 | Forest Whitaker als Cecil Gaines |
 | Oprah Winfrey als Gloria Gaines |
 | David Oyelowo als Louis Gaines |
 | John Cusack als Richard Nixon |
 | Jane Fonda als Nancy Reagan |
 | Cuba Gooding Jr. als Carter Wilson |
 | Mariah Carey als Hattie Pearl |
 | Terrence Howard als Howard |
 | Lenny Kravitz als James Holloway |
 | Aml Ameen als Cecil Gaines (15) |
 | Michael Rainey Jr. als Cecil Gaines (8) |
 | James Marsden als John F. Kennedy |
 | Alex Pettyfer als Thomas Westfall |
 | Vanessa Redgrave als Annabeth Westfall |
 | Alan Rickman als Ronald Reagan |
 | Liev Schreiber als Lyndon B. Johnson |
 | Robin Williams als Dwight Eisenhower |
 | Yaya DaCosta als Carol Hammie |
 | David Banner als Earl Gaines |
 | Colman Domingo als Freddie Fallows |
 | Nelsan Ellis als Martin Luther King Jr. |
 | Nealla Gordon als Senator Kassebaum |
 | Elijah Kelley als Charlie Gaines (15-18) |
 | Minka Kelly als Jackie Kennedy |
 | Adriane Lenox als Gina |
 | Mo McRae als Eldridge Huggins |
 | Pernell Walker als Lorraine |
 | Jesse Williams als Rev. James Lawson |
 | Clarence Williams III als Maynard |
 | LaJessie Smith als Abraham |
| John P. Fertitta als Mr. Jenkins |
 | Jim Gleason als R.D. Warner |
 | Isaac White als Charlie Gaines (10) |
 | Joe Chrest als White Usher |
| Tyson Ford als Elroy |
 | James DuMont als Sherman Adams |
 | Robert Aberdeen als Herbert Brownell |
 | Olivia Washington als Olivia |
| Margaret M. Owens als Woolworth Diner Patron #1 |
| Eric Ducote als Woolworth Diner Patron #2 |
| Chloe Barach als Caroline Kennedy |
 | Danny Strong als Freedom Bus Journalist |
| Clara Hopkins Daniels als Freedom Bus Rider |
 | Dana Gourrier als Helen Holloway |
| Shirley Pugh als Malcolm X Goer |
| Bill Newman als Pastor |
 | Colin Walker als John Ehrlichman |
 | Alex Manette als Bob Haldeman |
| Rusty Robertson als Senator Robertson |
 | Stephen Rider als Admiral Rochon |
 | Tarra Riggs als Sophie Wilson (uncredited) |
 | Xosha Roquemore als Foxy (uncredited) |
| Lee Daniels | Director |
| Lee Daniels | Producer |
| Cassian Elwes | Producer |
| Buddy Patrick | Producer |
| Laura Ziskin | Producer |
| Andrew Dunn | Director of Photography |
| Danny Strong | Writer |
| Rodrigo Leão | Original Music Composer |
| Joe Klotz | Editor |
| Tim Galvin | Production Design |
| Jeff Galpin | Stunt Coordinator |
| Grayson Austin | Camera Operator |
| Jeffery J. Tufano | Camera Operator |
| Michael Stumpf | Additional Camera |
| Luis Lopez DeVictoria | Additional Camera |
| Anne Marie Fox | Still Photographer |
| Trey Shaneyfelt | Lighting Technician |
| Kristopher Weaver | Lighting Technician |
| Annette Farnsworth | Set Costumer |
| Ben Schor | Music Editor |
| Elizabeth Himelstein | Dialect Coach |
| Leah Daniels Butler | Casting |
| Billy Hopkins | Casting |
| Ruth E. Carter | Costume Design |
| Lori Agostino | Art Direction |
| Erik Polczwartek | Art Direction |
| Jason Baldwin Stewart | Art Direction |
| Diane Lederman | Set Decoration |
| Debra Denson | Makeup Department Head |
| Beverly Jo Pryor | Makeup Department Head |
| Deanna Simmons | Set Decoration Buyer |
| Kimberly Murphy | Set Decoration Buyer |
| Dana Kay Hart | Costume Supervisor |
| Wendy Talley | Costume Supervisor |
| Robert L. Stevenson | Hairstylist |
| Victoria Wood | Wigmaker |
| Jen Wall | Production Supervisor |
| Robin Simmerly | Art Department Coordinator |
| Sarah Forrest | Set Designer |
