 | Tobey Maguire als Homer Wells |
 | Charlize Theron als Candy Kendall |
 | Delroy Lindo als Arthur Rose |
 | Paul Rudd als Lt. Wally Worthington |
 | Michael Caine als Dr. Wilbur Larch |
 | Jane Alexander als Nurse Edna |
 | Kathy Baker als Nurse Angela |
 | Erykah Badu als Rose Rose |
 | Kieran Culkin als Buster |
 | Kate Nelligan als Olive Worthington |
 | Heavy D als Peaches |
 | J.K. Simmons als Ray Kendall |
 | Erik Per Sullivan als Fuzzy |
 | Paz de la Huerta als Mary Agnes |
 | K. Todd Freeman als Muddy |
 | Evan Parke als Jack |
 | Jimmy Flynn als Vernon |
 | Lonnie Farmer als Hero |
| Spencer Diamond als Curly |
 | Skye McCole Bartusiak als Hazel |
| Sean Andrew als Copperfield |
| John Albano als Steerforth |
| Claire Daly als Clara |
| Colin Irving als Major Winslow |
 | Annie Corley als Carla |
| Patrick Donnelly als Adopting Father |
| Edie Schechter als Adopting Mother |
| Kasey Berry als 12yr. Old Girl |
| Mary Bogue als Big Dot |
| Victoria Stankiewicz als Debra |
| Christine Stevens als Florence |
| Earle C. Batchelder als Dr. Holtz |
| Norma Fine als Mrs. Goodhall |
 | John Irving als Stationmaster |
 | Eric Bruno Borgman als Flirting Soldier on Train (uncredited) |
 | Kevin Chapman als Adopting Dad (uncredited) |
 | John H. Tobin als Man on Train (uncredited) |
| John Irving | Novel |
| Alan C. Blomquist | Producer |
| Brenda McNally | Hairstylist |
| Barbara A. Hall | Unit Production Manager |
| Katia Milani | Post Production Supervisor |
| Peggy Schierholz | Hairstylist |
| David Gropman | Production Design |
| Bob Weinstein | Executive Producer |
| Oliver Stapleton | Director of Photography |
| Ellie Winslow | Makeup Artist |
| John Irving | Screenplay |
| Sharyn Cordice | Makeup Artist |
| Kerry Barden | Casting |
| Suzanne Smith Crowley | Casting |
| Diana Zock | Production Supervisor |
| Leslie Holleran | Producer |
| Lasse Hallström | Director |
| Karen Schulz Gropman | Art Direction |
| Billy Hopkins | Casting |
| Beth A. Rubino | Set Decoration |
| Renee Ehrlich Kalfus | Costume Design |
| Harvey Weinstein | Executive Producer |
| Bobby Cohen | Executive Producer |
| Lila Yacoub | Producer |
| Rachel Portman | Music |
| Richard N. Gladstein | Producer |
| Meryl Poster | Executive Producer |
| Lisa Zeno Churgin | Editor |
| Wylie Griffin | Art Department Coordinator |
| Jane Goldsmith | Script Supervisor |
| Ron Bolanowski | Special Effects Coordinator |
| Michele Platt | Associate Producer |
| Charles Croughwell | Stunt Coordinator |
| Denney Pierce | Utility Stunts |
| Wayne Herndon | Hairstylist |
| Deborah K. Larsen | Makeup Artist |
| Louie Zakarian | Makeup Artist |
| Stephen P. Dunn | First Assistant Director |
| Paul Byrne Prenderville | Second Second Assistant Director |
| Christina Stauffer | Second Assistant Director |
| Paul Byrne Prenderville | First Assistant Director |
| Robert Bolanowski | Special Effects |
| Gina Alfano | Supervising ADR Editor |
| David Boulton | ADR Mixer |
| Bob Chefalas | Sound Re-Recording Mixer |
| Richard P. Cirincione | Sound Effects Editor |
| Laura Civiello | Supervising Dialogue Editor |
| Joe Dohner | Foley Mixer |
| Louis Bertini | Foley Editor |
| Petur Hliddal | Production Sound Mixer |
| Bruce Kitzmeyer | Foley Editor |
| Dan Korintus | Dialogue Editor |
| Jasmine Kosovic | ADR Coordinator |
| Marissa Littlefield | ADR Editor |
| Joshua Landis | Assistant Sound Editor |
| Eytan Mirsky | Sound Effects Editor |
| Frank Morrone | Sound Re-Recording Mixer |
| Bitty O'Sullivan-Smith | Dialogue Editor |
| Bob Olari | Sound Recordist |
| Harry Peck Bolles | ADR Editor |
| Steve Pederson | Sound Re-Recording Mixer |
| Tom Perry | Sound Re-Recording Mixer |
| Alex Raspa | ADR Recordist |
| Jacob Ribicoff | Foley Editor |
| Maurice Schell | Supervising Sound Editor |
| Dominick Tavella | Sound Re-Recording Mixer |
| Brian Vancho | Foley Artist |
| Magdaline Volaitis | Dialogue Editor |
| Peter Waggoner | Sound Re-Recording Mixer |
| Ant Bohun | ADR Recordist |
| Phillip Fuller | Sound Mix Technician |
| Phil Hadaway | ADR Engineer |
| Scott Jones | ADR Mixer |
| William Morts | Utility Stunts |
| Zachary K. Lazar | Lighting Technician |
