 | Anthony Conti als Jacob Aceto |
 | J.K. Simmons als Ralph Aceto |
 | Laura Dern als Doctor |
 | David Lynch als Man In Black |
 | Richard Chamberlain als Creepy Oncologist |
 | Johnny Depp als Nuclear Med Tech |
 | John Grady als Blackened Corpse |
 | Jade Pettyjohn als Bri Alonso |
 | Chad L. Coleman als Tanner Alonso |
 | Keith Allan als Jonathan King |
 | Pritesh Shah als Beemo |
 | Penelope Ann Miller als Ghiandola Anita Aceto |
 | Nancy Berggren als Elderly Ghiandola |
 | Lisa Roumain als Decayed Ghiandola |
| Gary D. Hancock als Petrified Ghiandola |
| Jes Selane als Rotted Ghiandola |
| Keith Sclon als Schoolboy Ghiandola |
| Maria Huggins als Teenage Ghiandola |
| Eloisa Huggins als Young Ghiandola |
| Olivia Simmons als Schoolgirl Ghiandola |
| Catherine Hardwicke | Director |
| Theodore Melfi | Director |
| Sam Raimi | Director |
| Anthony Conti | Writer |
| Scott Kosar | Writer |
| Wash Westmoreland | Writer |
| Marco Fargnoli | Director of Photography |
| Lisa Robison | Editor |
| Atticus Ross | Original Music Composer |
| Trent Reznor | Original Music Composer |
| Tamika Lamison | Producer |
| Bettina Fisher | Producer |
| Adele René | Producer |
| Alexandra Hancock | Co-Producer |
| Adele René | Casting |
| Susan Benjamin | Production Design |
| Marilyn Vance | Costume Designer |
| Zachery Ty Bryan | Executive Producer |
| JB Carlin | Executive Producer |
| Jenna Hagel | Executive Producer |
| Mark Williams | Additional Director of Photography |
| Chris Beal | Line Producer |
| Michael Phillip Edwards | Associate Producer |
| Willis S. Davidson | Associate Producer |
| Ellen Dumouchel | Associate Producer |
| Mike Rizzuto | Associate Producer |
| Cristen Coppen | Associate Producer |
| Jeffrey Cordone | Line Producer |
| Dustin Garnett | Unit Production Manager |
| Patricia Seely | Unit Production Manager |
| Larry Krask | First Assistant Director |
| Jorelle Miranda | Assistant Editor |
| Jon Anctil | Assistant Editor |
| Johanna Ray | Casting Consultant |
| Craig Campobasso | Casting Consultant |
| Michael Phillip Edwards | First Assistant Director |
| Darin Munnell | Second Assistant Director |
| Nathan D. Snyder | Second Second Assistant Director |
| Tim Mikulecky | Stunt Coordinator |
| Kevin Dunigan | Stunt Coordinator |
| Ken Arata | Stunt Double |
| Lisa Hoyle | Stunt Double |
| Betty Bailey | Production Coordinator |
| Dakota Bailey | Production Coordinator |
| Claire White | Art Direction |
| Emma Sparer | Assistant Art Director |
| Andrew Adams | Leadman |
| Kelley Pearce | Set Decoration |
| Julia Ryan | Set Decorating Coordinator |
| J.P. Jones | Property Master |
| Skye Jones | Property Master |
| Ben Hardwicke | Camera Operator |
| Doug Oh | Camera Operator |
| Heather Brown | Camera Operator |
| Nick Franco | Camera Operator |
| Patrick Rousseau | Camera Operator |
| Jarrod Oswald | First Assistant Camera |
| Joe Provozano | First Assistant Camera |
| Nate Apffel | First Assistant Camera |
| Seth Kotok | First Assistant Camera |
| Dylan Neal | First Assistant Camera |
| Jeff Saldin | Second Assistant Camera |
| Olivia Kelly | Second Assistant Camera |
| Sooz Edie | Second Assistant Camera |
| Trevor Beeler | Second Assistant Camera |
| Dan Moretti | Sound |
| Dave Girtsman | Sound |
| Garret Barnett | Sound |
| Jackson Tubbs | Sound |
| Kevin O'Farrell | Sound |
| Phil Brewster | Sound |
| Wesley Claggett | Sound |
| Cendra Martel | Assistant Costume Designer |
| Kaila Borne | Makeup Artist |
| Keely Maroney | Makeup Artist |
| Kristen Calderon | Makeup Artist |
| Monica Halligan | Makeup Artist |
| Shannon Mansion | Makeup Artist |
| Mecca Dickerson | Makeup Artist |
| Betty Bailey | Script Supervisor |
| Linda Lifer | Script Supervisor |
| Mary Anne Seward | Script Supervisor |
| Rob F. Goodwin | Script Supervisor |
| Sally Boldt | Music Editor |
| Ash Ignatius | Title Designer |
| Nate Apffel | Additional Photography |
| Gary Megregian | Supervising Sound Editor |
| Timothy A. Cleveland | Sound Designer |
| Judah Getz | ADR Mixer |
| Craig Mann | Sound Re-Recording Mixer |
| Laura Wiest | Sound Re-Recording Mixer |
| Nick Papalia | Assistant Dialogue Editor |
| Jonathan Corona | Assistant Dialogue Editor |
| Paul J. Diller | Sound Effects Editor |
| John Snider | Sound Effects Editor |
| Jason Krane | Dialogue Editor |
| Jason Krane | ADR Editor |
| Antony Zeller | Foley Mixer |
| Zane Brue | Foley Artist |
| Lindsay Pepper | Foley Artist |
| Jason Fabbro | Digital Intermediate Colorist |
| Mark Sahagun | Digital Intermediate Editor |
| Julian McDougald | Digital Intermediate Producer |
