 | Denzel Washington als Lincoln Rhyme |
 | Angelina Jolie als Amelia Donaghy |
 | Queen Latifah als Thelma |
 | Michael Rooker als Captain Howard Cheney |
 | Michael McGlone als Detective Kenny Solomon |
 | Luis Guzmán als Eddie Ortiz |
 | Leland Orser als Richard Thompson |
 | John Benjamin Hickey als Dr. Barry Lehman |
 | Bobby Cannavale als Steve, Amelia's Boyfriend |
 | Ed O'Neill als Detective Paulie Sellitto |
 | Richard Zeman als Lieutenant Carl Hanson |
 | Olivia Birkelund als Lindsay Rubin |
 | Gary Swanson als Alan Rubin |
 | James Bulleit als Train Engineer |
 | Frank Fontaine als Grandfather |
 | Zena Grey als Granddaughter |
 | Desmond Campbell als Taxi Inspector |
 | Peter Michael Dillon als Homicide Detective |
 | Ted Whittall als Ortiz's Assistant |
 | Andy Bradshaw als Uniform Cop |
 | Steve Adams als Gas Worker |
| Christian Veliz als Young Boy |
| Mercedes Gómez als Ortiz's Mother |
| Mary C. Hammett als Girlfriend in Nightclub |
| Amanda Gay als Girl in Nightclub |
 | Larry Day als Gas Worker |
| Burke Lawrence als Police Instructor |
| Terry Simpson als Cop in Apartment |
 | Eric Davis als Cop in Apartment |
 | Arthur Holden als Bookstore Clerk |
 | Yahsmin Daviault als Rhyme's Sister |
| Keenan MacWilliam als Rhyme's Niece |
 | David Warshofsky als Amelia's Partner |
 | Mateo Gómez als Hot Dog Vendor |
| Jonathan Stark als Male Detective |
 | Fulvio Cecere als Forensics Expert |
| Hal Sherman als Fingerprint Cop |
 | Russell Yuen als Forensics Worker |
| Jean-Marc Bisson als Rescue Worker |
| Christopher Bregman als Rescue Worker |
| Sonya Biddle als Nurse |
| Lance Brown | Additional Sound Re-Recording Mixer |
| Dan Jinks | Executive Producer |
| Martin Bregman | Producer |
| William Hoy | Editor |
| Tony Pierce-Roberts | Additional Photography |
| Dean Semler | Director of Photography |
| Craig Armstrong | Original Music Composer |
| Doc Kane | ADR Mixer |
| Nigel Phelps | Production Design |
| Jon Billington | Assistant Art Director |
| Martin Cantwell | Assistant Sound Editor |
| Phillip Noyce | Director |
| Larry M. Cherry | Hairstylist |
| Andrea Kenyon | Casting |
| Claude Paré | Supervising Art Director |
| Simon Kaye | Production Sound Mixer |
| Stephen Hilton | Music Programmer |
| Gilles Fortier | Rigging Gaffer |
| Myriam Vézina | Casting |
| Bernard Telsey | Casting |
| Jefferson Sage | Supervising Art Director |
| Marie-Claude Gosselin | Set Decoration |
| Alan Holly | ADR Mixer |
| Michael Bregman | Producer |
| Jeffery Deaver | Novel |
| Jeremy Iacone | Screenplay |
| Michael Klawitter | Executive Producer |
| Louis A. Stroller | Producer |
| John Coniglio | First Assistant Editor |
| Mike Benson | Additional Photography |
| Andrew S. Eisen | Additional Editing |
| Matthew Gray | Set Designer |
| Matthew Gray | Draughtsman |
| George Acogny | Music Supervisor |
| Adrien Morot | Prosthetic Makeup Artist |
| François Grenon | Boom Operator |
| Jean Frenette | Stunt Coordinator |
| Mathieu Charest | Key Grip |
| Kymbra Callaghan | Makeup Artist |
| Jan Foster | Production Manager |
| Lisa R. Frucht | Wardrobe Supervisor |
| Deirdre N. Williams | Wardrobe Supervisor |
| Deborah Parker | Location Manager |
| Bill Anagnos | Stunts |
| Mai Iskander | Second Assistant Camera |
| Bo Dietl | Associate Producer |
| Mark Nelmes | Digital Effects Supervisor |
| Michael Russo | Stunt Coordinator |
| Eric Kutner | Electrician |
| Robert Grasmere | Visual Effects Supervisor |
| Craig Haagensen | Second Unit Director of Photography |
| Odette Gadoury | Costume Design |
| Christopher Bregman | Third Assistant Director |
| Bruce Stambler | Supervising Sound Editor |
