 | Alec Baldwin als Theodore Templeton (voice) |
 | James Marsden als Tim Templeton (voice) |
 | Amy Sedaris als Tina Templeton (voice) |
 | Jeff Goldblum als Dr. Armstrong (voice) |
 | Eva Longoria als Carol Templeton (voice) |
 | Lisa Kudrow als Janice Templeton (voice) |
 | Jimmy Kimmel als Ted Templeton (voice) |
 | Ariana Greenblatt als Tabitha Templeton (voice) |
 | James McGrath als Wizzie (voice) |
 | Raphael Alejandro als Nathan (voice) |
 | Serenity Reign Brown als Meghan (voice) |
| David Soren als Jimbo (voice) |
| Molly K. Gray als Creepy Girl (voice) |
 | Ashlyn Lundahl als 'No' Girl (voice) |
 | Tom McGrath als Dr. Tiffany Hamilton (voice) |
 | Reyn Doi als Box Kid (voice) |
 | Walt Dohrn als Baby Bouncer (voice) |
| April Lawrence als Acorn Center Computer (voice) |
 | Miles Bakshi als Young Tim Voice-Over (voice) |
| Marjorie Cohn als Pageant Mom 2 (voice) (as Margie Cohn) |
| Nicholas Gist als Les triplés (voice) |
| Collin Erker als Enfant temps mort (voice) |
| Kristin Lowe als Maman spectacle 1 (voice) |
| Margie Cohn als Maman spectacle 2 (voice) |
| Connor Albrecht als Dreidel Kid (voice) |
| Hans Zimmer | Original Music Composer |
| Mark A. Hester | Editor |
| Michael McCullers | Characters |
| Michael McCullers | Writer |
| Michael McCullers | Story |
| Tom McGrath | Director |
| Tom McGrath | Story |
| Beau Borders | Sound Re-Recording Mixer |
| John Swanson | Associate Producer |
| Steve Mazzaro | Original Music Composer |
| Michael J. Broomberg | Foley Artist |
| Christi Soper Hilt | Casting |
| Paul N.J. Ottosson | Sound Designer |
| Paul N.J. Ottosson | Supervising Sound Editor |
| Christian Schaanning | Sound Effects Editor |
| James Morioka | Dialogue Editor |
| Andy Schuhler | Art Direction |
| Raymond Zibach | Production Design |
| Luke Schwarzweller | Sound Mix Technician |
| Pedro Eustache | Musician |
| Nelson Yokota | Storyboard Artist |
| Marla Frazee | Producer |
| Marla Frazee | Novel |
| Christopher Brock | Art Direction |
| Matt Yocum | Sound Effects Editor |
| Jeff Hermann | Producer |
| Andrew Harkins | Animation |
| Mary Blee | Editor |
| Stephen Wood | Special Effects |
| Jon Eric Schmidt | Associate Producer |
| Jacob Collier | Music |
| Lisa Curtis Saunders | Pipeline Technical Director |
| Angelo Raguso | Sound Mixer |
| Carl Roberts | Foley Recordist |
| Christopher Gonzalez | Animation |
