 | Martin Freeman als Arthur Dent |
 | Yasiin Bey als Ford Prefect |
 | Zooey Deschanel als Trillian |
 | Sam Rockwell als Zaphod Beeblebrox |
 | Alan Rickman als Marvin (voice) |
 | Anna Chancellor als Questular Rontok |
 | Bill Nighy als Slartibartfast |
 | Richard Griffiths als Jeltz (voice) |
 | John Malkovich als Humma Kavula |
 | Helen Mirren als Deep Thought (voice) |
 | Thomas Lennon als Eddie the Computer (voice) |
 | Stephen Fry als Narrator / The Guide (voice) |
 | Warwick Davis als Marvin |
 | Bill Bailey als The Whale (voice) |
 | Su Elliot als Pub Customer |
| Dominique Jackson als Fook |
 | Simon Jones als Ghostly Image |
 | Kelly Macdonald als Reporter |
 | Ian McNeice als Kwaltz (voice) |
 | Steve Pemberton als Mr. Prosser |
 | Albie Woodington als Barman |
| Mark Longhurst als Bulldozer Driver |
| Jack Stanley als Lunkwill |
| Mak Wilson als Vogon Interpreter (voice) |
 | Mark Gatiss als Additional Vogon Voices |
 | Reece Shearsmith als Additional Vogon Voices |
| Mason Ball als Creature Performer |
| Sarah Bennett als Creature Performer |
| Danny Blackner als Creature Performer |
 | Hayley Burroughs als Creature Performer |
 | Cecily Fay als Creature Performer |
| Aron Freeman als Creature Performer |
 | Ian Kay als Creature Performer |
| Nikki Bond als Creature Performer |
| Mohsen Nouri als Creature Performer |
| Oliver Parham als Creature Performer |
| Nigel Plaskitt als Creature Performer |
| Lynn Robertson Bruce als Creature Performer |
 | Jerome St. John Blake als Vogon Soldier |
| Milo Bodrozic als Vogon Soldier |
| Martin Dawson als Vogon Soldier |
| Dan Ellis als Vogon Soldier |
| Steve Grindle als Vogon Soldier |
| Art Hewitt als Vogon Soldier |
 | Simon Hibbs als Vogon Soldier |
| Rob Horseman als Vogon Soldier |
| Mike Lewis als Vogon Soldier |
| Paul Nathaniel als Vogon Soldier |
| Tim Perrin als Vogon Soldier |
| Jessie Riley als Vogon Soldier |
| Tucker Stevens als Vogon Soldier |
| Ashley Stuart als Vogon Soldier |
 | Benjamin Uttley als Vogon Soldier |
| Patrick Walker als Vogon Soldier |
 | Spencer Wilding als Vogon Soldier |
| William Wollen als Vogon Soldier |
 | Edgar Wright als Deep Thought Technician (uncredited) |
 | Jason Schwartzman als Gag Halfrunt (uncredited) |
 | Mark Rhino Smith als Pall Bearer (uncredited) |
| Igor Jadue-Lillo | Director of Photography |
| Garth Jennings | Director |
| Douglas Adams | Novel |
| Douglas Adams | Screenplay |
| Karey Kirkpatrick | Screenplay |
| Niven Howie | Editor |
| Mike Valentine | Underwater Camera |
| Charlotte-Rose Armstrong | Assistant Costume Designer |
| Bruce Gallup | Painter |
| Gary Barber | Producer |
| Nick Goldsmith | Producer |
| Jay Roach | Producer |
| Robbie Stamp | Executive Producer |
| Jonathan Glickman | Producer |
| Douglas Adams | Executive Producer |
| Derek Evans | Executive Producer |
| Roger Birnbaum | Producer |
| Marcia Ross | Casting |
| Joby Talbot | Original Music Composer |
| Rebekah Rudd | Co-Producer |
| Caroline Hewitt | Co-Producer |
| Todd Arnow | Co-Producer |
| Frank Walsh | Supervising Art Director |
| Joel Collins | Production Design |
| Tim Jetis | Art Department Coordinator |
| Liz Tagg | Hair Designer |
| Duncan Jarman | Prosthetic Makeup Artist |
| Warwick Campbell | Sequence Supervisor |
| Demetri Jagger | Video Assist Operator |
| Richard Whelan | First Assistant Director |
| Daniel Pettipher | Production Manager |
| Liz Tagg | Makeup Designer |
| Joey Coughlin | Electrician |
| Alan Cassie | Art Direction |
| Richard Darwin | Animatronics Designer |
| Andy Shelley | Dialogue Editor |
| Bjorn Ole Schroeder | ADR Supervisor |
| Alastair Sirkett | Sound Effects Editor |
| Ben Flatter | Visual Effects Coordinator |
| Colin Childs | Propmaker |
| Wilma Dunn | Special Effects Coordinator |
| Jason Rayford | Stand In |
| Deborah Simmrin | Unit Publicist |
| PJ Harling | Visual Effects Editor |
| Robin Green | Boom Operator |
