 | Keanu Reeves als Neo / Thomas Anderson |
 | Carrie-Anne Moss als Trinity / Tiffany |
 | Yahya Abdul-Mateen II als Morpheus / Agent Smith |
 | Jonathan Groff als Smith |
 | Jessica Henwick als Bugs |
 | Neil Patrick Harris als The Analyst |
 | Jada Pinkett Smith als General Niobe |
 | Priyanka Chopra Jonas als Sati |
 | Christina Ricci als Gwyn de Vere |
 | Lambert Wilson als The Merovingian |
 | Andrew Lewis Caldwell als Jude |
 | Toby Onwumere als Sequoia |
 | Max Riemelt als Sheperd |
 | Joshua Grothe als FunktIøn |
 | Brian J. Smith als Berg |
 | Eréndira Ibarra als Lexy |
 | Michael X. Sommers als Skroce |
 | L. Trey Wilson als Hanno |
 | Mumbi Maina als Ellster |
 | Max Mauff als Quillion |
 | Purab Kohli als Zen |
 | Freema Agyeman als Astra |
 | Sabrina Strehl als Fiona |
 | Andrew Rothney als Scott |
 | Cooper Rivers als GJ |
 | Esther Silex als Brainstormer #1 |
 | Frank Isom als Brainstormer #2 |
 | Leo Sheng als Bobbi |
 | Telma Hopkins als Freya |
 | John Gaeta als Deus Machina Employee #1 |
 | Donald Mustard als Deus Machina Employee #2 |
 | Kim Libreri als Deux Machina Employee #3 |
 | Joe Mazza als Cop |
 | Chad Stahelski als Chad |
 | Julian Grey als Brandon |
 | Gaige Chaturantabut als Donnie |
 | Tiger Hu Chen als M.O.T.C. |
 | Volkhart Buff als Kush |
 | Amadei Weiland als Agent White |
 | Stephen Dunlevy als Agent Jones |
 | Ellen Hollman als Echo |
 | Ian Pirie als Lieutenant |
 | Nicolas de Pruyssenaere als Lead SWAT |
 | Felix Quinton als SWAT |
 | Aaron Pina als FBI |
 | Dani Swan als Woman in Red |
 | London Breed als Calliope |
 | Steven Roy als Thomas's Reflection |
 | Mercy Malick als Wife |
 | Juval Dieziger als Utrix Driver |
 | James McTeigue als Innocuous Man |
 | Sarah McTeigue als Tiffany's Reflection |
 | William W. Barbour als Businessman (uncredited) |
 | Kenny Beers als SWAT Team Member / Runner (uncredited) |
 | Thomas Dalby als SWAT Officer (uncredited) |
 | James D. Weston II als Military / SWAT (uncredited) |
| Lana Wachowski | Director |
| Steve Skroce | Storyboard Artist |
| Grant Hill | Producer |
| Lilly Wachowski | Characters |
| Geof Darrow | Conceptual Design |
| Lana Wachowski | Producer |
| Dan Glass | Visual Effects Supervisor |
| Lindsay Pugh | Costume Design |
| Marc-André Gerke | Location Coordinator |
| John Toll | Director of Photography |
| Joseph Jett Sally | Editor |
| Dane A. Davis | Sound Designer |
| Dane A. Davis | Supervising Sound Editor |
| Albert Gasser | Sound Effects Editor |
| Scott Kinzey | Boom Operator |
| Barry O'Sullivan | Sound Mixer |
| Thomas Wallis | Boom Operator |
| Aharon Bourland | Visual Effects Supervisor |
| Ankur Mishra | Visual Effects |
| Lana Wachowski | Characters |
| James McTeigue | Producer |
| Garrett Grant | Executive Producer |
| Terry Needham | Executive Producer |
| Michael Salven | Executive Producer |
| Jesse Ehrman | Executive Producer |
| Bruce Berman | Executive Producer |
| Daniele Massaccesi | Director of Photography |
| Hugh Bateup | Production Design |
| Peter Walpole | Production Design |
| Johnny Klimek | Original Music Composer |
| Tom Tykwer | Original Music Composer |
| Marta Camer | Makeup Artist |
| Stephan Dupuis | Makeup Artist |
| Stephen M. Kelley | Makeup Artist |
| Aisha King | Makeup Artist |
| Jalil Romo Corro | Makeup Artist |
| Jamie Hearing | VFX Artist |
| Alexander T.H. Browne | VFX Artist |
| Daniel Parker | Makeup Designer |
| Heike Merker | Makeup Designer |
| Richard Bloom | Art Direction |
| Ravi Bansal | Art Direction |
| Stephan O. Gessler | Supervising Art Director |
| Wolfgang Metschan | Art Direction |
| Tarnia Nicol | Art Direction |
