 | Jack Nicholson als Edward Periman Cole |
 | Morgan Freeman als Carter Chambers |
 | Sean Hayes als Thomas |
 | Beverly Todd als Virginia Chambers |
 | Alfonso Freeman als Roger Chambers |
 | Destiny Brownridge als Maya |
 | Rob Morrow als Dr. Hollins |
 | Dawn Lewis als Flight Attendant |
 | Rowena King als Angelica |
| Annton Berry Jr. als Kai |
| Verda Bridges als Chandra |
 | Brian Copeland als Lee |
 | Ian Anthony Dale als Instructor |
| Jennifer Defrancisco als Emily |
 | Angela Gardner als Female Administrator |
 | Noel Gugliemi als Mechanic |
| Jonathan Hernandez als Manny |
 | Karen Maruyama als Nurse Shing |
| Amber Mead als Attractive Woman #1 |
| Serena Reeder als Rachel |
 | Christopher Stapleton als Kyle |
 | Taylor Ann Thompson als Edward's Granddaughter |
 | Alex Trebek als Self |
| John Schwartzman | Director of Photography |
| Janet Hirshenson | Casting |
| Rob Reiner | Director |
| Rob Reiner | Producer |
| Robert Leighton | Editor |
| Jane Jenkins | Casting |
| Robert Greenfield | Set Decoration |
| James E. Tocci | Set Designer |
| Jeffrey Stott | Executive Producer |
| Jeffrey Stott | Unit Production Manager |
| Marc Shaiman | Original Music Composer |
| Marc Fishman | Sound Re-Recording Mixer |
| Tony Lamberti | Sound Re-Recording Mixer |
| David Siegel | Unit Production Manager |
| Bryan Bowen | Sound Editor |
| Lon Bender | ADR Supervisor |
| Ian Fox | Camera Operator |
| Craig Zadan | Producer |
| Molly Maginnis | Costume Design |
| Valli O'Reilly | Makeup Department Head |
| Matthew W. Mungle | Prosthetic Makeup Artist |
| Alan Greisman | Producer |
| Neil Meron | Producer |
| Justin Zackham | Executive Producer |
| Justin Zackham | Writer |
| Travis Knox | Executive Producer |
| Bill Brzeski | Production Design |
| Frank Capra III | Co-Producer |
| Frank Capra III | First Assistant Director |
| Alex Daniels | Stunt Coordinator |
| Adam Scheinman | Additional Writing |
| Brian Relyea | Second Assistant Director |
| John R. Elliott | Construction Coordinator |
| Susan E. Novick | Post Production Supervisor |
| Scott Stambler | Music Editor |
| Tim Boggs | ADR Editor |
| Jamie Castro | Casting Assistant |
| Michael Germain | Makeup Artist |
| Jonathan A. Rosenfeld | Transportation Coordinator |
| Joy Zapata | Hairstylist |
| Sandy Kenyon | Costume Supervisor |
| Eugene McCarthy | Property Master |
| Kerry Lyn McKissick | Script Supervisor |
| Barbara Mesney | Set Designer |
| John C. Stuver | Dialogue Editor |
| Lori J. Nelson | Visual Effects Producer |
| Ann Scibelli | Sound Editor |
| Martha Johnston | Assistant Art Director |
| David R. Christensen | Chief Lighting Technician |
| Sidney Ray Baldwin | Still Photographer |
| Laura Harris Atkinson | Dialogue Editor |
| Rob Harris | Unit Publicist |
| Frank Dorowsky | Rigging Gaffer |
| Deena Adair | Hairstylist |
| Robbie Goldstein | Location Manager |
| Nancy Hancock | Makeup Artist |
| Gayle Wesley | First Assistant Sound Editor |
| Les T. Tomita | Key Grip |
| Jay Pelissier | Art Direction |
| Medusah | Hair Department Head |
| Marie Larkin | Key Hair Stylist |
| Donald Frazee | Special Effects Coordinator |
| Danny Miller | Assistant Editor |
| Mark Scoon | Executive In Charge Of Production |
| Ilana Gordon | Art Department Coordinator |
| Tonyia Verna | Key Makeup Artist |
| Jeff Verdick | Transportation Captain |
| Perry Dodgson | Boom Operator |
| Mo Henry | Negative Cutter |
| Corinne Villa | VFX Editor |
| Robert Eber | Production Sound Mixer |
| Mike Mesirow | Cableman |
| Sally Smith-McCardle | Key Costumer |
| John Cannon | Assistant Sound Editor |
| Eric Layne | Production Accountant |
| Jim Petti | Transportation Co-Captain |
| Mark Moretti | Storyboard |
| Mike Mertens | Color Timer |
