 | Jennifer Lopez als Catherine Deane |
 | Vince Vaughn als Peter Novak |
 | Vincent D'Onofrio als Carl Rudolph Stargher |
 | Catherine Sutherland als Anne Marie Vicksey |
 | James Gammon als Teddy Lee |
 | Colton James als Edward Baines |
 | Dylan Baker als Henry West |
 | Marianne Jean-Baptiste als Dr. Miriam Kent |
 | Gerry Becker als Dr. Barry Cooperman |
 | Musetta Vander als Ella Baines |
 | Patrick Bauchau als Lucien Baines |
 | Jake Weber als Gordon Ramsey |
 | Dean Norris als Cole |
 | Tara Subkoff als Julia Hickson |
 | Lauri Johnson als Mrs. Hickson |
 | John Cothran als Agent Stockwell |
 | Jack Conley als Agent Brock |
 | Kamar de los Reyes als Officer Alexander |
 | Pruitt Taylor Vince als Dr. Reid |
 | Peter Sarsgaard als Julia Hickson's Fiancee (uncredited) |
 | Christopher Janney als Swat Team Member |
| Nicholas Cascone als FBI Technician |
| Joe La Piana als FBI K-9 Agent |
 | Jake Thomas als Young Carl Stargher |
| Kim Chizevsky-Nicholls als Stargher's Victim |
| Jennifer Day als Stargher's Victim |
 | Alanna Vicente als Stargher's Victim |
| Aja Echols als Stargher's Victim |
 | Vanessa Branch als Stargher's Victim |
| Elena Maddalo als Stargher's Victim |
 | Gareth Williams als Stargher's Father |
 | Monica Lacy als Mother |
 | Joy Creel als Mother |
 | Leanna Creel als Mother |
 | Alan D. Purwin als Helicopter Pilot |
| Tom Foden | Production Design |
| Julio Caro | Producer |
| Carolyn Manetti | Executive Producer |
| Eiko Ishioka | Costume Design |
| Eric McLeod | Producer |
| Howard Shore | Original Music Composer |
| Robert Duffy | Editor |
| Paul Rubell | Editor |
| Ronna Kress | Casting |
| Mark Protosevich | Screenplay |
| Tarsem Singh | Director |
| Donna Langley | Executive Producer |
| Paul Laufer | Director of Photography |
| April Napier | Costume Design |
| Luke Freeborn | Set Designer |
| Steve Callas | Construction Coordinator |
| Kent Jones | Sculptor |
| Jann Baskett | Visual Effects |
| Dean Wolcott | Set Designer |
| Josh Lusby | Set Designer |
| Dawn M. Severdia | Art Department Coordinator |
| Francesco Grisi | Visual Effects |
| Linda Matthews | Costume Supervisor |
| Suzana Peric | Music Editor |
| Tessa Posnansky | Set Decoration |
| Camille Calvet | Makeup Artist |
| Michael Manson | Art Direction |
| Kevin Tod Haug | Visual Effects Supervisor |
| Geoff Hubbard | Supervising Art Director |
| Susan Germaine | Hairstylist |
| Guy Hendrix Dyas | Assistant Art Director |
| Alex L. Worman | Unit Publicist |
| Katherine E. Beyda | Production Supervisor |
| John Roesch | Foley |
| Kevin E. Carpenter | Sound Re-Recording Mixer |
| Laura Baker | Set Costumer |
| Jonathan Bobbitt | Leadman |
| Michael Herbick | Sound Re-Recording Mixer |
| Dennis Berardi | Visual Effects Supervisor |
| Anthony Gaudioz | Camera Operator |
| Erwin H. Kupitz | Wigmaker |
| Joshua Hancock | Picture Car Coordinator |
| Paul Huntley | Wigmaker |
| Judi Townsend | Script Supervisor |
| Rick Matthews | Location Manager |
| Tommy Turtle | Production Supervisor |
| J. Paul Huntsman | Supervising Sound Editor |
| Adam Johnston | Sound Designer |
| Robert J. Litt | Sound Re-Recording Mixer |
| Thomas Nead | Rigging Gaffer |
| Scott R. Hankins | Set Costumer |
| Bill M. Puluti | Transportation Coordinator |
| Renate Leuschner | Wigmaker |
| Lorey Sebastian | Still Photographer |
