 | Woody Harrelson als Dr. Michael Reynolds |
 | Talisa Soto als Navajo Woman |
 | Anne Bancroft als Dr. Renata Baumbauer |
 | Jon Seda als Brandon 'Blue' Monroe |
 | Alexandra Tydings als Victoria Reynolds |
 | Andrea Roth als Head Nurse |
 | Matt Mulhern als Dr. Chip Byrnes |
 | Richard Bauer als Dr. Bradford |
| Victor Aaron als Webster Skyhorse |
 | Lawrence Pressman als Agent in Charge Collier |
 | Michael O'Neill als Agent Moreland |
 | Harry Carey, Jr. als Cashier |
 | Carmen Dell'Orefice als Arabella |
 | Bob Minor als Deputy Lynch |
 | Sal Landi als Deputy #2 |
| Harper Roisman als Mr. Vogel |
 | Kelly Perine als Fellow in Oncology |
 | Andy Berman als Fellow in Oncology |
 | John Christian Graas als Young Michael Reynolds |
 | Christopher Masterson als Jimmy Reynolds |
 | Antwon Tanner als Smokes |
 | Brett Harrelson als Younger Highway Patrol Officer |
 | Robert Downey Sr. als Telephone Voices |
 | Brooke Ashley als Calantha Reynolds |
| Robert 'Bobby Z' Zajonc als FBI Helicopter Pilot |
 | Mickey Jones als Fuzzy, Biker #1 |
 | Kirsten Getchell als Sally Byrnes |
| Emil Alexander als Walter |
| Pam Morton als Self |
| Linda M. Duenas als Hot Mexican Waitress |
 | Tony Epper als Hay Hauler |
 | Gregory Scott Cummins als Biker #2 |
| Douglas B. Hall als State Trooper |
| Dan B. Pastre als State Trooper |
 | Elaine Kagan als Woman at Gas Station |
| Jeri Arredondo als Hospital Pharmacist |
| Brian Bossetta als Hospital Security Guard |
| Cynthia Allison als CNN Reporter |
| Carolyn Tomlin als Hospital Spokesperson |
| Brian K. Francis als Navajo Boy |
| Alan Keller als Older Highway Patrol Officer |
 | Zoe Trilling als Mini-Mart Cashier |
| Betty Carvalho als Rosa |
| Matthew Abe als Surgeon |
| Eugene Boggs als Surgeon |
| Philip Zachary als Disc Jockey |
| David Green als First Inmate |
| Askia Won-Ling Jacob als UCLA Student |
| Charles Leavitt | Writer |
| Michael Cimino | Director |
| Wendy M. Craig | Set Costumer |
| Joe D'Augustine | Editor |
| Susan A. Cabral | Makeup Department Head |
| Laini Thompson | Makeup Artist |
| Lee Maymen | Art Direction |
| Jackie Carr | Set Decoration |
| Judy Goldstein | Producer |
| Edward L. Rubin | Art Direction |
| Joseph M. Caracciolo | Executive Producer |
| Michael Cimino | Producer |
| Victoria Paul | Production Design |
| Larry Spiegel | Producer |
| Michael G. Nathanson | Executive Producer |
| Douglas Milsome | Director of Photography |
| Joseph S. Vecchio | Producer |
| Christine Peters | Costume Design |
| Melissa Yonkey | Hairstylist |
| Arnon Milchan | Producer |
| Terry Liebling | Casting |
| Joseph M. Caracciolo | Unit Production Manager |
| Brian W. Cook | First Assistant Director |
| Carl Goldstein | Second Unit First Assistant Director |
| Michael Neumann | Second Assistant Director |
| Jon C. Scheide | Second Second Assistant Director |
| David Ticotin | Assistant Director |
| Matthew T. Weiner | Second Second Assistant Director |
| Eric J. Bates | Property Master |
| Janine Cavoto | Set Dresser |
| Anthony Gaudio | Painter |
| Jennifer Howard | Art Department Coordinator |
| Scott W. Leslie | Set Dresser |
| John Naehrlich | Set Dresser |
| James T. Woods | Scenic Artist |