| Michelle C. Harmon | Set Designer |
| Brian A. Waits | Set Designer |
| Randall S. Coe | Construction Coordinator |
| Steve Martemucci | Construction Foreman |
| Michael Arena | Greensman |
| David Keith Broome | Greensman |
| John Lindsay | Greensman |
| Gus Coto | Leadman |
| Robert Hein | Supervising Sound Editor |
| Debby VanPoucke | Sound Designer |
| Robert Hein | Sound Re-Recording Mixer |
| Michael Barry | Sound Re-Recording Mixer |
| Daniel Cohen | Visual Effects Producer |
| Ted Markovic | Visual Effects Producer |
| Aniela Sidorska | Visual Effects Producer |
| Luke DiTommaso | Visual Effects Supervisor |
| Charlotta Forssman | Visual Effects Editor |
| Ray McIntyre Jr. | Visual Effects Supervisor |
| Ulysses Guidotti | First Assistant Editor |
| Kat Spiess | First Assistant Editor |
| Amy Sanderson | Script Supervisor |
| Virginia McCollam | Location Manager |
| Mickey Lambert | Location Manager |
| Harvey Weinstein | Executive Producer |
| Len Blavatnik | Executive Producer |
| Branka Mrkic | Supervising Dialogue Editor |
| David Wahnon | Dialogue Editor |
| Kevin Ladson | Property Master |
| Ruth Hernandez | ADR Editor |
| Heather Gross | Foley Editor |
| Lisa C. Satriano | First Assistant Director |
| Peter Dress | Second Assistant Director |
| Ari Daniel Pinchot | Producer |
| Bob Weinstein | Executive Producer |
| Marcos Gonzales | Additional Hairstylist |
| Daina Daigle | Assistant Hairstylist |
| Candace Neal | Hair Department Head |
| Dana Boisseau | Hairstylist |
| Sherri Hamilton | Hairstylist |
| Yolanda Sheridan | Key Makeup Artist |
| LeDiedra Richard-Baldwin | Makeup Artist |
| Kellie Robinson | Makeup Artist |
| Debra Denson | Makeup Designer |
| Matthew W. Mungle | Prosthetic Designer |
| Clinton Wayne | Prosthetic Designer |
| Courtney Lether | Prosthetic Makeup Artist |
| Jonah Levy | Special Effects Makeup Artist |
| Bradley Martin | Additional Lighting Technician |
| Zach Smithers | Additional Lighting Technician |
| Jordan Whaley | Additional Lighting Technician |
| Hans Bjerno | Aerial Director of Photography |
| Hilton Garrett | Best Boy Grip |
| Grayson Austin | Steadicam Operator |
| Francis James | Second Unit Director of Photography |
| Len Levine | Chief Lighting Technician |
| Damon Meledones | Digital Imaging Technician |
| Jeremy Webre | Dolly Grip |
| Robert D Morrison Jr. | Dolly Grip |
| Justin LeBlanc | Electrician |
| Justin Wright | Electrician |
| Richard Lacy | First Assistant Camera |
| Michael Charbonnet | First Assistant Camera |
| Tom Hutchinson | First Assistant Camera |
| Jason Prowell | Generator Operator |
| Dacoda Bartles | Grip |
| Kevin Fannon | Grip |
| Tyler Garrett | Grip |
| Jerone A. Ordon Sr. | Grip |
| Jeremy Wren | Grip |
| Andy Young | Grip |
| Sidney Brisco | Lighting Technician |
| Pete Chiaramonte | Lighting Technician |
| Carter Lee Garrett | Lighting Technician |
| Gerald Autin | Rigging Grip |
| Raúl J. Marín | Rigging Grip |
| Shawn Stone | Rigging Grip |
| Creig Symons | Rigging Grip |
| John Vinson | Rigging Grip |
| Ben Wachsmann | Rigging Grip |
| King Lanaux | Key Rigging Grip |
| Jonathan Robinson | Second Assistant Camera |
| Aeron McKeough | Second Assistant Camera |
| Josh Crouchet | Art Department Assistant |
| David Warburton | Assistant Property Master |
| Nicholas Ellerbee | Carpenter |
| Charlie Mann | Carpenter |
| Will Eastin | Graphic Designer |
