 | Bradley Cooper als Phil Wenneck |
 | Ed Helms als Stu Price |
 | Zach Galifianakis als Alan Garner |
 | Justin Bartha als Doug Billings |
 | Heather Graham als Jade |
 | Sasha Barrese als Tracy Garner |
 | Jeffrey Tambor als Sid Garner |
 | Ken Jeong als Mr. Chow |
 | Rachael Harris als Melissa |
 | Mike Tyson als Mike Tyson |
 | Mike Epps als Black Doug |
 | Jernard Burks als Leonard |
 | Rob Riggle als Officer Franklin |
 | Cleo King als Officer Garden |
 | Bryan Callen als Eddie Palermo |
 | Matt Walsh als Dr. Valsh |
 | Ian Anthony Dale als Chow's #1 |
 | Michael Li als Chow's #2 |
 | Sondra Currie als Linda |
 | Gillian Vigman als Stephanie |
| Nathalie Fay als Lisa |
 | Chuck Pacheco als Hotel Guest at Valet |
 | Jesse Erwin als Hotel Valet |
 | Dan Finnerty als Wedding Singer |
| Keith Lyle als Casino Dealer |
 | Brody Stevens als Officer Foltz |
 | Todd Phillips als Mr. Creepy |
 | Mike Vallely als Neeco |
 | James Martin Kelly als Police Clerk |
| Murray Gershenz als Felix |
 | Andrew Astor als Eli |
| Casey Margolis als Budnick |
| Ken Flaherty als Old Timer at Gas Station |
| Joe Alexander als Pit Boss |
| Constance Broge als Woman in Elevator |
| Sue Pierce als Mini-Mart Cashier |
 | Floyd Levine als Tailor |
| Robert A. Ringler als Minister |
| Britt Barrett als Bridesmaid |
 | Chauntae Davies als Bridesmaid |
 | Alisa Allapach als Bridesmaid |
| Nicholas Furu als Stun Gun Boy |
 | Angelica Flameno als Stun Gun Girl |
| Lily Winn als Screaming Girl |
 | Katerina Moutsatsou als Eddie's Assistant |
| Faleolo Alailima als Tyson's Bodyguard |
| Rio Ahn als Orderly (uncredited) |
| Joey Brander als Student (uncredited) |
| John Jason Bailey als Caesar's Palace Pimp (uncredited) |
 | Cody Deal als Roman Soldier at Caesar's Palace (uncredited) |
 | Natalie Cohen als Casino Guest (uncredited) |
 | Carrie Keagan als Casino Guest (uncredited) |
| Stephanie Mathis als Casino Guest (uncredited) |
 | Guile Branco als Casino Guest (uncredited) |
 | Richard Alan Reid als Casino High Roller (uncredited) |
| Tom Spano als Casino High Roller (uncredited) |
| Lanette Fugit Hannah als High Roller (uncredited) |
 | David Hill als Parent Driving Jaguar (uncredited) |
 | Mitch Holleman als Max - Student (uncredited) |
| Jessica Simons als Casino Guest (uncredited) |
| Anthony Mingilino als Precision Driver (uncredited) |
| Michael A. Rizza als Guy in the Elevator (uncredited) |
| Charlene Geisler als Katie / Girl in the Elevator (uncredited) |
| Kaitlin Clark als Girl in Elevator (uncredited) |
 | Heather Roop als Mom in Elevator (uncredited) |
 | Joe Satriani als Guitarist in Wedding Band (uncredited) |
 | Carrot Top als Himself (uncredited) |
| Jaira Valenti als Bartender Hostess (uncredited) |
| Anat Gerber als Cocktail Waitress (uncredited) |
 | Victor Yerrid als Tiger (uncredited) |
| Christophe Beck | Original Music Composer |
| Chris Bender | Executive Producer |
| William Fay | Executive Producer |
| Todd Phillips | Director |
| Daniel Goldberg | Producer |
| Lawrence Sher | Director of Photography |
| Todd Phillips | Producer |
| Debra Neil-Fisher | Editor |
| Seth Yanklewitz | Casting |
| Scott Budnick | Executive Producer |
| Jon Jashni | Executive Producer |
| Thomas Tull | Executive Producer |
| Jon Lucas | Screenplay |
| Bill Brzeski | Production Design |
| J.C. Spink | Executive Producer |
| Scott Moore | Screenplay |
| Juel Bestrop | Casting |
| Russell Bobbitt | Property Master |
| Louise Mingenbach | Costume Design |
| George Drakoulias | Music Supervisor |
| Randall Poster | Music Supervisor |
| David Siegel | Co-Producer |
