 | Michelle Rodriguez als Frank Kitchen / Tomboy |
 | Sigourney Weaver als Dr. Rachel Kay |
 | Tony Shalhoub als Dr. Ralph Galen |
 | Caitlin Gerard als Johnnie |
 | Anthony LaPaglia als Honest John Hartunian |
 | Paul McGillion als Paul Wincott |
 | Ken Kirzinger als Nurse Albert Becker |
 | Paul Lazenby als Bodyguard |
 | Zak Santiago als Edward Gonzales |
 | Adrian Hough als Sebastian |
 | Alex Zahara als Vladimir Gorski |
 | Chad Riley als Merchado |
 | Jason Asuncion als Hiram Ko (Dog Trainer) |
 | Darryl Quon als Jin Tao |
 | Hugo Ateo als Guzman |
 | Sergio Osuna als Mexican Man |
 | Terry Chen als Dr. Lin |
 | Lauro Chartrand als Cousin in Vegas |
 | Caroline Chan als Ting Li |
 | Lia Lam als Asian woman |
 | Eltie Pearce als Whitney |
| Denis Hamill | Story |
| Walter Hill | Director |
| James Liston | Director of Photography |
| Renée Read | Production Design |
| Raney Shockne | Original Music Composer |
| Michel Merkt | Producer |
| Giorgio Moroder | Original Music Composer |
| Phil Norden | Editor |
| Saïd Ben Saïd | Producer |
| Walter Hill | Story |
| Kenneth Burke | Line Producer |
| Todd Giroux | Associate Producer |
| John Lind | Co-Producer |
| Walter Hill | Screenplay |
| Sarah Borch-Jacobsen | Producer |
| Kevin Chneiweiss | Associate Producer |
| Denis Hamill | Screenplay |
| Claudio Sepulveda | Digital Intermediate |
| Reid Cohoon | Key Grip |
| Brian Campbell | ADR Editor |
| Bill Mellow | Sound Re-Recording Mixer |
| Ana Oparnica Sebal | Script Supervisor |
| James Fonnyadt | Sound Designer |
| Bill Mills | Special Effects Coordinator |
| Daniel Cardona | Sound Re-Recording Mixer |
| Jessica Rain | Hairstylist |
| Bruce Borland | Camera Operator |
| Katie Yu | Still Photographer |
| James M. Jackson | Gaffer |
| Bryson Dodwell | Sound Effects Editor |
| Kelly Cole | Sound Re-Recording Mixer |
| Kris Wood | Visual Effects Supervisor |
| Dale H. Jahraus | Camera Operator |
| Sheila Jaffe | Casting |
| Julian Chapdelaine | Dolly Grip |
| Ian Doig | Animal Coordinator |
| Brian Campbell | Dialogue Editor |
| A. Blair Stevens | Set Decoration |
| Courtney Frey | Makeup Department Head |
| Meredith Garstin | Set Decoration |
| Candice Elzinga | Casting |
| Geena Renk | Visual Effects Producer |
| Cameron Root | Lighting Technician |
| Jason Weir | Lighting Technician |
| Ellen Anderson | Costume Design |
| Kelly Thorburn | Animal Wrangler |
| Alexia S. Droz | Production Manager |
| Melissa R. Stubbs | Stunt Coordinator |
| Daniel Cardona | Recording Supervision |
| Kelly Cole | Mixing Engineer |
| Karim El-Masry | Digital Compositors |
| Joel Echallier | Makeup Effects Designer |
| John Lind | First Assistant Director |
| Sandra Couldwell | Casting |
| Melissa Reese | Compositors |
| Yash Gowda | Digital Compositors |
| Paul Lazenby | Stunts |
| Jess Brown | Visual Effects Producer |
| Jason Asuncion | Stunts |
| Kyle Sevier | Location Manager |
| Sarah Tichenor | Production Accountant |
| Kelly Cole | Supervising Sound Editor |
| Janani Sridhar | Digital Compositors |
| Suzan Derkson | Production Manager |
| Annabelle Wilczur | Second Assistant Director |
| Bill Mellow | Mixing Engineer |
| Agnieszka Echallier | Makeup Effects |
| Isabel Bloor | Set Dressing Supervisor |
| Bill Mellow | Supervising Sound Editor |
| Brent Boulet | Visual Effects Supervisor |
| Audrey Hellmer | Production Coordinator |
| Ashley Sawyer | Third Assistant Director |
| Kenneth Burke | Unit Production Manager |
| Harvey Kahn | Producer |
