 | Seth Rogen als Andy Brewster |
 | Barbra Streisand als Joyce Brewster |
 | Yvonne Strahovski als Jessica |
 | Colin Hanks als Rob |
 | Brett Cullen als Ben |
 | Adam Scott als Andrew Margolis Jr. |
 | Ari Graynor als Joyce Margolis |
 | Kathy Najimy als Gayle |
 | Danny Pudi als Sanjay |
 | Casey Wilson als Amanda |
 | Dale Dickey als Tammy |
 | Michael Cassidy als Fake Andy |
 | Brandon Keener als Ryan Mcfee |
 | Robert Curtis Brown als Bob Ferguson |
 | Nora Dunn als Amy |
 | Miriam Margolyes als Anita |
 | Rose Abdoo als Diana |
 | Analeis Lorig als Moonlight |
 | Gabrielle Gumbs als Stripper |
 | Rick Gonzalez als Mark |
 | Worth Howe als Bob |
 | Vicki Goldsmith als Young Joyce |
 | Constance Esposito als HSN Executive |
 | Creed Bratton als Suitor |
 | Jeff Kober als Jimmy |
 | Tom Virtue als Mature Singles Man |
| David Lazan | Art Direction |
| Priscilla Nedd-Friendly | Editor |
| Amanda Mackey | Casting |
| Cathy Sandrich Gelfond | Casting |
| Nelson Coates | Production Design |
| Danny Glicker | Costume Design |
| Karen O'Hara | Set Decoration |
| Barbra Streisand | Executive Producer |
| Dino DiMuro | Sound Designer |
| Andy Potvin | Dolby Consultant |
| Anne Fletcher | Director |
| Dan Fogelman | Screenplay |
| Dan Fogelman | Executive Producer |
| Christopher Assells | Sound Designer |
| Oliver Stapleton | Director of Photography |
| Greg P. Russell | Sound Re-Recording Mixer |
| Seth Rogen | Executive Producer |
| Christophe Beck | Original Music Composer |
| John Goldwyn | Producer |
| Chris Palermo | Stunt Driver |
| Dana E. Glauberman | Editor |
| Buck Damon | Music Supervisor |
| Evan Goldberg | Producer |
| Evan Goldberg | Executive Producer |
| Lorne Michaels | Producer |
| Scott Curtis | Foley Mixer |
| Mike Moyer | Chief Lighting Technician |
| Mary McLaglen | Executive Producer |
| Terry Baliel | Hair Department Head |
| James Weaver | Co-Producer |
| Erin Doyle | Associate Producer |
| Debbie Evans | Stunt Driver |
| Lisa Layman | Makeup Department Head |
| Amy Schmiederer | Key Makeup Artist |
| Julie Hewett | Makeup Artist |
| Scott Millan | Sound Re-Recording Mixer |
| George Chavez | Color Timer |
| Kerry Lyn McKissick | Script Supervisor |
| Darrin Prescott | Second Unit Director |
| Julie Feiner | ADR Editor |
| Melissa Muik | Music Editor |
| Karen Vassar Triest | Sound Effects Editor |
| Sam Emerson | Still Photographer |
| John C. Stuver | Dialogue Editor |
| Hope M. Parrish | Property Master |
| Mary Ann Valdes | Hairstylist |
| Michele K. Short | Assistant Costume Designer |
| Tommy Tancharoen | Transportation Coordinator |
| Karen Baker Landers | Supervising Sound Editor |
| Peter Staubli | Sound Effects Editor |
| Chris Hogan | Dialogue Editor |
| Dan Hegeman | Sound Effects Editor |
| Chris Jargo | Supervising ADR Editor |
| Mark R. Byers | Special Effects Coordinator |
| Carol McConnaughey | Unit Publicist |
| Katrina Chevalier | Key Hair Stylist |
| Eric Hooge | Location Manager |
| Beth O'Rourke | Makeup Artist |
| Kathleen Walker | Art Department Coordinator |
| Suzanne Cranfill | Costume Supervisor |
| Peter J. Devlin | Sound Mixer |
| Thomas Whelpley | Transportation Captain |
| Kevin Hyde | Boom Operator |
| Craig S. Jaeger | Foley Supervisor |
| Terrence Martin | Production Coordinator |
| Darrin Mann | Foley Mixer |
| Jayne Armstrong | Post Production Supervisor |
| Gretel Twombly | Production Supervisor |
| Joel Prihoda | Leadman |
| Frank Yario Jr. | Video Assist Operator |
| Joanne Lamstein | Stunt Double |
| Hilary Marx | Co-Producer |
| Eric Mancha | VFX Artist |