| Jon Thum | Compositing Artist |
| François Legris | Electrician |
| Will Cantler | Casting |
| David Vacarri | Casting |
| Geoffrey Erb | Second Unit Director of Photography |
| Janeen Schreyer | Makeup Artist |
| Jery Hewitt | Stunt Coordinator |
| Frank Perry Rose | Dresser |
| Lyse Pomerleau | Wardrobe Coordinator |
| Susan C. MacQuarrie | Set Decoration |
| Susan C. MacQuarrie | Set Dresser |
| Harriet Zucker | Set Decoration |
| Daniele Léger | Costume Supervisor |
| Daniele Léger | Assistant Costume Designer |
| Dan O'Connell | Foley Artist |
| Jeanette Haley | Post Production Coordinator |
| Richard Todman | Assistant Dialogue Editor |
| Tom Debenham | Compositing Artist |
| Dominic Parker | CG Animator |
| David E. Campbell | Sound Re-Recording Mixer |
| Gregg Rudloff | Sound Re-Recording Mixer |
| John T. Reitz | Sound Re-Recording Mixer |
| Robert Troy | Dialogue Editor |
| John T. Cucci | Foley Artist |
| David Crone | Steadicam Operator |
| Carl Fullerton | Makeup Artist |
| Daniel Matthews | Transportation Coordinator |
| Eric Béliveau | Transportation Captain |
| Michel Brochu | Construction Coordinator |
| Rejean Brochu | Construction Coordinator |
| Claire Alary | Assistant Property Master |
| Takashi Seida | Still Photographer |
| Joe E. Rand | Music Editor |
| Paddy Eason | Compositing Artist |
| John Lewin | Gaffer |
| James J. Gilson | Gaffer |
| Linda Lew | Foley Recordist |
| Patrick B. O'Brien | First Assistant Camera |
| Wayne Paull | Camera Operator |
| Réjean Forget | Key Hair Stylist |
| Doris Simard | Art Department Coordinator |
| Eames Gagnon | Best Boy Electric |
| K.C. Bailey | Still Photographer |
| Douglas Fox | Property Master |
| René Guillard | Gaffer |
| Charles Hamilton | Sound Recordist |
| Kathryn Casault | Makeup Artist |
| C.J. Goldman | Makeup Effects |
| Christina Kontos | Production Manager |
| Raymond M. Samitz | Construction Coordinator |
| Elizabeth Schlitten | Property Master |
| Colin Miller | Supervising Sound Editor |
| Christopher Ackland | Dialogue Editor |
| Jessica Gallavan | ADR Supervisor |
| Francis Marleau | Special Effects Coordinator |
| Rachael Penfold | Visual Effects Producer |
| Dean Crone | Camera Operator |
| Jonathan Wenk | Still Photographer |
| Julie Sageau | Video Assist Operator |
| Joel Holland | Video Assist Operator |
| Nadine Demeule | Video Assist Operator |
| Peter Girolami | Gaffer |
| François Fauteux | Location Manager |
| Lorraine Jamison | Unit Publicist |
| Barbara Stoia | Script Supervisor |
| Barry Idoine | First Assistant Camera |
| Pam Aaron | Wardrobe Supervisor |
| William Cawley | Sound Assistant |
| Robert Parle | Assistant Set Dresser |
| Julie Casault | Assistant Makeup Artist |
| Christian Biron | Assistant Location Manager |
| Alison Kelly | Second Assistant Camera |
| Thomas O'Connor | Electrician |
| Daniel R. Chavez | Executive In Charge Of Post Production |
| Louis-René Landry | Draughtsman |
| Claude Leclair | Assistant Set Dresser |
| Roy Bryson | Hairstylist |
| Paul Aulicino | First Assistant Sound Editor |
| Stephen Murphy | CG Animator |
| Simon Guilbault | Draughtsman |
| Denis Côté | Swing |
| Billy Patsos | Key Grip |
| Patrick Mahoney | Craft Service |
| Noga Isackson | First Assistant Director |
| Dan Glass | CG Animator |
| John Charles | Software Team Lead |
| Allan Byer | Production Sound Mixer |
| Monique Champagne | Script Supervisor |
| Jennifer Lamb | Stunts |
| Linda Murphy | Boom Operator |
| Mike Stanwick | Color Timer |
| James Ashwill | Foley Mixer |
| George Dickson | Post Production Assistant |
| Eric Lafrance | Carpenter |
| Danielle Boucher | Production Coordinator |
