 | Paul Giamatti als Paul Hunham |
 | Dominic Sessa als Angus Tully |
 | Da'Vine Joy Randolph als Mary Lamb |
 | Carrie Preston als Miss Lydia Crane |
 | Brady Hepner als Teddy Kountze |
 | Ian Dolley als Alex Ollerman |
 | Jim Kaplan als Ye-Joon Park |
 | Michael Provost als Jason Smith |
 | Andrew Garman als Dr. Hardy Woodrup |
 | Naheem Garcia als Danny |
 | Stephen Thorne als Thomas Tully |
 | Gillian Vigman als Judy Clotfelter |
 | Tate Donovan als Stanley Clotfelter |
 | Darby Lee-Stack als Elise |
 | Bill Mootos als Mr. Endicott |
 | Dustin Tucker als Mr. Rosensweig |
 | Juanita Pearl als Mary's Sister Peggy |
 | Alexander Cook als Priest / Bartender |
 | Liz Bishop als Office Lady |
| Cole Tristan Murphy als Toothbrushing Student |
| Will Sussbauer als Cobb Salad Student |
 | Carter Shimp als Weed Buyer Harriman |
 | Michael Malvesti als Christmas Tree Guy |
 | Dakota Lustick als Christmas Tree Helper |
 | Melissa McMeekin als Hooker |
| Jonathan von Mering als ER Doctor |
 | Rena Maliszewski als ER Nurse |
| Osmani Rodriguez als Pharmacist |
 | Oscar Wahlberg als Pinball Player |
 | Dan Aid als Vietnam Vet Kenneth |
| Mike Kaz als Hip Party Guest |
 | Kelly AuCoin als Hugh Cavanaugh |
 | Colleen Clinton als Mrs. Cavanaugh |
| Fred Robbins als Santa Claus |
 | David J. Curtis als Psychiatric Orderly |
 | Pamela Jayne Morgan als Waitress |
| Davis Robinson als Maître d'hôtel |
| Joe Howell als Liquor Store Cashier |
| Peter Krasinski als Choir Leader |
| Greg Chopoorian als Jason Smith's Father |
 | Ian Lyons als Miss Crane's Boyfriend |
 | Kevin Fennessy als Irritated Movie Patron |
| Kevin Daigneault als Barton Parent (uncredited) |
| Bhanu Gopal als Boston Streeter / Pedestrian (uncredited) |
| Alexander Payne | Director |
| David Hemingson | Writer |
| Mark Johnson | Producer |
| Ryan Warren Smith | Production Design |
| Jeremy Woolsey | Art Direction |
| Wendy Chuck | Costume Design |
| Chris Stinson | Line Producer |
| Bill Block | Producer |
| David Hemingson | Producer |
| Lisa Lobel | Casting |
| Donyale McRae | Makeup Artist |
| Scott Hersh | Makeup Artist |
| Jennifer Douglas | Hair Designer |
| Sarah Rubano | Makeup Department Head |
| Michael White | Hair Department Head |
| David J. Schwartz | Sound Mixer |
| James B. Appleton | Boom Operator |
| Adam Bellao | Special Effects Supervisor |
| Tommy Carroll | Special Effects Technician |
| Nathan Carlson | Graphic Designer |
| Markus Wittman | Set Decoration |
| Lori Gomes | Hairstylist |
| Rod Smith | First Assistant Director |
| John Nasraway | Second Assistant Director |
| Anastasia Tsikhanava | Set Costumer |
| Eigil Bryld | Director of Photography |
| Lori DeLapp | Costume Supervisor |
| Biko Gogaladze | Foley Artist |
| Frank Gaeta | Sound Designer |
| Patrick Cyccone Jr. | Sound Re-Recording Mixer |
| Aaron Bouchard | Utility Sound |
| Dia Donnelly | Utility Sound |
| Preston Treadwell | Special Effects Technician |
| Harrison Wayne | Special Effects Technician |
| Elias Saliba | VFX Artist |
| Randi Glass | Casting Associate |
| Caroline Blanco | Extras Casting |
| Owen Guinessey | Extras Casting |
| Gracie Kennedy | Extras Casting |
| Frans Wetterings III | Gaffer |
| Justin Sulham | Grip |
| Michael Spurling | Grip |
| Tomek Doroz | Grip |
| Catriona Crosby | Set Dresser |
| Sean Doyle | Set Dresser |
| Alix Metros | Set Decoration Buyer |
| Setha Phongsavan | Set Dresser |
| Anthony Raymond | Set Designer |
| Ashley L. Sykes | Set Decoration Buyer |
| Brandon Warner | Set Dresser |
| Amy Greene | Stunt Coordinator |
| Kevin Tent | Editor |
| Justice Hedenberg | Stunts |
| Corey Hibbert | Stunts |
| John Vincent Mason | Stunts |
| A.J. Paratore | Stunts |
| Ben Rezendes | Stunts |
| Alan Francis Sullivan | Stunts |
| Andrew Golov | Executive Producer |
| Tom Williams | Executive Producer |
| Thom Zadra | Executive Producer |
| Mark Orton | Original Music Composer |
| Richard Ford | Executive Music Producer |
| Matt Aberle | Music Supervisor |
| Joshua Gonzales | Production Supervisor |
| Terrence Hayes | "B" Camera Operator |
| Seacia Pavao | Still Photographer |
| Scott Hersh | Key Makeup Artist |
| Jennifer Douglas | Key Hair Stylist |
| Dianna Reardon | Ager/Dyer |
| Todd England Nicodemus | Dolly Grip |
| Josh Cronin | Production Coordinator |
| Kelly Kreiser | Production Coordinator |
| Diego Gaeta | Sound Assistant |
| Cody Skully | Sound Assistant |
| Joe Gawler | Colorist |
| Brian Bautista | VFX Editor |
| Andy Chih-Jen Chang | VFX Supervisor |
| Eun-Duk Cho | Visual Effects Producer |
| Matt Akey | Visual Effects Producer |
| Rebecca Robertson | Script Supervisor |
| Pamela Winn-Barnett | Post Production Producer |
| Glenn Kaplan | Focus Puller |
| Sarah Rubano | Makeup Artist |
| Michael White | Hair Designer |
| Mindy Elliott | Associate Editor |
| Christopher Guzman | Post Production Coordinator |
| Pete Dancy | Property Master |
| Nathan Carlson | Title Designer |
| Chandra Dyani Chavez | Assistant Costume Designer |
| Richard Ford | Music Editor |
| Susan Shopmaker | Casting |
| Chris Stinson | Unit Production Manager |
