 | Melissa McCarthy als Detective Connie Edwards |
 | Bill Barretta als Phil Philips / Junkyard / Boar |
 | Elizabeth Banks als Jenny |
 | Joel McHale als Agent Campbell |
 | Maya Rudolph als Bubbles |
 | Leslie David Baker als Lt. Banning |
 | Cynthy Wu als Brittenie Marlowe |
 | Michael McDonald als Ronovan Scargle |
 | Mitch Silpa als Tommy |
 | Hemky Madera als Tito |
 | Benjamin Royer als Rick |
 | Brekkan Spens als Dick |
 | Ryan Tran als Phil |
 | Fortune Feimster als Robin |
 | Brian Palermo als Paramedic |
 | Damon Jones als Police Station Guard John / Puppet Doctor |
 | Ryan Gaul als Officer Milligan |
 | Jimmy O. Yang als Officer Delancey |
 | Dennis Keiffer als Junior |
 | Jim Palmer als Caesar |
 | Michael Croner als Jack Cook |
 | Barry Rothbart als Fireman |
| Steve Mallory als Kerry |
 | Dana Schick als Pretty Girl |
 | Jaye Razor als Razor |
 | Jen Sung als Sandra's Bodyguard |
| Bryan Cartago als Sandra's Bodyguard |
 | Brett Wagner als Rio |
 | Colleen Smith als Carol / Dalmatian / Cara |
 | Ben Falcone als Donny |
| Dorien Davies als Sandra |
 | Kevin Clash als Bumblypants / Lyle |
 | Victor Yerrid als Larry / Old Man Puppet |
 | Drew Massey als Goofer / Vinny |
 | Ted Michaels als Sexist Thug / Ezra |
 | Brian Henson als Crab |
 | Patty Guggenheim als Roxy |
 | Donna Kimball als Roxy / Cow / Rotten Cotton Girl |
 | Alice Dinnean als Rotten Cotton Girl |
 | Allan Trautman als Octopus / Puppet Doctor |
| Brian Henson | Director |
| Mitchell Amundsen | Director of Photography |
| Todd Berger | Screenplay |
| Dee Robertson | Story |
| Todd Berger | Story |
| Ben Falcone | Producer |
| Jeffrey M. Hayes | Producer |
| Brian Henson | Producer |
| Melissa McCarthy | Producer |
| Brian Scott Olds | Editor |
| Chris L. Spellman | Production Design |
| Arjun Bhasin | Costume Design |
| Gabriella Pollino | Hair Department Head |
| Gigi Williams | Makeup Department Head |
| George H. Anderson | Sound Designer |
| Jim Stuebe | Sound Mixer |
| John W. Hyde | Executive Producer |
| Robert Simonds | Executive Producer |
| Adam Fogelson | Executive Producer |
| Wang Zhongjun | Executive Producer |
| Wang Zhonglei | Executive Producer |
| Felice Bee | Executive Producer |
| Teddy Schwarzman | Executive Producer |
| Ben Stillman | Executive Producer |
| Michael Heimler | Executive Producer |
| Lisa Henson | Executive Producer |
| Dee Robertson | Executive Producer |
| Donald Tang | Executive Producer |
| Christopher Lennertz | Original Music Composer |
| Jason Markey | Music Supervisor |
| Vincent J. Raisa | Co-Producer |
| Basil Grillo | Co-Producer |
| Divya D'Souza | Co-Producer |
| Jeanne McCarthy | Casting |
| Nicole Abellara Hallman | Casting |
| Charles Rapp | Unit Production Manager |
| Basil Grillo | Unit Production Manager |
| Daniel Silverberg | First Assistant Director |
| Lisa Bloch-Tobey | Second Assistant Director |
| Sam Nicholson | Visual Effects Supervisor |
| Melissa Brockman | Visual Effects Producer |
| Walter Garcia | Stunt Coordinator |
| Luci Romberg | Stunt Coordinator |
| Alex Rockwell | Associate Producer |
| Christopher Burian-Mohr | Art Direction |
| Kelly Berry | Set Decoration |
| Jane Goldsmith | Script Supervisor |
| Paula Truman | Costume Supervisor |
| Michelle Audrina Kim | Makeup Artist |
| Ma Kalaadevi Ananda | Makeup Artist |
| Melanie Hughes | Makeup Artist |
| Philip Toolin | Set Designer |
| Geoff Hubbard | Set Designer |
| Tammy Fearing | Supervising Sound Editor |
| Marc Fishman | Sound Re-Recording Mixer |
| Andy Hay | Sound Re-Recording Mixer |
| Jeffrey M. Hayes | Second Unit Director |
| Randall Rosa | Visual Effects Supervisor |
| Bryan Binder | Visual Effects Producer |
| Jess Brown | Visual Effects Producer |
| Tyler Foell | Visual Effects Producer |
| Tony Pirzadeh | Visual Effects Producer |
| Lauren Mary Kim | Stunt Double |
| Heidi Pascoe | Stunt Double |
| Hannah Betts | Stunts |
| Joey Box | Stunt Coordinator |