| Thomas Whiting | ADR & Dubbing |
| Alyson Dee Moore | Foley |
| Jayme S. Parker | Sound Designer |
| Will Robbins | CG Supervisor |
| Jack Gill | Stunt Coordinator |
| Michèle Burke | Makeup Artist |
| Brad Einhorn | Property Master |
| Patrick J. Foley | Dialogue Editor |
| Heather Plott | Assistant Makeup Artist |
| Susan Germaine | Hair Supervisor |
| Candace Neal | Key Hair Stylist |
| Edouard F. Henriques | Key Makeup Artist |
| Michael Amundson | First Assistant Director |
| Frederic Roth | Second Assistant Director |
| Eliza Steel | Art Department Production Assistant |
| Jim Wojtowicz | Art Department Production Assistant |
| Andrew M. Siegel | Assistant Property Master |
| Edwin Roses | Graphic Designer |
| Michael MacFarlane | Painter |
| Kevin Wasner | Prop Maker |
| Chris Fix | Prop Maker |
| Bart Barbuscia | Set Dresser |
| Skip Crank | Set Dresser |
| Kris Fuller | Set Dresser |
| Louis Terry | Set Dresser |
| Jesse Siono Jr. | Standby Painter |
| Trevor Goring | Storyboard Artist |
| David B. Nowell | Aerial Camera |
| Robert White | Best Boy Electrician |
| Robena Malicoat | Best Boy Grip |
| J. Wayne Parker | Best Boy Grip |
| Katie Santore | Camera Loader |
| George Ball | Chief Lighting Technician |
| C. Ashley Sudge | Dolly Grip |
| Donald Burghardt | First Assistant "A" Camera |
| C. Alan Rawlins Sr. | Key Grip |
| Bob Leitelt | Key Rigging Grip |
| Chris Culliton | Lighting Technician |
| Khan Griffith | Lighting Technician |
| Brad M. Hazen | Lighting Technician |
| Steven R. Morales | Lighting Technician |
| Tony Boura | Rigging Grip |
| Ster Percy | Rigging Grip |
| Arthur Najera | Rigging Grip |
| Bertoldo Gomez | Rigging Grip |
| Brett F. Gates | Second Assistant "A" Camera |
| David Drzewiecki | Second Unit Director of Photography |
| Sande Alessi | Extras Casting |
| Jackie Caro | Costumer |
| William A. Campbell | Key Costumer |
| Wendy M. Craig | Key Set Costumer |
| Francine Lecoultre | Textile Artist |
| Dana Kristen Vahle | Pilot |
| Kristy Blackwell | 3D Animator |
| Colin Cunningham | 3D Animator |
| Raymond Gieringer | 3D Animator |
| Lon Molnar | 3D Animator |
| Xavier Allard | Animation |
| Olivier Cauwet | Animation |
| Nicolas Darques | Animation |
| Antoine Deschamps | Animation |
| Guillaume Ha | Animation |
| Vincent Thomas | Animation |
| François Boudaille | Animation |
| David Drzewiecki | VFX Director of Photography |
| Roger Sassen | Gaffer |
| Christophe Dupuis | Lead Animator |
| Laurent Gillet | Lead Animator |
| Stephane Naze | Lead Animator |
| Geoffrey Niquet | Lead Animator |
| Dominique Vidal | Lead Animator |
| Colin Green | Pre-Visualization Supervisor |
| Jeff Campbell | Visual Effects Compositor |
| Rob Gyorgy | Visual Effects Compositor |
| Max Harris | Visual Effects Compositor |
| Michael Hatton | Visual Effects Compositor |
| Tania Janthur | Visual Effects Coordinator |
| Carey Len Smith | Visual Effects Coordinator |
| Alex Boothby | Visual Effects Designer |
| Katherine Jones | Visual Effects |
| Brad Phillips | Visual Effects |
| Dick Ziker | Stunts |
| Cinda-Lin James | Stunt Double |
| Andy Gill | Stunts |
| Manny Perry | Stunts |
| John C. Meier | Stunts |
| Jill Brown | Stunt Double |
| Michael Runyard | Stunts |
| Kenny Endoso | Stunts |
| Sandy Berumen | Stunts |
| Joe Bucaro III | Stunts |
| Pat Romano | Stunts |
