 | Nick Cannon als Paul Brodie |
 | Timothy Hutton als Crawford Haines |
 | Shea Whigham als Tony Mazzolla |
 | Chloë Sevigny als Ms. Reilly |
 | Peter Stormare als Dr. Phillips |
 | Clea DuVall als Kerry Isalano |
 | Bill Stinchcomb als Cope |
 | Meade Patton als Forsythe |
 | Michael Byrnes als Orderly |
 | Gregory Gast als Echo |
| Joan Roberts als God (voice) |
| Luke Sexton als Orderly #1 |
 | Tim J. Smith als Orderly #2 |
| Gus Krieger | Writer |
| Jonathan Liebesman | Director |
| Ann Peacock | Writer |
| Hugo Dominguez | Digital Effects Supervisor |
| Lukas Ettlin | Camera Operator |
| Brian Tyler | Music Director |
| Guymon Casady | Producer |
| Ross M. Dinerstein | Producer |
| Benjamin Forkner | Producer |
| Bobby Schwartz | Producer |
| Jean-Luc De Fanti | Executive Producer |
| Brian Tyler | Music |
| Lukas Ettlin | Director of Photography |
| Sean Carter | Editor |
| Charisse Cardenas | Production Design |
| Laine Abramson | Set Decoration |
| Caroline B. Marx | Costume Design |
| Louisa Gore Hamn | Makeup Artist |
| David Barber | Sound Re-Recording Mixer |
| Christian Dwiggins | Sound Designer |
| Mitch Pierson | Sound Editor |
| Paul Seradarian | Sound Editor |
| R.D. White | Sound Designer |
| Gus Krieger | Co-Producer |
| Jonathan Liebesman | Executive Producer |
| Alissa M. Kantrow | Line Producer |
| Laray Mayfield | Casting |
| Alissa M. Kantrow | Unit Production Manager |
| Terri Martin | First Assistant Director |
| Seth Hansen | Second Assistant Director |
| Steven Ritzi | Stunt Coordinator |
| Larry Long | Sound Mixer |
| Valeria Migliassi Collins | Script Supervisor |
| Dan Cornwall | Gaffer |
| Eric Damazio | Key Grip |
| Christopher Kulikowski | Post Production Supervisor |
| Ann Peacock | Executive Producer |
