 | Anthony Hopkins als Dr. John Harvey Kellogg |
 | Bridget Fonda als Eleanor Lightbody |
 | Matthew Broderick als William Lightbody |
 | John Cusack als Charles Ossining |
 | Dana Carvey als George Kellogg |
 | Michael Lerner als Goodloe Bender |
 | Colm Meaney als Dr. Lionel Badger |
 | John Neville als Endymion Hart-Jones |
 | Lara Flynn Boyle als Ida Muntz |
 | Traci Lind als Nurse Irene Graves |
 | Camryn Manheim als Virginia Cranehill |
 | Roy Brocksmith als Poultney Dab |
 | Norbert Weisser als Dr. Spitzvogel |
 | Monica Parker als Mrs. Tindermarsh |
 | Jacob Reynolds als Young George Kellogg |
 | Michael Goodwin als Dr. Frank Linniman |
 | Marshall Efron als Bartholomew Bookbinder |
 | Aleksandr Slanksnis als Mr. Unpronounceable |
 | Carole Shelley als Mrs. Hookstratten |
 | Gabriel Barre als Desk Clerk |
| Robert Tracey als Ernest O'Reilly |
| Ann Tucker als Hannah |
| Jemila Ericson als Mrs. Kellogg |
 | Marianne Muellerleile als Nurse Bloethal |
| Jean Wenderlich als Ralph |
 | Mark Jeffrey Miller als Woodbine |
| Joanne Pankow als Laughing Lady |
| Mary Jane Corry als Pianist |
| Rich Valliere als Reporter #1 |
| George Nannarello als Reporter #2 |
 | James Bigwood als Reporter #3 |
| David Kraus als Laughing Instructor |
| D. Anthony Pender als Waiter on Train |
| Mary Lucy Bivins als Woman on Train |
| William Hempel als Bellman |
| Richard H. Thornton als Mr. Abernathy |
| Lisa Altomare als Mrs. Portois |
| Jim Bath als Bartender |
| Madeline Shaw als Waitress #1 |
| Barbara Phillips als Waitress #2 |
| Lindsay Hutchinson Berte als Breathing Instructor |
| Denise S. Bass als Nurse |
| Charlotte H. Ballinger als San Guest |
 | John Henry Scott als Bath Attendant |
 | Richard K. Olsen als Fox Fur Man |
| Ann Deagon als Fox Fur Woman |
| Thomas Myers Jr. als Process Server |
| Beth Bostic als Miss Jarvis |
| Kerry Maher als Doorman |
| Sam Garner als Farrington |
| T. Coraghessan Boyle | Novel |
| Gerry Hambling | Editor |
| Alan Parker | Director |
| Peter Biziou | Director of Photography |
| Rachel Portman | Original Music Composer |
| Armyan Bernstein | Producer |
| Alan Parker | Producer |
| Tom Rosenberg | Executive Producer |
| Marc Abraham | Executive Producer |
| Alan Parker | Screenplay |
| Robert F. Colesberry | Producer |
| Howard Feuer | Casting |
| Juliet Taylor | Casting |
| Brian Morris | Production Design |
| Claudette Didul | Set Decoration |
| Lisa Moran | Associate Producer |
| Penny Rose | Costume Design |
| John Willett | Art Direction |
| Peter Frampton | Makeup Supervisor |
| Jerry G. Henery | Construction Foreman |
| Alan E. Lorimer | Special Effects Coordinator |
| Dennis W. Milliken | Transportation Coordinator |
| Mark Fabert | Construction Foreman |
| E.W. Bradford | Construction Coordinator |
| Frank Ferrara | Stunts |
| Gary Combs | Stunt Coordinator |
| Chris Coles | Unit Production Manager |
| James Bigwood | Unit Production Manager |
| John Copeman | Stunts |
| John Stoneham Sr. | Stunts |
| Peter Bloor | Gaffer |
| Denise Fholer | Stunts |
| Greg Brickman | Stunts |
| Joe Dunne | Stunts |
| Dean Mumford | Stunts |
| Molly M. Mayeux | Second Assistant Director |
| John Robotham | Stunt Coordinator |
| Diane Dalmonte | Stunts |
| Don Hewitt Sr. | Stunts |
| Peter Kohn | First Assistant Director |
| Gary Price | Stunts |
| John Stoneham Jr. | Stunts |
| Jennifer Lamb | Stunts |
| Robert Jauregui | Stunts |
| Nick Stamper | Stunts |
| Mark Duncan | Camera Loader |
| Carolyne Chauncey | First Assistant Editor |
| Karin Wiesel | Assistant Set Decoration |
| Judith Bouley | Local Casting |
| John Marston | Assistant Editor |
| Alan Robert Murray | Supervising Sound Editor |
| Mike Roberts | Camera Operator |
| Dianne Dreyer | Script Supervisor |
| Merrick Morton | Still Photographer |
| Marina Marit | Costumer |
| Alonzo Wilson | Costumer |
| Kirsten Hecktermann | Assistant Costume Designer |
| Mike Moad | Dolly Grip |
| David Feldman | Assistant Editor |
| Terry Rodman | Supervising Sound Editor |
| Nelson Stoll | Sound Mixer |
| John Hay | Wardrobe Supervisor |
| Bill Coe | First Assistant Camera |
| Paddy Kiely | Second Assistant Camera |
| Mary Montiforte | Production Controller |
| Anna Behlmer | Sound Re-Recording Mixer |
| Stephanie Wertlake | Art Department Coordinator |
| Ingrid Johanson | Production Coordinator |
| Martin Samuel | Hairstylist |
| Scott Kinzey | Boom Operator |
| Andy Nelson | Sound Re-Recording Mixer |
| Scott D. Jackson | Foley Supervisor |
| David Wolowic | First Assistant Sound Editor |
| David Eckert | Assistant Art Director |
| Paul Cheponis | Assistant Set Decoration |
| Alenka Pavlin | Cableman |
| Angela Billows | Assistant Costume Designer |
| Scott Millan | Sound Re-Recording Mixer |
| Polar Bear Shaw | Leadman |
| Walter Newman | Sound Editor |
| Jayme S. Parker | Sound Editor |
| Barbara Harris | ADR Voice Casting |
| Ann Hadsell | ADR Recordist |
| Kevin Bartnof | Foley Artist |
| David A. Arnold | Dialogue Editor |
| Dennis J. Lootens | Rigging Gaffer |
| Dean Drabin | ADR Mixer |
| Ron Grafton | Foley Recordist |
| Marilyn Graf | Foley Mixer |
| Denise Horta | ADR Editor |
| Mike Milliken | Color Timer |
| Stephanie Flack | Dialogue Editor |
| Tyler C. Daum | Driver |
| Donald J. Malouf | Sound Editor |
| Carolyn Tapp | Foley Recordist |
| Ellen Heuer | Foley Artist |
| Juno J. Ellis | Supervising ADR Editor |
| Albert Gasser | Sound Editor |
| Lucy Coldsnow-Smith | Dialogue Editor |
| Rachel Aberly | Unit Publicist |
| Constance A. Kazmer | Dialogue Editor |
| Mary Jo Lang | Foley Mixer |
| Bob Hart | Negative Cutter |
| Hilda Hodges | Foley Artist |
| John Roesch | Foley Artist |
| Trey Batchelor | Second Second Assistant Director |