| Andy Thomson | Art Direction |
| Abby Callahan | Post Production Supervisor |
| Verner Gresty | Technical Supervisor |
| Philip Clark | Location Scout |
| Rosemary Burrows | Costume Supervisor |
| Warren Lever | Carpenter |
| Jonathan Neill | CG Supervisor |
| David Broder | Location Manager |
| Alastair Sirkett | Sound Designer |
| Oliver Jarlett | Mechanical Designer |
| Tim Lanning | Greensman |
| Paul Edwards | Steadicam Operator |
| Christian Kennedy | Set Dressing Artist |
| Jim Dowdall | Stunt Coordinator |
| Nadia Aleyd | Casting Associate |
| Dimitri Bakalov | 3D Animator |
| Angus Bickerton | Visual Effects Supervisor |
| Kate Beckly | Set Decoration |
| Phil Sims | Art Direction |
| Rebecca Amissah | Art Department Assistant |
| Simon Finney | Camera Operator |
| Laurie Sparham | Still Photographer |
| John Arnold | Key Grip |
| Jan Meade | Projection |
| Simon Jones | Transportation Coordinator |
| Kate Griffin | Production Accountant |
| Mark Holding | Sound Mixer |
| John Gamble | First Assistant Camera |
| Bruce Bigg | Property Master |
| Deryn Stafford | Production Coordinator |
| Ian Wilson | Supervising Sound Editor |
| Bobby Prince | Unit Manager |
| Dean Clegg | Assistant Art Director |
| Nikita Rae | Hairstylist |
| Tim Earl | Driver |
| Mark Wyllie | Mixing Engineer |
| Gary Gillingham | Production Controller |
| Andy Bennett | Stunts |
| Ronnie Phillips | Rigging Gaffer |
| Paul Gooch | Makeup Artist |
| Stewart Monteith | Best Boy Electric |
| Eddie Knight | Gaffer |
| Robin Knapp | Assistant Sound Editor |
| Richard Baker | Digital Compositors |
| Sammy Sheldon | Costume Design |
| Peter Heslop | Unit Production Manager |
| Phil Ashton | Color Timer |
| Mark Harris | First Assistant Editor |
| John Marzano | Aerial Director of Photography |
| Rose Wilde | Set Production Assistant |
| Christopher Austin | Orchestrator |
| Alistair Bell | Visual Effects |
| Spike Jonze | Thanks |
| Ian Buckley | Grip |
| Ken Dailey | Visual Effects Producer |
| Rick Mietkowski | VFX Director of Photography |
| Lucy St Giles | Casting Assistant |
| Carrie Holecek | Digital Intermediate Producer |
| Rob Meisenholder | Accountant |
| Jon Hollis | Title Designer |
| Anita Dhillon | Graphic Designer |
| Darren Vincent | Camera Trainee |
| Fernanda Moreno | CG Artist |
| Jemma Scott-Knox-Gore | Contact Lens Technician |
| Iain Lawrence | Assistant Director |
| Oliver Faldo | VFX Artist |
| Tamana Bleasdale | Second Assistant Director |
| Tony Chance | Storyboard Artist |
| Tony Currie | ADR Editor |
| Leo Burton | Production Assistant |
| Jeffrey Chernov | Production Executive |
| Dominic Leung | Second Unit Director |
| Mark Appleby | ADR Recordist |
| Diane Greaves | Foley Artist |
| Chas Bain | Focus Puller |
| Laura Dubsky | Rotoscoping Artist |
| Jo Budden | Dresser |
| Steve Pang | Visual Effects Assistant Editor |
| Denny Edwards | Costume Assistant |
| Laurence Harvey | Special Effects Technician |
| Shaun Cobley | Assistant Camera |
| Hayley Lyon | Assistant Accountant |
| Celia Yau | Key Costumer |
| Jamie McCarter | Animation Director |
| Christopher Austin | Conductor |
| Denise Hanrahan | Production Runner |
| Michael Fleming | Dressing Prop |
| Judith Babcock | Post Production Coordinator |
| Paul Drenning | ADR Mixer |
| Tim Dean | Libra Head Technician |
| Camilla Stephenson | Assistant Location Manager |
| Billy Pegg | Location Assistant |
| Sunny Rowley | Key Set Costumer |
| Michael Connell | Supervising Music Editor |
| Chris Croucher | Crowd Assistant Director |
| David Decio | Third Assistant Director |
| Susan Luciani | Clapper Loader |
| Russell Barnett | Wardrobe Master |
| Tamsin Wright | Set Costumer |
| Claire Garrett | Art Department Trainee |
| Paul Duff | Supervising Carpenter |
| Chris Dale | Second Assistant Camera |
| Vanessa Baker | ADR Voice Casting |
| Mark Wright | Negative Cutter |
| Daniel May | Art Direction |
| Mark Hopkins | Set Runner |
