human Resources |
| Frank Du | Pipeline Technical Director |
| Andrew McDougall | Pre-Visualization Coordinator |
| Nancy A. Accomando | Production Assistant |
| Kate Royce Walters | Production Secretary |
| Dominique Arcadio | Researcher |
| Stuart Frossell | Senior Modeller |
| Ingrid Kleinig | Stunts |
| David R. Morton | VFX Artist |
| Hiroshi Mori | Visual Effects |
| Ian Fried | Production Intern |
| Tomoko Yamamoto | Second Assistant Accountant |