| Roger Johnson | Graphic Designer |
| Spencer J. Abadie | Painter |
| Camile Kelsey | Painter |
| Daniel E. Kiker | Painter |
| Sonda L. Rowland | Painter |
| Sian C. Sanzone | Painter |
| Stephen Finders | Props |
| Iggie Colomer | Set Dresser |
| Michael Dares | Set Dresser |
| Stephen P. Durante | Set Dresser |
| Owl Martin Dwyer | Set Dresser |
| Sam Jacobs | Set Dresser |
| Jordan Lightner | Set Dresser |
| Tony Ziegler | Set Dresser |
| Ed Burcham | Set Dresser |
| Krissopher Chevannes | ADR Mixer |
| Jonathan Jost | ADR Mixer |
| Michael Miller | ADR Mixer |
| Tom Ryan | ADR Mixer |
| Billy Theriot | ADR Mixer |
| Fredrick Cuevas | ADR Recordist |
| John Jay Martyn | ADR Recordist |
| Reagan Mendoza | ADR Recordist |
| Dann Fink | ADR Voice Casting |
| Chris Fielder | Assistant Sound Editor |
| Alexa Zimmerman | Assistant Sound Editor |
| Michael Piotrowski | Boom Operator |
| James Eck Rippie | Boom Operator |
| Marko Costanzo | Foley Artist |
| Cariella Smith | Foley Artist |
| Matthew Haasch | Foley Supervisor |
| Dan Izen | Production Sound Mixer |
| Robert Fernandez | Sound Editor |
| Glenfield Payne | Sound Effects Editor |
| Avi Laniado | Sound Engineer |
| Jay Meagher | Sound Mixer |
| Steven Huerstel | Utility Sound |
| Mark Scott Friedman | Compositing Supervisor |
| Austin Meyers | Compositing Supervisor |
| Patrick Paul Mullane | Matte Painter |
| Bruce Winant | ADR Voice Casting |
| Kacee Devoe | Casting Associate |
| Ashley Ingram | Casting Associate |
| Christopher Stoudt | Extras Casting |
| Robin Batherson | Extras Casting Coordinator |
| Lesley D. Wickham | Ager/Dyer |
| Josie Works | Costume Assistant |
| Carmen Rodrigues Davis | Costume Coordinator |
| Chloe Ji Yoon | Costume Illustrator |
| Barbara Marko | Costumer |
| Misti Moreaux | Costumer |
| Mollie Middleditch | Costumer |
| Janet Marie Ross | Costumer |
| Kasey C. Bazil | Costumer |
| Paul A. Simmons Jr. | Key Costumer |
| Mustapha Mimis | Key Set Costumer |
| Jennifer Kamrath | Principal Costumer |
| Laura Faye Sirkin-Brown | Seamstress |
| Janet Marie Ross | Set Costumer |
| Melissa Reed | Truck Costumer |
| Rick Derby | Assistant Editor |
| Anne O'Brien | Assistant Editor |
| Christi Leftwich | Digital Intermediate Assistant |
| Ryan Rolandelli | Digital Intermediate Assistant |
| Tim Stipan | Digital Intermediate Colorist |
| Kevin Vale | Digital Intermediate Producer |
| Eric Horwitz | Digital Intermediate |
| Patrick Rossi | Digital Intermediate |
| Richie Roefaro | Editorial Staff |
| Suzana Peric | Music Editor |
| Lynn Fainchtein | Music Supervisor |
| Steve Bartek | Music Arranger |
| Randall Balsmeyer | Title Designer |
| Jason Frannino | Animal Wrangler |
| Jeff Galpin | Animal Wrangler |
| Edward Joubert | Special Effects Technician |
| Jake Whitney | Special Effects Technician |
| David K. Nami | Special Effects Coordinator |
| Eric Leverenz | Online Editor |
| Thom Jones | Dialect Coach |
| Ryan Gomez | First Assistant Accountant |
| Mike Revell | Production Accountant |
| Davida Chanel Smith | Producer's Assistant |
| Lauren Von Huene | Production Coordinator |
| Carl Lawson | Production Secretary |
| Chantel Passantino | Second Assistant Accountant |
| Danielle Loosemore | Second Assistant Accountant |
| Ashley Renee Saunders | Travel Coordinator |
| Sebastián Silva | Second Unit Director |
| Danny Epper | Stunts |
| Meredith Richardson | Stunts |