| Jeffrey Wetzel | Co-Producer |
| David Siegel | Unit Production Manager |
| Jeffrey Wetzel | First Assistant Director |
| Paul Schneider | Second Assistant Director |
| Andrew Max Cahn | Supervising Art Director |
| A. Todd Holland | Art Direction |
| Danielle Berman | Set Decoration |
| Daniel C. Gold | "A" Camera Operator |
| Julie Donovan | First Assistant "A" Camera |
| Bryan G. Haigh | Second Assistant "A" Camera |
| Geoffrey Haley | "B" Camera Operator |
| Geoffrey Haley | Steadicam Operator |
| Gregory Irwin | First Assistant "B" Camera |
| Jerry Patton | Second Assistant "B" Camera |
| Suzanne Dietz | Camera Loader |
| Alan Caudillo | Second Unit Director of Photography |
| Michael Kelem | Aerial Director of Photography |
| Lee Orloff | Sound Mixer |
| Brian Robinson | Boom Operator |
| Mike Anderson | Utility Sound |
| Kerry Lyn McKissick | Script Supervisor |
| Jarred Waldron | Chief Lighting Technician |
| David Ghegan | Assistant Chief Lighting Technician |
| Sean Patrick Crowell | Key Grip |
| John Koth | Best Boy Grip |
| Josh Stancil | Key Rigging Grip |
| Seong Dilg | Dolly Grip |
| Janeen Schreyer | Makeup Department Head |
| Patricia Androff | Key Makeup Artist |
| Lori McCoy-Bell | Hair Department Head |
| Merribelle Anderson | Key Hair Stylist |
| Alison McCosh | Assistant Costume Designer |
| Charlene Amateau | Costume Supervisor |
| Mitchell Ray Kenney | Costume Supervisor |
| Susan E. Novick | Post Production Supervisor |
| David S. Clark | First Assistant Editor |
| Andrew Silver | Supervising Music Editor |
| Fernand Bos | Music Editor |
| Julie Pearce | Music Editor |
| Tim Chau | Sound Designer |
| Tim Chau | Supervising Sound Editor |
| Tim Chau | Sound Re-Recording Mixer |
| Gregory H. Watkins | Sound Re-Recording Mixer |
| Tim LeBlanc | Sound Re-Recording Mixer |
| Jim Brookshire | Supervising ADR Editor |
| Nils C. Jensen | Sound Effects Editor |
| Clayton Weber | Sound Effects Editor |
| Bob Beher | Foley Editor |
| Benjamin Beardwood | Dialogue Editor |
| Joseph Tsai | Assistant Sound Editor |
| John Roesch | Foley Artist |
| Alyson Dee Moore | Foley Artist |
| David Lee Fein | Foley Artist |
| Hilda Hodges | Foley Artist |
| Mary Jo Lang | Foley Mixer |
| David Jobe | Foley Mixer |
| Thomas J. O'Connell | ADR Mixer |
| Gretel Twombly | Production Coordinator |
| Ken Lavet | Location Manager |
| Desma Murphy | Assistant Art Director |
| R. Scott Doran | Leadman |
| Ted Boonthanakit | Storyboard Artist |
| Christopher Isenegger | Art Department Coordinator |
| Frank Masi | Still Photographer |
| Gray Marshall | Visual Effects Supervisor |
| Kevin O'Neil | Second Second Assistant Director |
| Courtenay Miles | Second Unit First Assistant Director |
| David Mendoza | Additional Second Assistant Director |
| David Leitch | Stunts |
| Jon H. Epstein | Utility Stunts |
| Freddie Hice | Stunts |
| Chris Palermo | Stunts |
| Darrin Prescott | Stunt Coordinator |
| Scotty Richards | Stunt Coordinator |
| Michael H. Barnett | Stunts |
| Philip Tan | Stunts |
| Casey O'Neill | Stunts |
| Craig Frosty Silva | Stunts |
| Ed McDermott II | Stunt Driver |
| Chris O'Hara | Stunts |
| Mickey Giacomazzi | Stunts |
| Sean Graham | Stunts |
| Wade Eastwood | Stunt Driver |
| Mike Justus | Utility Stunts |
| Donny Bailey | Stunt Driver |
| Thomas Robinson Harper | Stunts |
| Keith Woulard | Stunts |
| Sonny Tipton | Stunt Double |
| Mark Norby | Stunt Double |
| Philip Tan | Stunt Double |
| Suzanne Prescott | Stunts |
| Jimmy Hart | Stunts |
| Robert Nagle | Stunt Driver |
| Marc C. Geschwind | Stunt Driver |