| Nanci Noblett | Art Direction |
| Esther Schreiner | Art Direction |
| Maya Shimoguchi | Supervising Art Director |
| Lisa Brennan | Set Decoration |
| Barbara Munch | Set Decoration |
| Chris Cortner | Set Designer |
| Wilko Drews | Set Designer |
| Jens Gaube | Set Dresser |
| Claudia Granucci | Set Designer |
| Celina Hollaender | Set Designer |
| Christian Hoobyar | Set Dresser |
| Loren Hoselton | Set Dresser |
| Ines Kramer | Set Designer |
| Robin Plöger | Set Dresser |
| Serban Rotariu | Set Designer |
| Michael Thede | Set Dresser |
| Mariana Vasconcellos | Set Designer |
| Louis Visco | Set Dresser |
| Paul Wingert | Set Dresser |
| Stefanie Übelhör | Set Designer |
| Bryan O. Watkins | Sound Effects Editor |
| Lars Ginzel | Sound Re-Recording Mixer |
| Matthew W. Kielkopf | Sound Editor |
| Matthew W. Kielkopf | First Assistant Sound Editor |
| Matthias Lempert | Sound Re-Recording Mixer |
| Markus Stemler | Sound Effects Editor |
| Pierre Buffin | Visual Effects Supervisor |
| Tyson Donnelly | Visual Effects Supervisor |
| Moriah Etherington-Sparks | Visual Effects Producer |
| Daniel Hazeltine | VFX Artist |
| Marco Lee | VFX Artist |
| Owen McGonigle | VFX Artist |
| Javier Meroño | Visual Effects |
| Pete Polyakov | Visual Effects Supervisor |
| Kazia Roach | VFX Artist |
| Balthazar Sahel | VFX Artist |
| Annabelle Zoellin | Visual Effects Producer |
| Javier Arrieta | Costume Supervisor |
| Caroline Hill | Costume Supervisor |
| Gabriel Rios | Stunts |
| Tim Rigby | Stunts |
| Cort Rogers | Stunts |
| Scott Rogers | Stunt Coordinator |
| Zachary Rogers | Utility Stunts |
| Hannah Spreitzenbarth | Stunts |
| Cale Schultz | Stunts |
| Ming Qui | Stunts |
| Jeff Mosley | Stunts |
| Mike Möller | Stunts |
| Brett Praed | Utility Stunts |
| Chris Reid | Stunts |
| Mustafa Beyter | Stunts |
| Eric Brown | Fight Choreographer |
| Doug Coleman | Stunts |
| Zack Duhame | Stunts |
| Jonathan Eusebio | Stunt Coordinator |
| Felix Audu | Stunts |
| Dave Ardito | Stunts |
| Joel Adrian | Stunts |
| Raffael Armbruster | Stunt Double |
| Can Aydin | Stunt Double |
| Billy Buff | Stunt Double |
| Daniele Massaccesi | Steadicam Operator |
| Gabriel Isaac Mounsey | Music Editor |
| Gabriel Isaac Mounsey | Score Engineer |
| Hans Hafner | Music Editor |
| Gene Pritsker | Orchestrator |
| Justin Bell | Orchestrator |
| Lana Wachowski | Writer |
| David Mitchell | Writer |
| Aleksandar Hemon | Writer |
| Karin Wachowski | Executive Producer |
| Carmen Cuba | Casting |
| Garrett Grant | Unit Production Manager |
| Toby Pease | Unit Production Manager |
| Miki Emmrich | Unit Production Manager |
| Michael Salven | First Assistant Director |
| Michael Saunders | Second Assistant Director |
| Kim Whittaker | Second Assistant Director |
| Aimee Allegretti | Executive Producer |
| Henning Molfenter | Co-Producer |
| Charlie Woebcken | Co-Producer |
| Christoph Fisser | Co-Producer |
| Miki Emmrich | Co-Producer |
| Matt Bilski | Associate Producer |
| Loranne Turgeon | Associate Producer |
| Megan Gray | Assistant Costume Designer |
| Flora Moody | Makeup Designer |
| Flora Moody | Hair Designer |
| Reetu Aggarwal | 3D Artist |
| Debbie Evans | Stunts |
| Robin Lynn Bonaccorsi | Stunts |
| Phong Giang | Stunts |
| Mark De Alessandro | Stunt Double |
| Eliza Coleman | Stunts |
| Lance Gilbert | Stunts |
| Renae Moneymaker | Stunt Double |
| Oakley Lehman | Stunts |
| Danny Wynands | Stunts |
| Darrin Prescott | Stunts |
| Lane Leavitt | Stunts |
| Tim Trella | Stunts |
| Tom Elliott | Stunts |
| Mickey Giacomazzi | Stunt Driver |
| Jolene Van Vugt | Stunt Double |
| George Hull | Conceptual Design |
