 | Henry Cavill als Napoleon Solo |
 | Armie Hammer als Illya Kuryakin |
 | Alicia Vikander als Gaby Teller |
 | Elizabeth Debicki als Victoria Vinciguerra |
 | Luca Calvani als Alexander |
 | Sylvester Groth als Uncle Rudi |
 | Hugh Grant als Waverly |
 | Jared Harris als Sanders |
 | Christian Berkel als Udo |
 | Misha Kuznetsov als Oleg |
 | Marianna Di Martino als Desk Clerk |
 | Julian M. Deuster als Assistant |
 | Andrea Cagliesi als Fishing Captain |
| Riccardo Calvanese als Man 2 |
 | Peter Stark als Guard (Checkpoint) |
 | David Menkin als Jones |
 | Pablo Scola als Harbourmaster |
 | Harry Taurasi als Mechanic |
| Riccardo Flammini als Man 1 |
 | Francesco De Vito als Night Manager |
| Luca Della Valle als Security Guard |
 | Simona Caparrini als Countess Allegra |
 | David Beckham als Projectionist |
| Alexander Ananasso als Italian Guard |
 | Joana Metrass als Victoria's Assistant |
 | Gabriel Lo Giudice als Count Lippi |
| Ben Wright als The Unit (uncredited) |
| Guy Williams als Captain Smith |
| Guy Ritchie | Director |
| Guy Ritchie | Screenplay |
| Lionel Wigram | Screenplay |
| James Herbert | Editor |
| Jeff Kleeman | Story |
| David C. Wilson | Story |
| John Mathieson | Director of Photography |
| Daniel Pemberton | Original Music Composer |
| Guy Ritchie | Story |
| Lionel Wigram | Story |
| Reg Poerscout-Edgerton | Casting |
| Oliver Scholl | Production Design |
| Steve Clark-Hall | Producer |
| John Davis | Producer |
| Guy Ritchie | Producer |
| Lionel Wigram | Producer |
| Max Keene | Co-Producer |
| Mark Mostyn | Co-Producer |
| Enzo Sisti | Line Producer |
| Peter Eskelsen | Associate Producer |
| David Dobkin | Executive Producer |
| Jeff Kleeman | Executive Producer |
| Steven Mnuchin | Executive Producer |
| David Allday | Art Direction |
| Guy Bradley | Art Direction |
| Toby Britton | Art Direction |
| Kate Grimble | Art Direction |
| Riccardo Monti | Art Direction |
| Remo Tozzi | Art Direction |
| Elli Griff | Set Decoration |
| Sarah Griggs | Art Department Coordinator |
| Anna Bregman | Assistant Art Director |
| Alessandro Santucci | Assistant Art Director |
| Amanda Pettett | Construction Coordinator |
| Danilo Bollettini | Special Effects Coordinator |
| Emma Callinan | Casting Associate |
| Lillie Jeffrey | Casting Associate |
| Jane Gooday | Assistant Costume Designer |
| Vivienne Jones | Assistant Costume Designer |
| Charlotte Finlay | Costume Supervisor |
| Marco Alzari | Costume Supervisor |
| Costanza Bastanti | Set Costumer |
| Gaia Cozzi | Set Costumer |
| Simon Changer | Music Editor |
| Ian Neil | Music Supervisor |
| Dave Evans | Armorer |
| Jason Horwood | Armorer |
| Sharon Mansfield | Script Supervisor |
| Jon Baker | Armorer |
| Sarah Monzani | Hair Designer |
| Francesco Alberico | Hairstylist |
| Jacqueline Bhavnani | Hairstylist |
| Zoe Clare Brown | Makeup Artist |
| Rose Crocker | Makeup Artist |
| Camilla Kirk-Reynolds | Makeup Artist |
| Sarah Monzani | Makeup Designer |
| Alex Rouse | Wigmaker |
| Dan Morgan | Dialogue Editor |
| Dan Morgan | ADR & Dubbing |
| Peter Gleaves | ADR & Dubbing |
| Travis MacKay | ADR & Dubbing |
| James Shannon | Dolby Consultant |
| Peter Burgis | Foley |
| Andrea King | Foley |
| James Boyle | Sound Designer |
| Ben Meechan | Sound Effects Editor |
| Chris Burdon | Sound Re-Recording Mixer |
| Gilbert Lake | Sound Re-Recording Mixer |
| Dominic Gibbs | Supervising Sound Editor |
| Alessio Bramucci | Gaffer |
| Chuck Finch | Gaffer |
| John Gamble | Camera Operator |
| Dave Hamilton-Green | Camera Operator |
| Tony Jackson | Camera Operator |
| Gianmaria Majorana | Camera Operator |
| Chris Plevin | Camera Operator |
| Marco Sacerdoti | Camera Operator |
| Gary Spratling | Camera Operator |
| Adam Dale | Helicopter Camera |
| Eric Biglietto | Helicopter Camera |
| Paul Edwards | Steadicam Operator |
| Mike Valentine | Underwater Camera |
| Daniel Smith | Still Photographer |
| Kim Honeyman | Digital Intermediate |
| Philip Hedgecock | First Assistant Editor |
| Guido Leonarduzzi | Rigging Grip |
| Victoria Albanese | Visual Effects Coordinator |
| Melanie Murray | Visual Effects Coordinator |
| Steve Pang | Visual Effects Editor |
| Marlies Schacherl | Visual Effects Coordinator |
| Sven Pannicke | Visual Effects Producer |
| Kerstin Kensy | Visual Effects Producer |
| Louise Hutchinson | Visual Effects Producer |
| Chloe Grysole | Visual Effects Producer |
| Angela Barson | Visual Effects Supervisor |
| Stuart Bullen | Visual Effects Supervisor |
| Florian Gellinger | Visual Effects Supervisor |
| Oliver Schulz | CG Supervisor |
| Callum Davison | Greensman |
| Roberta Federico | Set Designer |
| Elizabeth West | Script Supervisor |
| James Hambidge | Supervising Art Director |
| Christopher Learmonth | VFX Editor |
| Mauro Aversano | Stunts |
| Adam Horley | Dialogue Editor |
| Paul Purdy | Property Master |
| Joanna Johnston | Costume Design |
| Jo McLaren | Stunts |
| Sarah Lochlan | Stunts |
