 | Jordana Brewster als Chrissie |
 | Taylor Handley als Dean |
 | Diora Baird als Bailey |
 | Matt Bomer als Eric |
 | R. Lee Ermey als Uncle Charlie Hewitt / Sheriff Hoyt |
 | Lew Temple als Sheriff Winston Hoyt |
 | Andrew Bryniarski als Thomas Hewitt / Leatherface |
 | Tim DeZarn als Slaughterhouse Supervisor |
 | Lee Tergesen als Holden |
 | Cyia Batten als Alex |
 | Terrence Evans als Monty Hewitt |
| Marietta Marich als Luda Mae Hewitt |
 | L.A. Calkins als Sloane |
| Allison Marich als Young Luda Mae |
| Marcus H. Nelson als Lackey |
| Kathy Lamkin als Tea Lady |
 | Melody Chase als Biker Chick (uncredited) |
| Emily Kaye als Biker Chick (uncredited) |
 | John Larroquette als Narrator (voice) (uncredited) |
| Jonathan Chibnall | Editor |
| Lukas Ettlin | Director of Photography |
| Sheldon Turner | Screenplay |
| Jonathan Liebesman | Director |
| Steve Jablonsky | Original Music Composer |
| Jim May | Editor |
| Jake Garber | Makeup Effects |
| Bradley Fuller | Producer |
| Kim Henkel | Producer |
| Michael Bay | Producer |
| Mike Fleiss | Producer |
| John Frick | Art Direction |
| Mari-An Ceo | Costume Design |
| Carla Palmer | Makeup Department Head |
| Marco Rubeo | Production Design |
| Randy Huke | Set Decoration |
| Lisa Fields | Casting |
| Kathy Kiatta | Costume Supervisor |
| Robert Kuhn | Executive Producer |
| Kevin Wasner | Makeup Effects |
| Mark Ordesky | Executive Producer |
| Grady Holder | Makeup Effects |
| Greg Nicotero | Makeup Effects |
| Alma Kuttruff | Co-Producer |
| Sheldon Turner | Story |
| Toby Emmerich | Executive Producer |
| Andrew Form | Producer |
| K.C. Hodenfield | Co-Producer |
| Tobe Hooper | Producer |
| Guy Stodel | Executive Producer |
| Jeffrey Allard | Executive Producer |
| David J. Schow | Story |
| Frank Parrish | Key Hair Stylist |
| Kelly Nelson | Hair Department Head |
| Jourdan Henderson | Art Department Coordinator |
| Tom Dreesen | Construction Coordinator |
| Gina Grande | Script Supervisor |
| Brooke Satrazemis | Script Supervisor |
| Troy Breeding | Key Makeup Artist |
| Robert Hicks | Key Rigging Grip |
| Brown Cooper | Second Unit Director of Photography |
| Michael Scott | Camera Operator |
| Matt Cowan | Dolly Grip |
| Greg Travis | Rigging Grip |
| George R. Niedson | Steadicam Operator |
| Peter Simonite | First Assistant "A" Camera |
| Theda Cunningham | First Assistant "B" Camera |
| Steve Drake | Best Boy Grip |
| Leeann Radeka | Key Costumer |
| Robert B. Reynolds | Rigging Gaffer |
| Elspeth Lauder Mickel | Seamstress |
| Stephanie A. Steel | Set Costumer |
| Jimmy Lindsey | Camera Operator |
| Douglas J. Stewart | Textile Artist |
| Edward A. Navarro | Rigging Grip |
| Leif E. Ulvog | Rigging Grip |
| Dany Navarrette | Electrician |
| Edison Jackson | Best Boy Electric |
| John Sheeren | Additional Camera |
| Kurt Grossi | Key Grip |
| Richard Nance | Rigging Grip |
| John Barba | Casting Associate |
| Russell Engels | Gaffer |
| Robyn Greer | Rigging Grip |
| Anna Abbey | Ager/Dyer |
| Sally Jackson | Casting |
| Greg Lomas | Dolly Grip |
| Van Redin | Still Photographer |
| Tom Kalbfleisch | Electrician |
| Zach Nasits | Second Assistant Camera |
| Troy Anderson | Lighting Technician |
| Donald R. Howe Jr. | Second Assistant "B" Camera |
| Nyima Johnston | Costumer |
| Marisa Ross | Casting Associate |
| Matthew King | First Assistant Camera |
| Andrea VanEpps | Stand In |
| Kurt Bryant | Stunt Coordinator |
| Henry Kingi | Stunt Driver |
| K.C. Hodenfield | Assistant Director |
| Joe Bucaro III | Stunt Driver |
| Gene Hartline | Stunts |
