 | Eddie Murphy als Pluto Nash |
 | Randy Quaid als Bruno |
 | Rosario Dawson als Dina Lake |
 | Joe Pantoliano als Mogan |
 | Jay Mohr als Tony Francis |
 | Luis Guzmán als Felix Laranga |
 | James Rebhorn als Belcher |
 | Peter Boyle als Rowland |
 | Burt Young als Gino |
 | Miguel A. Núñez Jr. als Miguel |
 | Pam Grier als Flura Nash |
 | John Cleese als James |
 | Victor Varnado als Kelp |
 | Illeana Douglas als Dr. Mona Zimmer |
 | Jacynthe René als Babette |
 | Alissa Kramer als Gina Francis |
 | Heidi Kramer als Filomina Francis |
 | Lillo Brancato als Larry |
 | Alex Sol als Tommy |
 | Doug Spinuzza als Doug |
 | Andrée Fafard als Holographic Spokesmodel |
 | Stu 'Large' Riley als Club Pluto Bouncer |
 | Roc LaFortune als Jimmy |
 | Russell Yuen als Oliver |
 | Alec Baldwin als M.Z.M |
 | Michael Rudder als Croupier |
| Oliver Wood | Director of Photography |
| Neil Cuthbert | Screenplay |
| Paul Hirsch | Editor |
| Ron Underwood | Director |
| Martin Bregman | Producer |
| Michael Bregman | Producer |
| John Powell | Original Music Composer |
| Alan Heim | Editor |
| Louis A. Stroller | Producer |
| Mary Colquhoun | Casting |
| Nick Davis | Visual Effects Supervisor |
| Frank Capra III | Co-Producer |
| Michael Klawitter | Co-Producer |
| Ha Nguyen | Costume Design |
| Bill Brzeski | Production Design |
| Bruce Berman | Executive Producer |
| Frank Capra III | First Assistant Director |
| Christina Kontos | Production Manager |
| Anne Alloucherie | Second Assistant Director |
| Alan Oliney | Stunt Coordinator |
| Michael Scherer | Stunt Coordinator |
| Jim Kontos | Unit Manager |
| Danielle Boucher | Production Coordinator |
| Guylaine Boucher | Assistant Production Coordinator |
| Shepherd Frankel | Supervising Art Director |
| William D. Barber | "A" Camera Operator |
| François Daignault | "B" Camera Operator |
| François Daignault | Steadicam Operator |
| Rob Morey | First Assistant "A" Camera |
| Michel Bernier | First Assistant "B" Camera |
| Claude Beauchamp | Second Assistant "A" Camera |
| Jean Kavanagh | Clapper Loader |
| Patrick Rousseau | Sound Mixer |
| Louis Piché | Boom Operator |
| Gilles Aird | Art Direction |
| Jason Weil | Art Direction |
| Jean Kazemirchuk | Assistant Art Director |
| Raynald Langelier | Assistant Art Director |
| Brana Rosenfeld | Set Decoration |
| Wayne Shepherd | Leadman |
| Annette Bélanger | Art Department Coordinator |
| Viviane Vallée | Art Department Coordinator |
| Joseph Lang Browns | Set Designer |
| Félix Larivière-Charron | Set Designer |
| John Dexter | Set Designer |
| A. Todd Holland | Set Designer |
| Michele Laliberte | Set Designer |
| Céline Lampron | Set Designer |
| Russell Moore | Set Designer |
| Colin De Rouin | Set Designer |
| Charlotte Rouleau | Set Designer |
| Dianne Wager | Set Designer |
| Elise de Blois | Set Dresser |
| Robert Parle | Set Dresser |
| Vincent Aird | Set Dresser |
| Marie-Claude Guay | Set Dresser |
| James Carson | Production Illustrator |
| Ed Natividad | Production Illustrator |
| Simon Murton | Production Illustrator |
| Philip Toolin | Production Illustrator |
| Timothy Burgard | Storyboard Artist |
| Michael Anthony Jackson | Storyboard Artist |
| Marie-Agnés Reeves | Storyboard Artist |
| Tom Southwell | Storyboard Artist |
| Isabelle Côté | Graphic Designer |
| Will Blount | Property Master |
| Claire Alary | Assistant Property Master |
| Garry Elmendorf | Special Effects Coordinator |
| Melissa Bretherton | Visual Effects Editor |
| Jim Flynn | First Assistant Editor |
| Tricia Miles | Post Production Supervisor |
| Charlene Amateau | Costume Supervisor |
| Lizzie McGovern | Assistant Costume Designer |
| Simonetta Mariano | Wardrobe Coordinator |
| Jocelyne Bellemare | Key Makeup Artist |
| Vera Steimberg | Makeup Artist |
| Gillian Chandler | Makeup Artist |
| Adrien Morot | Special Effects Makeup Artist |
| Bruno Gatien | Prosthetic Makeup Artist |
| Stacey Morris | Hairstylist |
| Manon Joly | Hairstylist |
| Céline Daignault | Location Manager |
| Monique Champagne | Script Supervisor |
| Thomas A. Davila | Production Controller |
| Gregory D. Hemstreet | Production Accountant |
| Pota Manolakos | Production Accountant |
| Julie Breton | Extras Casting |
| Bruce McBroom | Still Photographer |
| Jonathan Wenk | Still Photographer |
| Deborah Simmrin | Unit Publicist |
| James B. Crawford | Gaffer |
| John Lewin | Gaffer |
| Keith Kerr | Best Boy Grip |
| Patrick Lima | Dolly Grip |
| Andy Koyama | Sound Re-Recording Mixer |
| Chris Carpenter | Sound Re-Recording Mixer |
| Steve Maslow | Sound Re-Recording Mixer |
| Gregg Landaker | Sound Re-Recording Mixer |
| Gayle Wesley | First Assistant Sound Editor |
| Branden Spencer | First Assistant Sound Editor |
| Bill Meadows | Sound Recordist |
| Brion Paccassi | Sound Recordist |
| Frank Fleming | Sound Recordist |
| Craig S. Jaeger | Foley Supervisor |
| James Moriana | Foley Artist |
| Jeffrey Wilhoit | Foley Artist |
| Peter Staubli | Foley Editor |
| Bunny Andrews | Music Editor |
| Mo Henry | Negative Cutter |
| David Orr | Color Timer |
