 | Ross Bagdasarian, Jr. als David Seville / Alvin Seville / Simon Seville (voice) |
 | Janice Karman als Theodore Seville / Brittany Miller / Jeanette Miller / Eleanor Miller |
 | Dody Goodman als Miss Rebecca Miller (voice) |
 | Susan Tyrrell als Claudia Furschtien (voice) |
 | Anthony De Longis als Klaus Furschtien (voice) |
 | Frank Welker als Sophie / Native Chief / Baby Penguin / Additional Voices (voice) |
 | Nancy Cartwright als Arabian Prince (voice) |
 | Philip L. Clarke als Additional Voices (voice) |
 | Ken Sansom als Inspector Jamal (voice) |
 | George Poulos als Additional Voices (voice) |
 | Charlie Adler als Additional Voices (voice) |
 | Patrick Pinney als Additional Voices (voice) |
 | Jack Angel als Additional Voices (voice; uncredited) |
 | Mel Blanc als Additional Voices (voice; uncredited) |
 | Laura Summer als Additional Voices (voice; uncredited) |
| Janice Karman | Director |
| Tim Allen | Animation |
| Al Holter | Animation |
| John Williamson | Animation |
| Rob Bekuhrs | Visual Effects |
| Janice Karman | Writer |
| Ross Bagdasarian | Characters |
| Ross Bagdasarian, Jr. | Writer |
| Ross Bagdasarian, Jr. | Producer |
| Michael Wolf | Production Manager |
| Rocky Solotoff | Production Supervisor |
| Sam Horta | Sound Editor |
| Scott D. Jackson | Sound Editor |
| Gary Krivacek | Sound Editor |
| Cecil Broughton | Sound Editor |
| Jeffrey J. Haboush | Sound Re-Recording Mixer |
| Donald W. Ernst | Supervising Sound Editor |
| Greg P. Russell | Sound Re-Recording Mixer |
| Kathleen Quaife-Hodge | Supervising Animation Director |
| Greg Griffin | Assistant Editor |
| Rick Riccobono | Music Supervisor |
| Douglas M. Lackey | Music Editor |
| Ralph Ferraro | Orchestrator |
| Rob Matheny | Music Supervisor |
| Randy Edelman | Music Arranger |
| Howard Pfeifer | Music Arranger |
| Roxy Steven | Production Coordinator |
| Patty Burns | Production Coordinator |
| Andrew Gaskill | Title Designer |
| Hope London | Production Executive |
| Ollie Johnston | Thanks |
| Frank Thomas | Thanks |
| Louise Zingarelli | Casting |
| Tony Mizgalski | Editor |
| Randy Edelman | Music |
| Steven Hahn | Co-Producer |
| Sue Shakespeare | Associate Producer |
| Carol Holman Grosvenor | Production Design |
| Skip Jones | Animation Director |
| Alan Smart | Animation |
