 | George Clooney als Augustine Lofthouse |
 | Felicity Jones als Sully |
 | David Oyelowo als Adewole |
 | Caoilinn Springall als Iris |
 | Kyle Chandler als Mitchell |
 | Demián Bichir als Sanchez |
 | Tiffany Boone als Maya |
 | Sophie Rundle als Jean |
 | Ethan Peck als Young Augustine |
 | Tim Russ als Mason Mosley |
 | Miriam Shor als Mitchell's Wife |
 | Lilja Nótt Þórarinsdóttir als Frantic Woman - Katherine |
 | Hanna María Karlsdóttir als Older Woman |
 | Atli Óskar Fjalarsson als Soldier |
 | Edan Hayhurst als Mitchell Son 1 |
 | Jamie Schneider als Mitchell Son 2 |
| Eysis Clacken als Rachel |
 | Sam Bond als Father in Plane |
 | Tia Bannon als Jasmine |
 | Natasha Jenssen als Speech Guest (uncredited) |
 | Bharat Mistri als Speech Guest (uncredited) |
 | Jill Buchanan als Benefactor (uncredited) |
 | Kishore Bhatt als Speech Guest (uncredited) |
 | Gsus Lopez als Extra (uncredited) |
 | Paul Riddell als Philanthropist (uncredited) |
 | Grant Crookes als Scientific Beneficiary (uncredited) |
| George Clooney | Director |
| George Clooney | Producer |
| Stephen Mirrione | Editor |
| Alexandre Desplat | Original Music Composer |
| James D. Bissell | Production Design |
| Barbara A. Hall | Executive Producer |
| Helen Jarvis | Supervising Art Director |
| Grant Heslov | Producer |
| Martin Ruhe | Director of Photography |
| Keith Redmon | Producer |
| Mark L. Smith | Screenplay |
| John Bush | Set Decoration |
| Rachel Tenner | Casting |
| Jenny Eagan | Costume Design |
| Lee Grumett | First Assistant Director |
| Greg Baxter | Executive Producer |
| Sam Breckman | Unit Production Manager |
| Claire Fleming | Art Direction |
| Bard Dorros | Producer |
| Leifur B. Dagfinnsson | Line Producer |
| Lucy Rands | Casting |
| Nic Pallace | Art Direction |
| Tim Browning | Art Direction |
| Jonathan Opgenhaffen | Art Direction |
| Maudie Andrews | Set Decoration |
| Lily Brooks-Dalton | Book |
| Todd Shuster | Executive Producer |
| James J. Reid | Second Assistant Director |
| Cliff Roberts | Producer |
| Magnus Thulin | Line Producer |