| James Ashwill | Foley Mixer |
| Douglas Axtell | Sound Mixer |
| Brian Best | Sound Designer |
| John T. Cucci | Foley Artist |
| Joe Dorn | ADR Supervisor |
| Mildred Iatrou | Dialogue Editor |
| Adam Jenkins | Sound Re-Recording Mixer |
| Randall L. Johnson | Boom Operator |
| Linda Lew | Foley Recordist |
| Patricio A. Libenson | Sound Effects Editor |
| Michael Magill | Dialogue Editor |
| Dan O'Connell | Foley Artist |
| Roger Stevenson | Boom Operator |
| David Williams | Sound Editor |
| Richard E. Yawn | Sound Editor |
| Chet Leonard | Utility Sound |
| Al Marangoni | Special Effects |
| Dave Gregory | Visual Effects Supervisor |
| Mike Wassel | Matte Painter |
| Tobi Allyn | Stunts |
| John Borland | Stunts |
| Bobby Burns | Stunts |
| William H. Burton Jr. | Stunt Coordinator |
| Heather Burton | Stunts |
| Richard M. Ellis | Stunts |
| Richard Epper | Stunts |
| Randy Hall | Stunts |
| John Hateley | Stunts |
| Marcia Holley | Stunts |
| Buddy Joe Hooker | Stunts |
| Chris Howell | Stunts |
| Paul M. Lane | Stunts |
| Shawn Patrick Lane | Utility Stunts |
| Alvin William 'Dutch' Lunak | Stunts |
| Gary McLarty | Stunts |
| Hal Needham | Stunts |
| Manny Perry | Stunts |
| Jimmy N. Roberts | Stunts |
| Thomas Rosales Jr. | Stunts |
| George A. Sack Jr. | Stunts |
| Tim Trella | Stunt Double |
| Gary Dionne | Stunt Driver |
| Wayne Baker | Aerial Camera |
| David L. Butler | Aerial Director of Photography |
| Robert Cheung | Lighting Technician |
| Pam Connor | Grip |
| Francis Grumman | Second Unit Director of Photography |
| Daniel R. Haizlip | Best Boy Grip |
| W.C. 'Chunky' Huse | Key Grip |
| David McMillan | Rigging Gaffer |
| Steve Owen | Grip |
| Frank D. Parrish | Second Assistant Camera |
| Tony Rivetti Sr. | First Assistant "A" Camera |
| Tony Rivetti Sr. | Steadicam Operator |
| Darrell B. Sheldon | Dolly Grip |
| Lon Thompson | Gaffer |
| Don Tomich | Best Boy Electric |
| Rick Uva | Grip |
| Tony Varuola | Lighting Technician |
| Michele Juskowitz | Casting Associate |
| Katie McCaffrey | Casting Assistant |
| Matthew Messinger | Casting |
| Askia Won-Ling Jacob | Costumer |
| Alexis Scott | Assistant Costume Designer |
| Mo Henry | Negative Cutter |
| William Marrinson | Assistant Editor |
| Philip Pucci | Assistant Editor |
| Bob Putynkowski | Color Timer |
| Steve Moe | Assistant Editor |
| Patrick Mignano | Assistant Location Manager |
| Michael Neale | Location Manager |
| Donald A. Potts | Location Manager |
| Dondi Bastone | Music Consultant |
| Dina Eaton | Music Editor |
| Maurice Jarre | Conductor |
| Lily Newman | Music Consultant |
| Tom Boyd | Musician |
| Norman Ludwin | Musician |
| James Thatcher | Musician |
| Lyn Matsuda Norton | Script Supervisor |
| John Orlebeck | Transportation Coordinator |
| Pablo Ferro | Graphic Designer |
| Pablo Ferro | Title Designer |
| Matthew Klipper | Second Assistant Accountant |
| James Land | Stand In |
| Jim McCarthy | Production Accountant |
| Alan D. Purwin | Pilot |
| Marvin Watkins | Technical Advisor |
| Robert Waynick | Stand In |
| Robert 'Bobby Z' Zajonc | Pilot |
| Michael Parkhurst | Technical Advisor |
| Maurice Jarre | Music |
| Tom Elliott | Stunts |