| Nicolas Marion | First Assistant Camera |
| Avery Gibbard | Wardrobe Assistant |
| Robert Dawson | Title Designer |
| Alain Bisson Doyal | Rigging Grip |
| Charles-André Bertrand | Assistant Set Dresser |
| Charles-André Bertrand | Second Assistant Director |
| Michael Arthur | Stunt Driver |
| Michael Dressel | Foley Supervisor |
| Jim Kontos | Unit Manager |
| Louise Cova | Assistant Set Dresser |
| Karl Wasserman | Cableman |
| Maggie Kusik | Production Accountant |
| Jacques Leroide | Foley Editor |
| Gary Burritt | Negative Cutter |
| William 'Bear' Paul | Key Grip |
| Bill Richards | Aerial Coordinator |
| Ralph Contrado | Scenic Artist |
| Nicole Stiegelbauer | Standby Painter |
| Jacques F. Bernier | First Assistant Camera |
| Robert Allicock | Hairstylist |
| Jason 'Jay' Brown | Set Dressing Artist |
| Vito G. Balenzano | Driver |
| Jonathan Goldman | Second Unit Director |
| Stephen Krug | Set Production Assistant |
| Mark Akeson | Stand In |
| Ricky Friedman | Assistant Director |
| Damian Gonzales | Electrician |
| Micael Albrecht | Lighting Technician |
| Oliver James | Researcher |
| Alex Maleev | Storyboard Artist |
| Guylaine Boucher | Assistant Production Coordinator |
| Louis Elman | ADR Voice Casting |
| Bradley Clouse | Sound Assistant |
| Gus Papadopoulos | Set Dresser |
| David Sutton | Boom Operator |
| Catherine Gélinas | Dresser |
| Sylvie Chaput | Seamstress |
| Hannah Walker Edwards | CG Animator |
| Larry Orlick | First Assistant Camera |
| Richard Clarke | CG Animator |
| Gavin Toomey | Compositing Artist |
| Ginette Cérat-Lajeunesse | Assistant Hairstylist |
| John W. Murphy | Dolly Grip |
| Kenneth G. Brown | Second Second Assistant Director |
| Joanne Lamstein | Stunts |
| Tara McNamee | Stunt Double |
| Carl Lessard | Graphic Designer |
| Sébastien Gervais | Swing |
| Claude Gervais | Swing |
| Courtney Henley-Anderson | Production Assistant |
| Eric Stepper | Property Master |
| Braden Belmonte | Clapper Loader |
| Pierre Côté | Special Effects Technician |
| Anne Alloucherie | Second Assistant Director |
| Agnieszka Kroskowska | Additional Third Assistant Director |
| Terry Eckert | Best Boy Grip |
| Patrick Bernier | Second Assistant Camera |
| Cecilia Weston | Conductor |
| Sarah Dolan | Music Coordinator |
| Catherine Lavoie | Assistant Script |
| Marie Portelance | Assistant Unit Manager |
| Sonny Rea | Key Rigging Grip |
| Sonny Rea | Key Production Assistant |
| Teena Deocales | Production Secretary |
| James Pollard | Dolly Grip |
| Jeff Scott | Electrician |
| Josée Comeau | Seamstress |
| Sophie Godard | Dresser |
| Ève Boulonne | Set Dresser |
| Christian Lemay | Second Assistant Camera |
| Patrick Jean-Joseph | Second Assistant Camera |
| Patrick Mangan | Second Assistant Director |
| Regina Sabat-Dhouib | Assistant Director Trainee |
| Josceline Genest | Art Department Assistant |
| Diane Pagé | Art Department Assistant |
| Réal Paré | Art Department Assistant |
| Christina Hong | Art Department Assistant |
| Gina Hendricks | Assistant Property Master |
| Claude Jacques | Assistant Set Dresser |
| Jean-Guy LeBlanc | Assistant Set Dresser |
| Joseph Lang Browns | Draughtsman |
| Karine Charobert | Painter |
| Mario Paré | Painter |
| Étienne Bédard | Painter |
| Eric Brassard | Swing |
| Walter Byrns | Swing |
| Michel L'Heureux | Dresser |
| Josée Philibert | Dresser |
| Marie-Etienne Bessette | Wardrobe Assistant |
| Richard Blackburn | Electrician |
| Christian Grenier | Electrician |
| John Bagley | Electrician |
| John McAleer | First Assistant Camera |
| Jean-Pierre Lamarche | Key Grip |
| Claude Pothier | Rigging Gaffer |
